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Table 1 Summary of previous studies and current study on aniridic glaucoma patients treated with various surgical procedures

From: Outcome of illuminated microcatheter-assisted circumferential trabeculotomy following failed angle surgery in PAX6 aniridic glaucoma: a case report and literature review

Surgical procedures

Cases

Number of enrollments (eyes)

Mean age at surgery (years)

Criteria for success

Average follow-up time (years)

Success rate (%)

Complications

Prophylactic goniotomy

Chen et al. (1999) [17]

55

3.1

IOP < 22mmHg w/o medications

9.5 [range, 0.7 ~ 24]

89.1

Not observed

Therapeutic goniotomy

Walton (1986) [20]

14

7

IOP ≤ 21mmHg w/ or w/o medications

3.8 [range, 0 ~ 11]a

21.4

Not observed

Trabeculotomy

Adachi et al. (1997) [12]

12

4.7

IOP ≤ 21mmHg w/ or w/o medications and no further glaucoma surgery

11.6 [range, 4 ~ 23]

83.3

Hyphema (8.3%) and transient IOP rise (8.3%)

Trabeculectomy

Durai et al. (2021) [14]

12

17.2

5mmHg < IOP ≤ 21mmHg or reduced ≥ 20% from baseline on 2 consecutive follow-up after 3 months, w/o glaucoma reoperation, complications and loss of light perception

3.6 [range, 2 ~ 4]

41.7 (at 2-year follow-up)b

Superior ciliary staphyloma (8.3%), retinal detachment (8.3%) and cataract (41.7%)

 

Wiggins et al. (1992) [15]

15

N/Ac

IOP ≤ 21mmHg w/ or w/o medications and no complications resulting in significant visual loss

N/Ac

6.7

Retinal detachment (6.7%)

Glaucoma drainage implants

Almousa et al. (2013) [16]

8

49

5mmHg < IOP < 22mmHg w/ or w/o medications, w/o loss of light perception and no further glaucoma surgery

3.1 [range, 2.6 ~ 5.7]

87.5

Hyphema (12.5%), Persistent vitreous hemorrhage (12.5%), retinal detachment (12.5%) and phthisis bulbi (12.5%)

 

Wiggins et al. (1992) [15]

6

N/Ac

IOP ≤ 21mmHg w/ or w/o medications and no complications resulting in significant visual loss

N/Ac

83.3

Tube migration (16.7%)

Cyclodestructive procedures

Wagle et al. (1998) [18]

8

N/Ac

IOP ≤ 21mmHg w/o devastating complications or need for further glaucoma surgery

N/Ac

25

Phthisis bulbi (50%) and retinal detachment (12.5%)

 

Wallace et al. (1998) [19]

9

4.8

IOP ≤ 25mmHg w/ medications or better

11.9 [range, 4.5 ~ 17.9]

66.7

Cataract (77.8%)

 

Wiggins et al. (1992) [15]

22

N/Ac

IOP ≤ 21mmHg w/ or w/o medications and no complications resulting in significant visual loss

N/Ac

22.7

Phthisis bulbi (9.1%) and progressive cataract (4.5%)

Illuminated microcatheter-assisted circumferential trabeculotomy

This case report

1

21

IOP ≤ 25mmHg w/ or w/o medications

1

N/A

Not observed

  1. N/A Not Applicable, IOP Intraocular pressure, w/o Without, w/ With
  2. aIn the study of Walton [20], 6 eyes received alternative procedures due to the unsuccessful IOP control immediately after therapeutic goniotomy. Therefore, the minimal follow-up period was recorded as ‘0’
  3. bIn the study of Durai et al. [14], the authors mentioned that the IOP was not significantly different from the preoperative level at 3-year and 4-year follow-up, and they only counted the success rate at 2-year follow-up
  4. cIn the studies of Wagle et al. [18] and Wiggins et al. [15], the authors did not count the mean age and average follow-up time in a specific procedure or aniridic glaucoma specifically. Therefore, we marked N/A in the corresponding blank
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BMC Ophthalmology

ISSN: 1471-2415

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