- Case report
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Management of intraocular pressure elevation during hemodialysis of neovascular glaucoma: a case report
© Frezzotti et al. 2016
- Received: 24 July 2015
- Accepted: 28 February 2016
- Published: 5 March 2016
It is generally accepted that dialysis may lower plasma osmolality at a faster rate than changes in ocular osmolality. This osmotic difference causes water to migrate from the plasma into the aqueous humor, increasing intraocular pressure. Certain authors have described IOP increase in patients with narrow angles.
Here we report a neovascular glaucoma patient who experienced a substantial increase in IOP associated with severe eye pain and blurred vision during sessions of dialysis. The patient had been refractory to several antiglaucoma drugs and improved after intravenous administration of 20 % hyperosmotic glucose solution with dialysis and pan-retinal photocoagulation.
It is the first report in which intravenous glucose administration and reduction of neovascularization by argon laser pan-retinal photocoagulation successfully managed IOP increase during dialysis in neovascular glaucoma. Further clinical studies are required to confirm our results.
- Neovascolar glaucoma
- Intra ocular pressure
Eye complications may occur during or after hemodialysis in patients with end stage renal disease . Ocular hypertension has been reported in subjects without glaucoma [2–5] and is more accentuated in patients with glaucoma [6, 7]. Reports of intraocular pressure (IOP) rise during dialysis in neovascular glaucoma are extremely limited . It is generally accepted that dialysis may lower plasma osmolality at a faster rate than changes in ocular osmolality. This osmotic difference causes water to migrate from the plasma into the aqueous humor, increasing intraocular pressure . This theory has not however been clearly demonstrated and some studies have indicated that IOP increase is minimal or non existent, probably due to improvement in dialysis techniques.  Certain authors have described IOP increase in patients with narrow angles [11, 12]. Here we report a neovascular glaucoma patient who experienced a substantial increase in IOP associated with severe eye pain and blurred vision during sessions of dialysis. The patient had been refractory to several antiglaucoma drugs and improved after intravenous administration of 20 % hyperosmotic glucose solution with dialysis and pan-retinal photocoagulation. To our knowledge this is the first report in which intravenous glucose administration and reduction of neovascularization by argon laser pan-retinal photocoagulation successfully managed neovoscalar glaucoma.
Intraocular pressure may increase during hemodialysis, as reported in many patients with and without glaucoma. Many mechanisms have been invoked to explain this phenomenon [1–12], the most frequent being that IOP increases due to a rapid fall in plasma osmolality that stimulates increased formation of aqueous humor [2, 3, 9, 13]. This relationship between plasma osmolality and IOP during hemodialysis has been studied since the report of Sitprija et al. [14, 15]. Some authors have suggested that decreased aqueous outflow might be the mechanism of intradialytic IOP increase, since most patients who showed IOP elevation during dialysis also had a narrow anterior chamber angle [16, 17]. Rever et al.  reported that anterior chamber depth decreased significantly during dialysis. In the present neovascular glaucoma patient, we suggest that raised IOP resulted from an imbalance between aqueous outflow, obstructed by angle closure due to new blood vessels, and production of aqueous humor. The rise in IOP during dialysis sustains this explanation: the drainage system was unable to compensate the increase in aqueous production during dialysis. Argon laser retinal photocoagulation is known to reduce angle neovascularization induced by peripheral retinal ischemia in neovascular glaucoma patients [19, 20].
Several therapeutic solutions have been recommended to prevent a symptomatic increase in IOP during dialysis sessions. Medical expedients include topical and systemic carbonic anhydrase inhibitor, which is relatively contraindicated in dialysis patients as it can precipitate severe metabolic acidosis, which might be fatal to patients with end-stage renal disease . Seo et al.  used an oral hypertonic solution with glycerol that proved effective for IOP control and safer in glaucoma patients. Other therapeutic approaches were described by Jaeger et al. who administered intravenous mannitol, which reduced IOP but predisposed patients to various side effects . Other solutions include medical therapy with topical Beta blockers , argon laser trabeculoplasty for exfoliative glaucoma , Ahmed valve implant for neovascular glaucoma  and trabeculectomy for diabetic retinopathy . In our case, elevated IOP levels during hemodialysis were refractory to topical treatments and the patient’s young age and neovascular glaucoma are both well-known risk factors for bleb fibrosis and surgical failure [23, 24].
Intravenous glucose administration was recently proposed to manage IOP increase during dialysis . The authors showed that administration of 20 % glucose solution (100 mL/h) at each dialysis session prevented increased production of aqueous humor due to relative serum hypo-osmolality. After this change of treatment IOP remained in the normal range. One limitation of high glucose administration could be the overall increase in serum glucose in diabetic patients. The most important side effect to be examined, in patients with chronic kidney failure, is that chronic use of hyperosmotic solutions does not reduce the effectiveness of hemodialysis. Effectiveness of hemodialysis is calculated by artificial kidney’s software and it depends on three parameters: BUN values before and after hemodialysis sessions; body weight; time of hemodialysis sessions. In our experience effectiveness of hemodialysis has not changes until now and in literature there aren’t studies on chronic use of hyperosmotic solutions in these type of patients. Another important side effect to be examined is the possible establishment of hyperglycemia but also in this case literature has not provided us more information due to poor series but our patient has not had alterations on glycemia values or on glucose intolerance and performs bi-weekly all tests blood needed.
Before attempting surgery we decided to administer intravenous glucose and to perform argon laser treatment of ischemic peripheral retinal areas to reduce neovascularization of the occluded angle. The synergy of the two treatments, one aimed at reducing the production of aqueous humor and the other at improving its outflow, proved effective in controlling IOP during the dialysis session and was safe for our neovascular glaucoma patient with end-stage renal disease.
Our case of recurrent painful IOP spikes during dialysis in a patient with neovascular glaucoma unresponsive to conventional medical treatment is the first report in which intravenous glucose administration and reduction of neovascularization by argon laser pan-retinal photocoagulation successfully managed IOP increase during dialysis. Further clinical studies are required to confirm our results.
The patient has given a written consent for the publication of this case report.
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- Evans RD, Rosner M. Ocular abnormalities associated with advanced kidney disease and hemodialysis. Semin Dial. 2005;18:252–7.View ArticlePubMedGoogle Scholar
- Burn RA. Intraocular pressure during hemodialysis. Br J Ophthalmol. 1973;57:511–3.View ArticlePubMedPubMed CentralGoogle Scholar
- Leiba H, Oliver M, Shimshomi M, Bar-Khayim Y. Intraocular pressure fluctuations during regular hemodialysis and ultrafiltration. Acta Ophthalmol. 1990;68:320–2.View ArticleGoogle Scholar
- Jung SK, Lee SK, Kim JH. Intraocular pressure change by hemodialysis. J Korean Ophthalmol Soc. 1995;36:2195–201.Google Scholar
- Choong YF, Menage MJ. Symptomatic acute raised IOP following hemodialysis in a patient with end stage renal failure. Br J Ophthalmol. 1998;82:1342–50.PubMedGoogle Scholar
- Masuda H, Shibuya Y, Ohira A. Markedly increased unilateral intraocular pressure during hemodialysis in a patient with ipsilateral exfoliative glaucoma. Am J Ophthalmol. 2000;129:534–6.View ArticlePubMedGoogle Scholar
- Ikeda N, Saito T, Hayasaka S, Hayasaka Y. Unilateral symptomatic elevation of intraocular pressure and prevention using a hyperosmotic agent during hemodialysis. Jpn J Ophthalmol. 2001;45:6559–61.Google Scholar
- Song WK, Ha SJ, Yeom HY, Seoung GJ, Hong YJ. Recurent intraocular pressure elevation during hemodialysis in a patient with neovascular glaucoma. Korean J Ophthalmol. 2006;20:109–12.View ArticlePubMedPubMed CentralGoogle Scholar
- Tawara A, Kobata H, Fujisawa K, Abe T, Ohnishi Y. Mechanism of intraocular pressure elavation during hemodialysis. Curr Eye Res. 1998;17:339–47.View ArticlePubMedGoogle Scholar
- Levy J, Tovbin D, Lifshitz T, Zlotnik M, Tessler Z. Intraocular pressure during haemodialysis: a review. Eye. 2005;19:1249–56.View ArticlePubMedGoogle Scholar
- De Marchi S, Cechin E, Tesio F. Intraocular pressure changes during hemodialysis: prevention of excessive dialytic rise and development of severe metabolic acidosis following acetazolamide therapy. Ren Fail. 1989;11:117–24.View ArticlePubMedGoogle Scholar
- Jaeger P, Morisod L, Wauters JP, Faggioni R. Prevention of glaucoma during hemodialysis by mannitol and acetazolamide. N Engl J Med. 1980;18:702.Google Scholar
- Brusini P. Clinical use of a new method for visual field damage classification in glaucoma. Eur J Ophthalmol. 1996;6:402–7.PubMedGoogle Scholar
- Tokuokuyama T, Ikeda T, Sato K. Effect of plasma colloid osmotic pressure on intraocular pressure during hemodialysis. Br J Ophthalmol. 1998;82:751–3.View ArticleGoogle Scholar
- Sitprija V, Holmes JH. Preliminary observations on the change in intracranial pressure and intraocular pressure during hemodialysis. Trans Am Soc Artif Intern Organs. 1962;8:300–8.View ArticlePubMedGoogle Scholar
- Sitprija V, Holmes JH, Ellis PP. Changes in intraocular pressure during hemodialysis. Invest Ophthalmol. 1964;3:273–84.PubMedGoogle Scholar
- Jaeger P, Morisod L, Wauters JP, Faggioni R. Prevention of glaucoma during hemodialysis by mannitol and acetazolamide. N Engl J Med. 1980;303:70–6.Google Scholar
- Rever B, Fox L, Christensen R, Bar-Khayim Y, Nissenson AR. Adverse ocular effects of acetate hemodialysis. Am J Nephrol. 1983;3:199–204.View ArticlePubMedGoogle Scholar
- Laatikainen L. A prospective follow-up study of panretinal photocoagulation in preventing neovascular glaucoma following ischaemic central retinal vein occlusion. Graefes Arch Clin Exp Ophthalmol. 1983;220(5):236–9.View ArticlePubMedGoogle Scholar
- Weber PA. Neovascular glaucoma. Current management. Surv Ophthalmol. 1981;26(3):149–53.View ArticlePubMedGoogle Scholar
- Seo SG, Kim YI, Kim YW, Yun IH. A study of intraocular pressure during hemodialysis in CRF patients. J Korean Ophthalmol Soc. 2002;43:1222–9.Google Scholar
- Sawaki W, Kinouchi R, Kato Y, Takahashi T, Kawai M, Yoshida A. Case in which the unilateral intraocular pressure before hemodialysis was higher than the day following hemodialysis. Hokkaido Igaky Zasshi. 2009;84:5–8.Google Scholar
- Ma KT, Yang JY, Kim JH, Kim NR, Hong S, Lee ES, Seong GJ, Kim CY. Surgical results of Ahmed valve implantation with intraoperative bevacizumab injection in patients with neovascular glaucoma. J Glaucoma. 2012;21(5):331–6.View ArticlePubMedGoogle Scholar
- Elmekawey H, Khafagy A. Intracameral ranibizumab and subsequent mitomycin C augmented trabeculectomy in neovascular glaucoma. J Glaucoma. 2014;23(7):437–40.View ArticlePubMedGoogle Scholar
- Saritas T, Koutsonas A, Walter P, Floege J, Krüger T. Management of intraocular hypertension during hemodialysis by intravenous glucose administration. Am J Kidney Dis. 2014;63(3):500–2.View ArticlePubMedGoogle Scholar