Descemet membrane endothelial keratoplasty in cases with existing scleral-sutured and iris-sutured intraocular lenses
© Röck et al.; licensee BioMed Central Ltd. 2014
Received: 12 November 2012
Accepted: 13 January 2014
Published: 20 January 2014
To report two cases of Descemet Membrane Endothelial Keratoplasty (DMEK) in patients with existing scleral-fixated and iris-fixated intraocular lenses (sf-IOL and if-IOL, respectively).
DMEK procedures were performed on a 49-year-old woman with a pre-existing sf-IOL (case 1) and a 69-year-old woman with a pre-existing if-IOL (case 2) in order to treat secondary corneal edema due to pseudophakic bullous keratopathy. Visual acuity, refractive error, intraocular pressure, slit lamp examination, pachymetry measurements and endothelial cell density (ECD) were considered and repeated during follow-ups.
Both cases had no intraoperative complications. At postoperative day 1 graft centration and complete attachment were noted. The IOL positions were unchanged in comparison to their preoperative positions. In case 1, visual acuity improved from 1/15 at 1 meter preoperative to 20/200 within one week and to 20/63 within 12 weeks of follow up. In case 2, visual acuity improved from counting fingers at 1 meter preoperative to 20/200 within one week and to 20/100 within 12 weeks of follow-up. In case 2 a partial graft dislocation was observed at postoperative day twenty. Complete graft re-apposition was achieved by rebubbling procedure performed with intracameral air injection.
DMEK surgery in the treatment of pseudophakic bullous keratopathy in the presence of sf-IOL and if-IOL can successfully be performed. These eyes are at increased risk of IOL dislocation into the vitreous cavity during DMEK surgery.
KeywordsDescemet membrane endothelial keratoplasty (DMEK) Aphakia Bullous keratopathy Transscleral-fixated intraocular lens (sf-IOL) Iris-fixated intraocular lens (if-IOL)
Recently novel techniques of posterior lamellar keratoplasty for the treatment of corneal endothelial diseases (CED) have been developed [1–3]. Lamellar keratoplasty has been shown to offer a promising alternative to penetrating keratoplasty (PK) and has become a popular procedure for the management of CED [2–5].
Descemet Membrane Endothelial Keratoplasty (DMEK) offers several advantages over PK such as its minimal invasiveness, rapid visual rehabilitation, excellent uncorrected and corrected visual acuities and reduction of postsurgical atigmatism [6–8].
Despite the obvious superiority over PK in CED, adequate visualization of the anterior chamber is an important prerequisite to a successful DMEK. The donor tissue’s properties make it liable to intraoperative loss. This is especially true in eyes with extensive iris defects and dilated pupils. The relatively thin donor tissue increases the intraoperative difficulty. The donor tissue is so thin that it can be difficult to unfold and orientate properly onto the donor bed.
Moreover, DMEK may be relatively contraindicated in eyes with unpressurizable anterior chambers . Thus, it may be challenging to perform a DMEK on postvitrectomy eyes and ones with potentially unstable IOLs, such as scleral-fixated and iris-fixated lenses (sf-IOL and if-IOL, respectively). Filling the anterior chamber with air at the end of the procedure could potentially dislocate an unstable IOL.
We present two cases of successful DMEK surgery performed in eyes with pre-existing scleral-sutured and iris-sutured IOLs, that therefore present an increasd risk of IOL dislocation.
The donor corneoscleral rim was placed on a sterile circular surface and was scored and stained with trypan blue to highlight the scoring mark; thereafter, it was placed in a corneal viewing chamber containing corneal storage solution (Culture Medium I; Biochrom AG, Berlin, Germany). A circular incision with a hockey knife was made. Complete dissection of the DMEK tissue from the corneoscleral rim was achieved by grasping the peripheral free tissue flap using untoothed curviliniear forceps specially developed for this task by Yoeruek . A spatula was used to lift the trephinated graft off the stromal bed after complete dissection and trephination. The DM was placed in culture medium before the surgery. At surgery the culture medium was carefully drained and the DMEK roll was thoroughly rinsed with BSS. To open the tissue and create a double roll a direct flow on the top of the tissue with BSS was applied. The tissue was then stained with trypan blue.
The age of the donor in case one was 50 years and in case two 57 years. The mean cellular endothelial count of the tissue was 2700 cells per square millimeter and 2400 cells per square millimeter in case one and two.
Recipient preparation, graft insertion, and positioning
The surgical technique involved the initial placement of two paracentheses in the 2-o’clock and 10 o’clock positions. To remove the recipients’ DM, proper visualization of the anterior chamber using air pressurized at 30 mmHg is needed. This is followed by the introduction of a reversed Sinskey hook through a paracenthesis for Descemetorhexis. A 2.75 mm clear corneal tunnel was created with a 2.75 mm slit knife at the 12 o’clock position. The dissected donor DM was loaded into a shooter (DMEK shooter Geuder AG, Heidelberg, Germany) in the double-roll-form. The injector was turned so that the double roll was facing upward. Implantation took place into a soft eye. After confirmation of orientation, primary using Melles rule of the rolled edges with the endothelium facing outward the anterior chamber was obliterated completely via the paracentheses. No air was injected above or below the DM (to aid in the process of unfolding). The eye was kept in the soft state, and digital pressure was applied at the equatorial plane, thereby preventing any refolding or recurling. Apposition and centration was achieved because of the shallow anterior chamber, the soft eye status, and the corneal tapping in combination with equatorial digital pressurization. After complete unfolding, the infusion of air was placed in the anterior chamber from an infusion pump connected to a 30-gauge cannula. Air is infused into the anterior chamber below the DM at a continuously regulated pressure of 30 mmHg for final DM fixation .
Today, several techniques and different IOL types to treat aphakia have been described. The iris may serve as one point of fixation exemplified by an if-IOL (e.g. Artisan lens). Two options are available, either the anterior or the posterior approach. Because the Artisan lens is not foltable, the use of this lens is restricted to eyes undergoing extended corneoscleral incision with a standard 5.5- to 6-mm corneoscleral tunnel incision at the 12-o’clock position.
In cases of inadequate capsular support, sulcus lenses may be fixated to the sclera. Since the early 1990s, the ab-externo technique of Lewis and the refined ab-interno technique of Smiddy et al are the basis of multiple variations in transscleral suturing [13, 14]. Szurman et al. modified this technique into a knotless one without direct knot exposure and, hence, lessened complications .
The concept of DMEK surgery has been proven by several studies. During the surgery two critical steps, first descemetorhexis under air visualization and second final fixation under air pressurization, pose an increased risk of IOL dislocation especially in cases having if-IOL and sf-IOL implants. When these two steps are preformed there is a risk that the air bubble could exert pressure on the IOL, endangering its stability, with possible malpositioning or even dislocation into the vitreous chamber. The surgeon has to consider these eventualities wisely. Additionally, in post-vitrectomy and sf-IOL cases the air passage is relatively unhindered into the posterior chamber. Air migration into this space may result in extensive irido-corneal adhesions and possibly severe ocular hypertension. Furthermore, considerable mechanical trauma may also be caused at the posterior aspect involving the delicate point of fixation . Air pressure exerted onto the IOL’s surface endangers its stability with subluxation or even dislocation affecting the lenticular system which is especially vulnerable in the early postoperative period.
Lapenna et al. reported a case with dis-enclavation of an iris claw IOL after Descemet Stripping Automated Endothelial Keratoplasty (DSAEK) . Tay et al. have described a similar case in which a silicone plate haptic posterior chamber IOL dislocated into the vitreous cavity after DSAEK in the presence of a posterior capsulotomy .
However, a direct comparison of DSAEK and DMEK in this respect would be incorrect, as the graft’s properties result in longer OR time when using DMEK, especially when applied to vitrectomized eyes. The presence of a thin stromal layer in DSAEK allows for ease of handling of the donor tissue. In absence of the stromal layer the tendency of the donor tissue to roll onto itself makes proper positioning and fixation difficult.
In order to address this issue conveniently, a special maneuver was introduced by us. The maneuver offers complete unfolding of the DM without the need of an additional air bubble above or below the graft. Air is only introduced for the apposition and final fixation. Unfolding was achieved with simultaneous digital pressure in the equatorial region and tapping of the corneal surface. It is an especially helpful maneuver in eyes with a deep anterior chamber as in postvitrectomy eyes .
In conclusion, the presented cases demonstrate the feasibility of DMEK in eyes with sf-IOLs and if-IOLs. The successful outcomes imply that DMEK is not “absolutely contraindicated” in such cases. Nevertheless, a high level of caution is needed in both critical steps as mentioned above. Further studies with a larger series and longer follow-up are required to quantify the complication rates of DMEK in eyes with sf-IOLs and if-IOLs.
Written informed consent was obtained from the patient for publication of this case report and any accompanying images. A copy of the written consent is available for review by the Editor-in-Chief of this journal.
- Price FW, Price MO: Descemet’s stripping with endothelial keratoplasty in 50 eyes: a refractive neutral corneal transplant. J Refract Surg. 2005, 21: 339-345.PubMedGoogle Scholar
- Price FW, Price MO: Descemet’s stripping with endothelial keratoplasty in 200 eyes: early challenges and techniques to enhance donor adherence. J Cataract Refract Surg. 2006, 32: 411-418.3. 10.1016/j.jcrs.2005.12.078.View ArticlePubMedGoogle Scholar
- Price MO, Giebel AW, Fairchild KM, Price FW: Descemet’s membrane endothelial Keratoplasty: prospective multicenter study of visual and refractive outcomes and endothelial survival. Ophthalmology. 2009, 116: 2361-2368. 10.1016/j.ophtha.2009.07.010.View ArticlePubMedGoogle Scholar
- Melles GR, Ong TS, Ververs B, van der Wees J: Descemet membrane endothelial keratoplasty (DMEK). Cornea. 2006, 25: 987-990.View ArticlePubMedGoogle Scholar
- Melles GR: Posterior lamellar keratoplasty: DLEK to DSEK to DMEK. Cornea. 2006, 25: 879-881. 10.1097/01.ico.0000243962.60392.4f.View ArticlePubMedGoogle Scholar
- Cursiefen C, Küchle M, Naumann GO: Changing indications of penetrating keratoplasty: histopathology of 1,250 corneal buttons. Cornea. 1998, 17: 468-470. 10.1097/00003226-199809000-00002.View ArticlePubMedGoogle Scholar
- Terry MA, Ousley PJ: Deep lamellar endothelial keratoplasty visual acuity, astigmatism, and endothelial survival in a large prospective series. Ophthalmology. 2005, 112: 1541-1548. 10.1016/j.ophtha.2005.03.026.View ArticlePubMedGoogle Scholar
- Guerra FP, Anshu A, Price MO, Giebel AW, Price FW: Descemet’s membrane endothelial keratoplasty prospective study of 1-year visual outcomes, graft survival, and endothelial cell loss. Ophthalmology. 2011, 118: 2368-2373. 10.1016/j.ophtha.2011.06.002.View ArticlePubMedGoogle Scholar
- Dapena I, Moutsouris K, Droutsas K, Ham L, van Dijk K, Melles GR: Standardized “no-touch” technique for descemet membrane endothelial keratoplasty. Arch Ophthalmol. 2011, 129: 88-94.View ArticlePubMedGoogle Scholar
- Yoeruek E, Schmidt B: Novel surgical instruments facilitating descemet membrane dissection. Cornea. 2013, 32: 523-526. 10.1097/ICO.0b013e3182588ae9.View ArticlePubMedGoogle Scholar
- Yoeruek E, Bayyoud T, Hofmann J, Bartz-Schmidt KU: Novel maneuver facilitating descemet membrane unfolding in the anterior chamber. Cornea. 2013, 32: 370-373. 10.1097/ICO.0b013e318254fa06.View ArticlePubMedGoogle Scholar
- Szurman P, Petermeier K, Aisenbrey S, Spitzer MS, Jaissle GB: Z-suture: a new knotless technique for transscleral suture fixation of intraocular implants. Br J Ophthalmo. 2010, 94: 167-169. 10.1136/bjo.2009.162180.View ArticleGoogle Scholar
- Lewis JS: Ab externo sulcus fixation. Ophthalmic Surg. 1991, 22: 692-695.PubMedGoogle Scholar
- Smiddy WE, Sawusch MR, O’Brien TP, Scott DR, Huang SS: Implantation of scleral-fixated posterior chamber intraocular lenses. J Cataract Refract Surg. 1990, 16: 691-696. 10.1016/S0886-3350(13)81007-3.View ArticlePubMedGoogle Scholar
- Lapenna L, Kadyan A, Busin M: Intraocular lens exchange 1 week after descemet stripping automated endothelial keratoplasty. Cornea. 2010, 29: 207-209. 10.1097/ICO.0b013e3181a1669e.View ArticlePubMedGoogle Scholar
- Tay E, Rajan MS, Saw VP, Dart JK: Dislocated intraocular lens into the vitreous cavity after DSAEK. J Cataract Refract Surg. 2008, 34: 525-526.View ArticlePubMedGoogle Scholar
- The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1471-2415/14/6/prepub
This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.