Genotype-phenotype associations in CRB1 bi-allelic patients: a novel mutation, a systematic review and meta-analysis

Table 1 Demographic characteristics of the affected individuals with bi-allelic crumbs cell polarity complex component 1 (CRB1) mutations

Demographic characteristics	Participants (N = 439)
Demographic characteristics	Mean^a	SD^b
Age at baseline (y) (n = 345)	19.1	15.2
Age of Onset (y) (n = 218)	6.4	8.2
Gender (female %)	169 (54%)
Continent(n = 318)
Asia	180 (56%)
Europe	108 (35%)
South America	19 (6%)
North America	6 (1%)
Australia	3 (1%)
Africa	2 (1%)
Country (n = 318)
China	113 (35%)
Belgium	23 (7%)
Brazil	17 (5%)
Netherlands	14 (4%)
Spain	14 (4%)
Israel/Palestine	13 (4%)
France	11 (2%)

Values are arithmetic mean ± SD for continuous variables. Categorical variables are shown as numbers (n) and percentages (%).In the country analysis, a frequency threshold of 2% was used; thus, countries with frequencies ≤ 1% were not shown. n: sample size

ISSN: 1471-2415