Associations between matrix metalloproteinase gene polymorphisms and glaucoma susceptibility: a meta-analysis

BMC Ophthalmology

Table 4 Summary ORs and 95% CI of MMP-1 rs1799750 1G > 2G and MMP-2 rs243865C > T polymorphisms and glaucoma risk

	OR	95% CI	P	I ² (%)^a	OR	95% CI	P	I ² (%)^a	OR	95% CI	P	I ² (%)^a	OR	95% CI	P	I ² (%)^a	OR	95% CI	P	I ² (%)^a
rs1799750 1G > 2G	2G vs. 1G				1G/2G vs. 1G/1G				2G/2G vs. 1G/1G				1G/2G +2G/2G vs. 1G/1G				2G/2G vs. 1G/1G +1G/2G
Total	1.14	0.79-1.64	0.49	85.0	0.86	0.52-1.41	0.55	75.7	1.20	0.59-2.43	0.61	83.4	0.99	0.59-1.69	0.98	81.8	1.35	0.83-2.21	0.23	77.2
Type
PACG	1.61	1.07-2.42	0.02	NA	1.70	0.89-3.24	0.11	NA	2.33	1.03-4.83	0.04	NA	1.86	1.03-3.37	0.04	NA	1.69	0.85-3.37	0.14	NA
POAG	137	0.94-2.01	0.11	81.7	1.00	0.51-1.93	0.99	79.7	1.69	0.81-3.50	0.16	80.0	1.24	0.66-2.33	0.50	8.07	1.69	1.01-2.81	0.05	7.54
XFG	0.82	0.59-1.12	0.23	51.6	0.61	0.41-0.91	0.02	0	0.62	0.38-0.99	0.05	0	0.62	0.42-0.90	0.01	0	0.89	0.51-1.56	0.69	5.17
Design
Heal-B	1.87	1.34-2.61	<0.01	NA	1.93	1.14-3.26	0.02	NA	2.90	1.54-5.49	<0.01	NA	2.23	1.37-3.61	<0.01	NA	2.04	1.15-3.61	0.02	NA
Hosp-B	0.98	0.69-1.38	0.91	79.4	0.67	0.51-0.88	<0.01	0	0.91	0.44-1.90	0.82	80.4	0.81	0.63-1.04	0.10	36.1	1.18	0.65-2.16	0.58	81.7
rs243865 C > T	T vs. C				CT vs. CC				TT vs. CC				CT + TT vs. CC				TT vs. CC + CT
Total	0.78	0.82-1.17	0.79	0	0.91	0.72-1.15	0.43	3.4	1.14	0.57-2.28	0.71	56.3	0.94	0.75-1.17	0.55	0	1.19	0.54-.2.62	0.66	67.4
Type
POAG	95	0.79-1.15	0.62	0	0.86	0.67-1.10	0.23	0	1.14	0.55-2.35	0.73	56.8	0.89	0.71-1.13	0.35	0	1.21	0.55-1.65	0.64	64.5

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