Skip to main content
Fig. 3 | BMC Ophthalmology

Fig. 3

From: Wakayama symposium: role of canonical Notch signaling in conjucntival goblet cell differentiation and dry eye syndrome

Fig. 3

A proposed model depicts that canonical Notch signaling augments the expression of Klf4/5, resulting in conjunctival goblet cell differentiation by down-regulating proliferation and up-regulating transcription of Muc 5/ac in conjunctival epithelium. However, OSdnMAML1 blocks canonical Notch pathway, down-regulates Klf4/5, impairs Muc 5/ac synthesis and abrogates goblet cell differentiation (Courtesy of Development)

Back to article page

BMC Ophthalmology

ISSN: 1471-2415

Contact us