Table 2 Subgroup analyses of CCT, CH and CRF
From: Changes in corneal biomechanics in patients with glaucoma: a systematic review and meta-analysis
| Â | Â | Â | Â | Â | Heterogeneity | Â | Â | Â | |
|---|---|---|---|---|---|---|---|---|---|
|  |  | No | MD(95%CI) | Q | I2 | PQ | χ2 | P | |
a. Subgroup analysis of CCT | |||||||||
 Age |  ≥ 18 years old  < 18 years old | 4328 240 | -6.89(-9.61, -4.17) -28.44(-64.71, 7.83) | 52.20 17.55 | 37% 94% | 0.02 0.000 | 4.964 1.54 | 0.000 0.12 | |
 Whether patients were treated for glaucoma | Used medicine Not used medicine Not mentioned | 559 376 3633 | -3.94(-9.51, 1.64) -2.86(-9.35, 3.64) -9.60(-13.71, -5.49) | 0.50 1.12 83.43 | 0% 11% 65% | 0.92 0.29 0.000 | 1.38 0.86 4.58 | 0.17 0.39 0.000 | |
OAG | 178 | -20.00(-37.32, -2.68) | - | - | - | 2.26 | 0.02 | ||
POAG NTG | 1895 1035 | -6.59(-10.86,-2.32) -5.97(-10.00, -1.94) | 22.56 7.85 | 38% 11% | 0.07 0.35 | 3.03 2.90 | 0.002 0.004 | ||
 The type of glaucoma | PCG GLC | 410 170 | -18.11(-40.65, 4.43) -5.00(-16.14, 6.14) | 25.99 - | 88% - | 0.000 - | 1.57 0.88 | 0.12 0.38 | |
EXG PACG PXSG | 409 411 60 | -9.48 (-28.43,9.47) -7.68(-14.72, -0.64) -3.00(-13.63, 7.63) | 17.46 0.14 - | 83% 0% - | 0.000 0.71 - | 0.98 2.14 0.55 | 0.33 0.03 0.58 | ||
 The type of machine | ORA Corvis ST ORA and Corvis ST | 3573 720 275 | -7.48(-11.42,-3.55) -11.34(-19.87, -2.80) -11.85(-25.18, 1.47) | 76.00 10.90 2.34 | 66% 45% 57% | 0.000 0.09 0.13 | 3.73 2.60 1.74 | 0.000 0.009 0.08 | |
b. Subgroup analysis of CH | |||||||||
 Age |  ≥ 18 years old  < 18 years old Not clearly defined | 4564 240 221 | -1.39(-1.72, -1.06) -2.48(-2.90, -2.06) -2.86(-3.37, -2.35) | 196.47 0.61 - | 88% 0% - | 0.000 0.43 - | 8.30 11.46 10.93 | 0.000 0.000 0.000 | |
 Whether patients were treated for glaucoma | Used medicine Not used medicine Not mentioned | 337 376 4312 | -1.07(-1.37, -0.77) -0.66(-1.42, 0.11) -1.68(-2.07, -1.28) | 0.21 6.01 238.11 | 0% 83% 91% | 0.65 0.01 0.000 | 6.95 1.69 8.27 | 0.000 0.09 0.000 | |
POAG NTG | 2955 728 | -1.14(-1.49,-0.79) -0.91(-1.49, -0.33) | 53.11 21.04 | 79% 86% | 0.000 0.000 | 6.40 3.06 | 0.000 0.002 | ||
 The type of glaucoma | PCG GLC | 631 170 | -2.71(-3.01, -2.41) -1.60(-2.06, -1.14) | 3.00 - | 0% - | 0.56 - | 17.88 6.86 | 0.000 0.000 | |
EXG PACG PXSG | 351 130 60 | -2.66 (-3.45, -1.88) -0.20(-0.70, 0.30) -1.80(-2.58, -1.02) | 7.98 - - | 75% - - | 0.02 - - | 6.64 0.78 4.50 | 0.000 0.44 0.000 | ||
 The type of machine | ORA Corvis ST ORA and Corvis ST | 4750 - 275 | -1.59(-1.96,-1.21) - -1.08(-1.37, -0.80) | 265.29 - 0.26 | 91% - 0% | 0.000 - 0.61 | 8.24 - 7.42 | 0.000 - 0.000 | |
c. Subgroup analysis of CRF | |||||||||
 Age |  ≥ 18 years old  < 18 years old Not clearly defined | 2358 240 221 | -0.71(-1.10, -0.31) -1.68(-3.32, -0.03) -1.17(-1.81, -0.53) | 109.33 12.40 - | 84% 92% - | 0.000 0.000 - | 3.49 2.00 3.57 | 0.000 0.05 0.000 | |
 Whether patients were treated for glaucoma | Used medicine Not used medicine Not mentioned | 201 376 2242 | -0.61(-1.16, -0.06) -0.77(-1.25, -0.29) -0.84(-1.31, -0.38) | - 1.84 138.37 | - 46% 88% | - 0.18 0.000 | 2.16 3.16 3.55 | 0.03 0.002 0.000 | |
POAG NTG | 819 728 | -0.31(-1.11, 0.48) -1.02(-1.54, -0.51) | 46.62 12.99 | 87% 77% | 0.000 0.005 | 0.78 3.91 | 0.44 0.000 | ||
 The type of glaucoma | PCG GLC | 631 170 | -1.47(-2.12, -0.81) -0.90(-1.44, -0.36) | 15.94 - | 75% - | 0.003 - | 4.40 3.24 | 0.000 0.001 | |
EXG PACG PXSG | 351 130 - | -1.14 (-2.34, 0.05) 0.70(-0.00, 1.40) - | 15.27 - - | 87% - - | 0.000 - - | 1.87 1.95 - | 0.06 0.05 - | ||
 The type of machine | ORA Corvis ST ORA and Corvis ST | 2680 - 139 | -0.80(-1.20,-0.40) - -1.34(-1.95, -0.73) | 139.97 - - | 86% - - | 0.000 - - | 3.89 - 4.31 | 0.000 - 0.000 | |