Genotype-phenotype associations in CRB1 bi-allelic patients: a novel mutation, a systematic review and meta-analysis

Table 6 Association between different demographic, genetic and phenotypic characteristics and the best-corrected visual acuity using multiple linear regression models

Characteristics	Best Corrected Visual Acuity OU (LogMAR)
	Model 1 (R² = 0.08, P = 0.001)		Model 2 (R² = 0.92,P = 0.001)		Model 3 (R² = 0.14,P = 0.001)		Model 4 (R² = 0.15,P = 0.001)
	β	P	β	P	β	P	β	P
Age	0.272	< 0.001	0.273	< 0.001	0.332	0.001	0.254	0.003
Gender	-0.07	0.24	-0.08	0.221	-0.05	0.269	-0.12	0.152
Mutation types					0.26	0.001
Genotype			-0.108	0.09
IRDs*							0.38	< 0.001

β = standardized linear regression coefficient
BCVA: Best Corrected Visual Acuity, OU: Oculus Uterque, IRDs: inherited retinal diseases
IRDs*: used as binary variable rod-cone dystrophy and Leber congenital amaurosis

ISSN: 1471-2415