- Case report
- Open Access
- Open Peer Review
Systemic adalimumab induces peripheral corneal infiltrates: a case report
© Matet et al. 2015
- Received: 27 January 2014
- Accepted: 29 May 2015
- Published: 6 June 2015
Tumor necrosis factor-alpha inhibitors are widely used agents in the treatment of immune disorders such as rheumatoid arthritis and inflammatory bowel disease. Despite their anti-inflammatory action, paradoxical drug-induced inflammatory events have been occasionally associated with the use of infliximab, etanercept, and in a lesser extent adalimumab. However, eye involvement is uncommon and anterior uveitis is the only reported ocular adverse manifestation. It can be induced by etanercept, but has also been described during adalimumab therapy. We present here the first report of recurrent peripheral corneal infiltrates following subcutaneous injections of adalimumab.
A 34 year-old Caucasian woman with Crohn’s disease presented to the emergency department with bilateral red eyes and discomfort 36 hours after she received her bimonthly dose of subcutaneous adalimumab. Examination revealed bilateral peripheral corneal infiltrates with characteristic features of immune infiltrates. Symptoms and infiltrates regressed after topical corticosteroid therapy, but recurred after each adalimumab injection over the following weeks.
Paradoxical immune reactions associated with tumor necrosis factor-alpha inhibitors may result either from hypersensitivity mechanisms, or from immune-complex deposition via anti-adalimumab antibodies. Both mechanisms could explain this newly described manifestation. Care should be taken to search for corneal infiltrates in the event of red eye symptoms during adalimumab therapy since they respond to topical corticosteroids and do not necessarily prompt the discontinuation of the immunosuppressive therapy.
- Tumor necrosis factor-alpha inhibitor
- Adverse effects
- Peripheral infiltrate
- Crohn's disease
Adalimumab is a recombinant monoclonal antibody that inhibits tumor necrosis factor alpha (TNF-α), a pro-inflammatory cytokine. It is commonly employed for several immune-mediated disorders, including inflammatory bowel disease, ankylosing spondylitis and rheumatoid arthritis, with favorable safety reports [1, 2]. Yet, adverse events are progressively identified. Their diagnosis can be challenging since they often share features with the underlying inflammatory condition for which the drug is prescribed. The most common adverse manifestations include dermatitis, fever, interstitial pneumonia or vasculitis, but ocular involvement is very infrequent. To date, anterior uveitis is the only ocular adverse event registered in the literature . In this report, we describe recurrent and bilateral peripheral corneal infiltrates caused by subcutaneous injections of adalimumab. To the best of our knowledge, this is the first report of adalimumab-induced corneal infiltrates.
A 34 year-old Caucasian woman with Crohn’s disease presented to the eye emergency department at our institution with bilateral red eyes and discomfort. She had been wearing soft daily-wear contact lenses with monthly replacement schedule for the past 10 years. She had stopped wearing them 3 months before her visit as a consequence of fluctuating dry eye symptoms. She also reported a recent episode of interface dermatitis on her right ankle, confirmed by internal medicine specialists. She developed HLA-B27-negative ileal Crohn's disease at age 18, and required two intestinal resections at age 20 and 25 for stricturing disease. Thereafter, inflammation had been satisfactorily controlled by oral azathioprine. At the age of 30, 4 years before her visit to our emergency department, recurrence of clinical symptoms led to a switch from oral azathioprine to subcutaneous adalimumab. She had since been receiving 40 mg of subcutaneous adalimumab every 2 weeks.
Prior to the current episode, the patient had been evaluated biennially for 10 years by her attending ophthalmologist in the context of contact lens use. At each visit, she had been screened for ocular signs related to her inflammatory bowel disease. Her corneal status was unremarkable at all examinations. In particular, the patient did not have any history of meibomian gland disease or marginal keratitis.
The features and timing of these recurrences strongly point to adalimumab injections as their causative factor. To the best of our knowledge, there is no previous report of peripheral corneal inflammation secondary to adalimumab.
The infiltrates could have been a manifestation of the inflammatory bowel disease itself. Ocular manifestations during Crohn’s disease indeed include scleritis, episcleritis, uveitis and less frequently peripheral corneal infiltrates, that may complicate sceritis [5, 6]. However, scleritis was absent in this case, and Crohn’s disease was quiescent. In fact, the residual serum level of adalimumab fell within therapeutic range , indicating efficient disease control.
Soft contact lens wear is unlikely to be the source of the peripheral infiltrates in this patient, since they had been discontinued 3 months before the onset of eye redness and discomfort. Intact corneal epithelium over the infiltrates and efficient control by steroids also rule out infectious keratitis. The absence of eyelid inflammation and the timing of recurrences do not support the hypotheses of meibomian gland disease, marginal keratitis or phlyctenulosis.
Ironically, TNF-α inhibitors are known to generate adverse inflammatory reactions despite their immunosuppressive action. Among them, adalimumab induces 3.5 % of hypersensitivity events, the lowest rate within this therapeutic class . Cutaneous manifestations are the most frequent. They include type I hypersensitivity reactions at injection sites , paradoxical inflammation leading to “psoriasiform” lesions  and various types of dermatitis including interface dermatitis , as developed by our patient. Some reports also point to adalimumab as the causative agent in drug-induced interstitial pneumonia [11, 12], fever  or vasculitis [14, 15]. Yet, ocular adverse events have been rarely described following adalimumab, and the only reported manifestation is acute anterior uveitis .
Remarkably, in a recent United States-based registry analysis of uveitis induced by TNF-α inhibitors, adalimumab accounted for only 3 % of cases, far less than infliximab (24 %) and etanercept (73 %) . Scleritis has also been described after etanercept , but not after adalimumab or infliximab. However, except for etanercept these agents are considered safe enough for the treatment of refractory inflammatory eye disease, including peripheral ulcerative keratitis , scleritis  and uveitis [19, 20].
Regarding its pathogenic mechanism, the formation of peripheral corneal infiltrates usually requires either immune-complex deposition or type III hypersensitivity . In this patient, the presence of anti-adalimumab antibodies was very unlikely, since they would have been associated with low drug serum levels and treatment failure due to the neutralization of adalimumab molecules . For this reason, laboratory testing was technically not feasible because the high residual adalimumab level would have neutralized any circulating anti-adalimumab antibodies.
In this report, the patient developed symptomatic, recurrent corneal peripheral infiltrates after repeated subcutaneous administration of adalimumab, a TNF-α inhibitor. These infiltrates resulted either from an immune reaction to adalimumab, or from a paradoxical exacerbation of Crohn’s disease following adalimumab injections. Given the growing number of individuals under TNF-α inhibitor therapy, sterile corneal infiltrates should be meticulously looked for in the event of red eye symptoms. They respond to topical corticosteroid therapy without discontinuation of adalimumab.
Written informed consent was obtained from the patient for publication of this Case report and any accompanying images. A copy of the written consent is available for review by the Editor of this journal.
We wish to thank the patient for allowing us to report the case, and Dr Kattayoon Hashemi from the Cornea and Refractive surgery Unit, Jules-Gonin Eye Hospital, Lausanne, Switzerland, for proofreading the manuscript.
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