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Table 1 Characteristics of Included Studies in the meta-analysis

From: Changes in corneal biomechanics in patients with glaucoma: a systematic review and meta-analysis

Author, Year

Study

Country

Ethnicity

Gender

Age(controls/patients)

Normal sample size(eye)

Experimental sample size(eye)

The type of glaucoma

Whether patients were treated for glaucoma

Machine

IOPGAT(mmHg)

Morales, 2021 [8]

Observational, cross-sectional, study

Spain

-

M/F

(21.45 ± 9.94)/(18.60 ± 11.65)

40

50

PCG

-

ORA

18.18 ± 3.94

Sullivan, 2008 [9]

Observational, cross-sectional study

The United States

Whites, Hispanics, blacks, native Americans

-

(64.5 ± 12.9)/(71.9 ± 10.0)

71

99

GLC

-

ORA

-

Hocaoglu, 2020 [10]

Observational, cross-sectional study

Turkey

-

M/F

(55.43 ± 8.65)/(62.96 ± 8.15)

133

68

POAG

Yes

ORA

16.65 ± 5.42

Fujishiro, 2020 [11]

Observational, cross-sectional study

Japan

-

M/F

(31.5 ± 5.1)/(62.9 ± 10.3)

35

104

POAG

-

Corvis ST, ORA

-

Aoki, 2021 [12]

Retrospective, cross-sectional study

Japan

-

-

(69.4 ± 13.9)/(69.1 ± 13.4)

68

68

POAG

Yes

Corvis ST, ORA

12.9 ± 3.2

Park, 2018 [13]

Retrospective, cross-sectional study

Korea

-

M/F

(56.35 ± 10.46)/NTG early: (53.92 ± 12.03)/advanced: (62.38 ± 11.96)

93

95

NTG

No

ORA

NTG early: 15.10 ± 3.18/ advanced: 15.17 ± 2.99

Cankaya, 2012 [14]

Observational, cross-sectional study

Turkey

-

M/F

(68.4 ± 5.7)/(70.2 ± 7.3)

102

78

EXG

-

ORA

16.3 ± 4.1

Yazgan, 2015 [15]

Observational, cross-sectional study

Turkey

-

M/F

(67.83 ± 6.75)/(73.50 ± 5.36)

45

30

PEXG

-

ORA

15.7 ± 4.02

Detry, 2011 [16]

Observational, cross-sectional study

Belgium

-

M/F

(58.0 ± 14.0)/(70.0 ± 11.0)

24

108

POAG

-

ORA

17.0 ± 4.3

Perucho, 2016 [17]

Observational, cross-sectional study

Spain

Caucasian

-

(18.07 ± 11.34)/(19.18 ± 11.45)

103

118

PCG

-

ORA

18.32 ± 5.13

Perucho, 2017 [18]

Observational, cross-sectional study

Spain

-

M/F

(5.20 ± 3.25)/(5.64 ± 2.85)

66

94

PCG

-

ORA

-

Gatzioufas, 2013 [19]

Prospective, observational study

German

-

M/F

(14.2 ± 3.6)/(13.6 ± 4.8)

40

40

PCG

-

ORA

 

Morita, 2012 [20]

Observational, cross-sectional study

Japan

-

M/F

(57.7 ± 12.1)/(59.1 ± 12.3)

83

83

NTG

-

ORA

14.0 ± 2.2

Costin, 2014 [21]

Prospective, observational study

Finland

-

-

(56.5 ± 5.7)/(63.6 ± 12.1)

15

13

POAG

-

ORA

14.5 ± 3.6

Beyazyıldız, 2014 [22]

Observational cross-sectional study

Turkey

-

M/F

Control: (51.2 ± 11.6)/EXG: (68.6 ± 8.5)/POAG: (58.9 ± 10.7)

50

46/66

EXG/POAG

-

ORA

EXG: (16.5 ± 4.1)/POAG: (16.4 ± 4.2)

Mangouritsas, 2009 [23]

Prospective, observational study

Greece

-

M/F

(59.2 ± 14.2)/(62.4 ± 9.8)

74

108

POAG

-

ORA

16.38 ± 2.73

Narayanaswamy, 2011 [24]

Prospective observational study

Singapore

-

M/F

Control: (54.7 ± 8.5)/PACG: (67.1 ± 9.8)/POAG: (64.6 ± 10.5)

150

131/162

PACG/POAG

-

ORA

(16.4 ± 0.8)/(14.4 ± 0.5)

Kaushik, 2012 [25]

Prospective observational study

India

-

M/F

Unclear(> 18 years of age)

71

59/36

PACG/POAG

-

ORA

PACG(16.2 ± 3.9)/POAG: (23.6 ± 12.4)

Shin, 2015 [26]

Prospective, cross-sectional study

Korea

-

M/F

(49.0 ± 16.07)/(52.24 ± 14.48)

89

97

NTG

-

ORA

GAT: (14.94 ± 3.27)/ICare: (14.71 ± 3.19)

Ayala, 2011 [27]

Retrospective, cross-sectional study

Sweden

-

M/F

Control: (67 ± 9)/POAG: (62 ± 13)/PXSG: (71 ± 9)

30

30/30

POAG/PXSG

-

ORA

POAG: (16.4 ± 4.6)/PXSG: (17.5 ± 5.6)

Detry, 2012 [28]

Observational cross-sectional study

Belgium

African, Caucasian

M/F

African: (43.9 ± 11.4)/(53.8 ± 12.7)

Caucasian: (58.4 ± 14.7)/(70.6 ± 9.2)

55

59

POAG

-

ORA

African: (18.0 ± 5.0) Caucasian: (16.4 ± 3.7)

Grise, 2012 [29]

Retrospective, cross-sectional study

France

-

-

Control: (57.5 ± 5.9)/NTG: (56.1 ± 5.1)/POAG: (59.9 ± 4.9)

44

28/75

NTG/POAG

-

ORA

NTG: (13.0 ± 2.63)/POAG: (18.0 ± 4.42)

Morales, 2022 [33]

Observational cross-sectional study

Spain

-

M/F

Unclear(> 18 years of age)

40

40

PCG

-

ORA

-

Jung, 2020 [31]

Retrospective cross-sectional study

Korea

-

M/F

Control: (56.19 ± 12.45)/POAG: (55.13 ± 15.65)/EXG: (57.77 ± 13.00)

61

46/54

POAG/NTG

32/38a

Corvis ST

-

Miki, 2020 [30]

Retrospective cross-sectional study

Japan

-

-

(56.4 ± 13.2)/(52.7 ± 14.6)

35

35

NTG

-

Corvis ST

15.6 ± 2.8

Hussnain, 2015 [32]

Retrospective, cross-sectional study

The United States

-

-

(61.59 ± 16.56)/(70.73 ± 11.33)

1418

322

POAG

-

ORA

-

Reznicek, 2013 [34]

Prospective observational study

German

-

-

Control: (55.4 ± 15.5)/ OAG: (63.1 ± 13.9)

36

142/106/14/22

OAG/POAG/NTG/PEXG

-

Corvis ST

OAG: (15.4 ± 6.1)/POAG: (16.5 ± 7.2)/NTG: (11.1 ± 1.5)/PEXG: (13.9 ± 3.5)

  1. -: not mentioned
  2. ORA Ocular Response Analyzer, Corvis ST Corneal Visualization Scheimpflug Technology instrument, IOPGAT intraocular pressure of Goldmann applanation tonometry, M/F including male and female, PCG primary congenital glaucoma, GLC glaucoma, OAG open-angle glaucoma, POAG primary open-angle glaucoma, EXG exfoliative glaucoma, PEXG pseudoexfoliative glaucoma, NTG normal-tension glaucoma, PACG primary angle-closure glaucoma, PXSG pseudoex-foliative glaucoma
  3. aJung et al. showed that 32 and 38 patients respectively used the prostaglandin analogues in the POAG and EXG group in their study