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Table 4 Genetic associations of crumbs cell polarity complex component 1 (CRB1) mutation types, domains, exons and genotypes with the the fundus autofluorescence characteristics

From: Genotype-phenotype associations in CRB1 bi-allelic patients: a novel mutation, a systematic review and meta-analysis

Fundus characteristics

CRB1

Mutations Types

Domain

Exons

Genotype

Peripheral Pigmentation

0.002

0.022

N. S

0.015

Peripheral retina condition

0.009

0.004

N. S

N. S

Optic Vessels

N. S

0.001

0.036

N. S

Optic Disc

0.02

N. S

0.006

N. S

Macular Pigmentation

< 0.0001

0.025

0.006

0.008

Macular Condition

0.002

< 0.0001

N. S

< 0.0001

  1. A χ2 test of independence was used to test the association between CRB1 variables and the fundus autofluorescence characteristics
  2. The associations with the refraction and OCT macular thickness were not shown since it didn’t reach the significance level
  3. N.S: not significant
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BMC Ophthalmology

ISSN: 1471-2415

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