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Fig. 1 | BMC Ophthalmology

Fig. 1

From: Insulin eye drops improve corneal wound healing in STZ-induced diabetic mice by regulating corneal inflammation and neuropeptide release

Fig. 1

Insulin eye drops promote corneal wound healing and corneal epithelial regeneration. (A) Schematic illustration of the experimental protocol. (B)Representative images of corneal fluorescein staining of diabetic mice in DM-In group and DM-Con group after the removal of corneal epithelium at 0 h, 12 h, 24 h, 48 h and 72 h. (C) The percentage of corneal epithelial defect area at different time points and original wound area in two groups. (n = 11 in DM-In group; n = 14 in DM-Con group). Data are expressed as mean ± SD. (D) Representative immunofluorescence images of Ki67 (red, white arrows) costaining with DAPI (blue) in diabetic cornea between two groups. Scale bars: 20 μm. STZ: streptozotocin; DM: Diabetes mellitus; DM-In, diabetic mice with topical insulin treatment; DM-Con, diabetic mice with topical physiological saline treatment; Ep, corneal epithelium; St, corneal stroma

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BMC Ophthalmology

ISSN: 1471-2415

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