- Case report
- Open Access
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Choroidal neovascularization in angioid streaks following microincision vitrectomy surgery: a case report
© Katagiri et al.; licensee BioMed Central Ltd. 2013
- Received: 25 December 2012
- Accepted: 2 July 2013
- Published: 5 July 2013
Patients with angioid streaks are prone to developing subretinal hemorrhage after ocular or head injury due to the brittleness of Bruch’s membrane. However, there have been no reports of any angioid streak patients in whom choroidal neovascularization occurred after vitrectomy surgery. We report herein a patient with angioid streaks who developed choroidal neovascularization after vitrectomy surgery for epiretinal membrane.
A 76-year-old man presented with distorted vision in his left eye, with a best corrected visual acuity of 1.2 and 0.6 in his right and left eyes, respectively. Fundus examination showed angioid streaks in both eyes and epiretinal membrane only in the left eye. The patient underwent 23-gauge three-port pars plana vitrectomy with removal of the epiretinal membrane combined with cataract surgery. Internal limiting membrane in addition to the epiretinal membrane were successfully peeled and removed, with indocyanine green dye used to visualize the internal limiting membrane. His left best corrected visual acuity improved to 0.8. An elevated lesion with retinal hemorrhage due to probable choroidal neovascularization was found between the fovea and the optic disc in the left eye at 7 weeks after surgery. Since best corrected visual acuity decreased to 0.15 and the hemorrhage expanded, posterior sub-Tenon injection of triamcinolone acetonide was performed. However, no improvement was observed. Even though intravitreal bevacizumab injection was performed a total of five times, his best corrected visual acuity remained at 0.1. Subsequently, we performed a combination treatment of a standard-fluence photodynamic therapy and intravitreal ranibizumab injection, with additional intravitreal ranibizumab injections performed 3 times after this combination treatment. Best corrected visual acuity improved to 0.5 and the size of the choroidal neovascularization markedly regressed at 4 months after the combined treatment.
Development of choroidal neovascularization could possibly occur in elderly patients with angioid streaks after vitrectomy surgery. In such cases, a combination of photodynamic therapy and intravitreal ranibizumab injection may be considered for initial treatment of the choroidal neovascularization.
- Angioid streaks
- Choroidal neovascularization
- Vitrectomy surgery
- Anti-vascular endothelial growth factor treatment
- Photodynamic therapy
- Pseudoxanthoma elasticum
Angioid streaks (AS) are visible irregular crack-like dehiscences radiating from the optic nerve to the peripheral retina. Approximately 70% of AS patients have pseudoxanthoma elasticum (PXE) characterized by changes in the elastic tissue of the skin . Patients with AS are usually asymptomatic unless the lesions extend towards the fovea or develop complications such as traumatic Bruch’s membrane rupture or choroidal neovascularization (CNV). Several studies on the relationship between ocular trauma and subretinal hemorrhage in patients with AS have been reported [2, 3]. There is also a report of an AS patient who developed CNV after indirect trauma to the eye itself . It has also been reported that 15% of AS patients who suffer head injuries develop significant visual impairment . However, to our knowledge, there have been no reports of any AS patients in whom CNV occurred after vitrectomy surgery.
We report herein a case of an AS patient in whom CNV occurred at 7 weeks after microincision vitrectomy surgery for removal of epiretinal membrane (ERM).
In this report, we describe a single AS patient in whom CNV developed 7 weeks after vitrectomy surgery for ERM. To date, there have been no other reports of any AS patients who have developed CNV after vitrectomy surgery.
Numerous studies have reported the incidence of CNV to vary between 72%–86% in AS patients . It is reported that the risk of developing CNV increases with age . Other risk factors comprise the width, length and location of the AS. Several studies have reported that wider and longer AS are associated with higher risk of CNV, and that the risk of CNV development is especially higher if AS are located within one optic disc diameter from the foveola [5, 7, 8].
As an external factor, ocular trauma can be a risk factor for the development of subretinal hemorrhage [2, 3]. In fact, AS patients are likely to develop breaks of Bruch’s membrane even after relatively mild ocular head injuries, since their Bruch’s membrane is brittle . In addition, it has also been reported that an AS patient developed CNV 4 months after an indirect ocular trauma . Thus, it is possible that CNV can occur due to either direct or indirect ocular trauma.
Regarding the relationship between vitrectomy surgery and CNV development, there have been some studies that have reported finding CNV after vitrectomy surgery for idiopathic macular hole [9–12]. Although the pathogenesis underlying the development of CNV after macular hole surgery has yet to be completely clarified, it has been suggested that the most plausible explanation is an age-related degenerative change in the retinal pigment epithelium (RPE) and Bruch’s membrane. This is supported by the fact that there is a higher prevalence of CNV development after macular hole surgery in older patients [10, 13]. In addition, as has been reported in a previous study, mechanical trauma during the ILM peeling in the macular hole surgery might have played a role in the pathogenesis of the CNV that subsequently developed in the patient . In fact, this is similar to the current case, as our patient had brittleness of Bruch’s membrane and RPE because of AS and aging and thus, underwent vitrectomy surgery with ERM and ILM peeling, after which he developed CNV.
When treating CNV secondary to AS, previous studies have described the use of monotherapy treatments employing PDT or anti-VEGF therapies. For example, Arias et al. reported that PDT was not effective in the treatment of CNV in the macula , while Browning et al. showed that PDT delayed, but did not permanently prevent visual loss associated with the CNV in AS . However, in other cases it has been reported that injection of intravitreal bevacizumab (IVB) was effective as a long-term control tool for CNV associated with AS [16, 17]. Moreover, it has been reported that IVR was also effective in treating CNV associated with AS [18–20]. Even so, after the patient in the current case received 5-time IVB injections, the CNV remained active. This suggested that there was a decrease in the biologic effect after repeated intravitreal anti-VEGF injections of the same drug, such as bevacizumab [21–23]. An in vitro experiment demonstrated that the absence or presence of hyaluronan, which is a major component in the vitreous body, may be associated with the clinical efficacy of IVB because of the higher affinity of hyaluronan for bevacizumab as compared to that for ranibizumab . Christoforidis et al. revealed that clearance rates for intravitreally placed bevacizumab or ranibizumab in vitrectomized or lensectomized rabbit model eyes are faster than those in control eyes . Based on these previous findings in conjunction with the bevacizumab tachyphylaxis and the vitrectomized-pseudophakic condition that was present, we decided to use ranibizumab instead of bevacizumab in all of the subsequent treatments for this patient. Recently, it has been reported that the combination of IVR and reduced-fluence PDT for CNV associated with AS was effective in the regression of CNV and in improving (or stabilizing) the visual acuity [26, 27]. Based on the above-mentioned findings, we performed the combined therapy of full-dose PDT and IVR instead of IVR monotherapy. Our current results support the effectiveness of the combined therapy, as the combination therapy of full-dose PDT and IVR was effective, with improvement of the visual acuity and regression of the CNV ultimately seen in our patient.
Development of CNV can occur in elderly patients with AS after vitrectomy surgery. In such cases, the combination of PDT and anti-VEGF therapies may be considered for use as the initial treatment of CNV.
Written informed consent was obtained from the patient for publication of this case report and any accompanying images. A copy of the written consent is available for review by the Editor of this journal.
This study was supported by grants from the Ministry of Health, Labor and Welfare of Japan (T.H.) and the Vehicle Racing Commemorative Foundation (T.H.).
- Connor PJ, Juergens JL, Perry HO, Hollenhorst RW, Edwards JE: Pseudoxanthoma elasticum and angioid streaks. A review of 106 cases. Am J Med. 1961, 30: 537-543. 10.1016/0002-9343(61)90078-X.View ArticlePubMedGoogle Scholar
- Britten MJ: Unusual traumatic retinal haemorrhages associated with angioid streaks. Br J Ophthalmol. 1966, 50: 540-542. 10.1136/bjo.50.9.540.View ArticlePubMedPubMed CentralGoogle Scholar
- Levin DB, Bell DK: Traumatic retinal hemorrhages with angioid streaks. Arch Ophthalmol. 1977, 95: 1072-1073. 10.1001/archopht.1977.04450060159017.View ArticlePubMedGoogle Scholar
- Pandolfo A, Verrastro G, Piccolino FC: Retinal hemorrhages following indirect ocular trauma in a patient with angioid streaks. Retina. 2002, 22: 830-831. 10.1097/00006982-200212000-00035.View ArticlePubMedGoogle Scholar
- Georgalas I, Papaconstantinou D, Koutsandrea C, Kalantzis G, Karagiannis D, Georgopoulos G, Ladas I: Angioid streaks, clinical course, complications, and current therapeutic management. Ther Clin Risk Manag. 2009, 5: 81-89.PubMedPubMed CentralGoogle Scholar
- Shilling JS, Blach RK: Prognosis and therapy of angioid streaks. Trans Ophthalmol Soc U K. 1975, 95: 301-306.PubMedGoogle Scholar
- Mansour AM, Ansari NH, Shields JA, Annesley WH, Cronin CM, Stock EL: Evolution of angioid streaks. Ophthalmologica. 1993, 207: 57-61. 10.1159/000310407.View ArticlePubMedGoogle Scholar
- Mansour AM, Shields JA, Annesley WH, el-Baba F, Tasman W, Tomer TL: Macular degeneration in angioid streaks. Ophthalmologica. 1988, 197: 36-41. 10.1159/000309915.View ArticlePubMedGoogle Scholar
- Natarajan S, Mehta HB, Mahapatra SK, Sharma S: A rare case of choroidal neovascularization following macular hole surgery. Graefes Arch Clin Exp Ophthalmol. 2006, 244: 271-273. 10.1007/s00417-005-0004-9.View ArticlePubMedGoogle Scholar
- Oh HN, Lee JE, Kim HW, Yang JW, Yun IH: Occult choroidal neovascularization after successful macular hole surgery treated with ranibizumab. Clin Ophthalmol. 2012, 6: 1287-1291.PubMedPubMed CentralGoogle Scholar
- Tabandeh H, Smiddy WE: Choroidal neovascularization following macular hole surgery. Retina. 1999, 19: 414-417. 10.1097/00006982-199909000-00008.View ArticlePubMedGoogle Scholar
- Berinstein DM, Hassan TS, Williams GA, Margherio RR, Ruby AJ, Garretson BR: Surgical repair of full-thickness idiopathic macular holes associated with significant macular drusen. Ophthalmology. 2000, 107: 2233-2239. 10.1016/S0161-6420(00)00417-6.View ArticlePubMedGoogle Scholar
- Tabandeh H, Smiddy WE, Sullivan PM, Monshizadeh R, Rafiei N, Cheng L, Freeman W: Characteristics and outcomes of choroidal neovascularization occurring after macular hole surgery. Retina. 2004, 24: 714-720. 10.1097/00006982-200410000-00005.View ArticlePubMedGoogle Scholar
- Arias L, Pujol O, Rubio M, Caminal J: Long-term results of photodynamic therapy for the treatment of choroidal neovascularization secondary to angioid streaks. Graefes Arch Clin Exp Ophthalmol. 2006, 244: 753-757. 10.1007/s00417-005-0131-3.View ArticlePubMedGoogle Scholar
- Browning AC, Chung AK, Ghanchi F, Harding SP, Musadiq M, Talks SJ, Yang YC, Amoaku WM, United Kingdom PDTUG: Verteporfin photodynamic therapy of choroidal neovascularization in angioid streaks: one-year results of a prospective case series. Ophthalmology. 2005, 112: 1227-1231. 10.1016/j.ophtha.2005.02.011.View ArticlePubMedGoogle Scholar
- Teixeira A, Moraes N, Farah ME, Bonomo PP: Choroidal neovascularization treated with intravitreal injection of bevacizumab (Avastin) in angioid streaks. Acta Ophthalmol Scand. 2006, 84: 835-836. 10.1111/j.1600-0420.2006.00762.x.View ArticlePubMedGoogle Scholar
- Derriman L, Marshall J, Moorman C, Downes SM: The use of intravitreal bevacizumab to treat choroidal neovascular membranes (CNVMs). Retina. 2008, 28: 910-author reply 910–911View ArticlePubMedGoogle Scholar
- Mimoun G, Tilleul J, Leys A, Coscas G, Soubrane G, Souied EH: Intravitreal ranibizumab for choroidal neovascularization in angioid streaks. Am J Ophthalmol. 2010, 150: 692-700. 10.1016/j.ajo.2010.06.004. e691View ArticlePubMedGoogle Scholar
- Kang S, Roh YJ: Intravitreal ranibizumab for choroidal neovascularisation secondary to angioid streaks. Eye (Lond). 2009, 23: 1750-1751. 10.1038/eye.2009.158.View ArticleGoogle Scholar
- Shah M, Amoaku WM: Intravitreal ranibizumab for the treatment of choroidal neovascularisation secondary to angioid streaks. Eye (Lond). 2012, 26: 1194-1198. 10.1038/eye.2012.116.View ArticleGoogle Scholar
- Schaal S, Kaplan HJ, Tezel TH: Is there tachyphylaxis to intravitreal anti-vascular endothelial growth factor pharmacotherapy in age-related macular degeneration?. Ophthalmology. 2008, 115: 2199-2205. 10.1016/j.ophtha.2008.07.007.View ArticlePubMedGoogle Scholar
- Keane PA, Liakopoulos S, Ongchin SC, Heussen FM, Msutta S, Chang KT, Walsh AC, Sadda SR: Quantitative subanalysis of optical coherence tomography after treatment with ranibizumab for neovascular age-related macular degeneration. Invest Ophthalmol Vis Sci. 2008, 49: 3115-3120. 10.1167/iovs.08-1689.View ArticlePubMedPubMed CentralGoogle Scholar
- Gasperini JL, Fawzi AA, Khondkaryan A, Lam L, Chong LP, Eliott D, Walsh AC, Hwang J, Sadda SR: Bevacizumab and ranibizumab tachyphylaxis in the treatment of choroidal neovascularisation. Br J Ophthalmol. 2012, 96: 14-20. 10.1136/bjo.2011.204685.View ArticlePubMedGoogle Scholar
- Sugita I, Yoneda M, Iwaki M, Zako M: Comparative Analysis of Hyaluronan’s Affinity for Antivascular Endothelial Growth Factor Agents. Ophthalmic Res. 2012, 49: 43-48.View ArticlePubMedGoogle Scholar
- Christoforidis JB, Williams MM, Wang J, Jiang A, Pratt C, Abdel-Rasoul M, Hinkle GH, Knopp MV: Anatomic and pharmacokinetic properties of intravitreal bevacizumab and ranibizumab after vitrectomy and lensectomy. Retina. 2013, 33: 946-952. 10.1097/IAE.0b013e3182753b12.View ArticlePubMedPubMed CentralGoogle Scholar
- Prabhu VV, Morris RJ, Shah PK, Narendran V: Combination treatment of low fluence photodynamic therapy and intravitreal ranibizumab for choroidal neovascular membrane secondary to angioid streaks in Paget’s disease - 12 month results. Indian J Ophthalmol. 2011, 59: 306-308. 10.4103/0301-4738.82000.View ArticlePubMedPubMed CentralGoogle Scholar
- Artunay O, Yuzbasioglu E, Rasier R, Sengul A, Senel A, Bahcecioglu H: Combination treatment with intravitreal injection of ranibizumab and reduced fluence photodynamic therapy for choroidal neovascularization secondary to angioid streaks: preliminary clinical results of 12-month follow-up. Retina. 2011, 31: 1279-1286. 10.1097/IAE.0b013e318205b228.View ArticlePubMedGoogle Scholar
- The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1471-2415/13/29/prepub
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