Table 1 Management of corneal melting after CXL. Published cases with severe postoperative keratolysis and melting after corneal cross-linking for keratoconus

Rama et al. [12]

1

M, 32

None

OFF

Infective (Acanthamoeba)

Therapeutic PK

No

20/200

(2 months)

Labiris et al. [13]

1

M, 23

None

OFF

Inflammatory

(not known)

PK

No

ND

Angunawela et al. [14]

1

M, 40

None

OFF

Inflammatory

(not known)

Medical therapy (topical prednisolone acetate and antibiotic agent)

No

20/63

(2 months)

Rana et al. [15]

2

F, 19

M, 18

History of atopy with allergic eye disease

History of atopy with allergic eye disease

ON

OFF

Infective

(Staphylococcus aureus)

Infective (MRSA)

Temporary cyanoacrylate glue then PK

Cyanoacrylate glue

No

No

ND

ND

Mohamed-Noriega et al. [16]

1

F, 50

Diabetes

ON

Inflammatory

(nepafenac)

Tectonic PK with extracapsular cataract extraction, posterior chamber intraocular lens implantation and pupilloplasty

No

20/200

(1 months)

Zhang et al. [17]

1

F, 59

None

OFF

Inflammatory

(Potentially pathogenic variants in the ZNF469 gene)

Sutures, amniotic membrane transplantation, and fibrin sealant

No

20/40

(ND)

Schear et al. [18]

1

M, 17

Childhood asthma, Scheuermann’s disease

OFF

Unclear

Temporary cyanoacrylate glue then PK

No

20/20

(3 months)

Sasaki et al. [19]

1

M, 33

None

OFF

Inflammatory (Diclofenac)

Amniotic membrane transplantation

No

20/100

(2 months)

Tilmann et al. [20]

2

M, 34

M, 16

History of mild seasonal allergic rhinitis

None

OFF

Inflammatory

(not known)

Infective (Staphylococcus aureus)

Emergency PK

Emergency PK

No

Graft rejection

20/15

(6 months)

20/40

(3 weeks)

Gokhale et al. [21]

1

M, 19

None

OFF

Inflammatory (Diclofenac)

Temporary cyanoacrylate glue then PK

No

20/60

(1 month)

Selver et al. [22]

1

F, 20

None

OFF

Infective (septate hyaline fungal hyphae named Trametes versicolor)

Corneal suturing and medical therapy (voriconazole) and after 3 months PK

No

20/50

(5 months)