- Research article
- Open Access
- Open Peer Review
Prevalence of refractive errors in Tibetan adolescents
© The Author(s). 2018
- Received: 4 December 2017
- Accepted: 27 April 2018
- Published: 11 May 2018
The prevalence of adolescent eye disease in remote areas of the Qinghai-Tibet Plateau has rarely been reported. To understand the prevalence of common eye diseases in Tibet, we performed ocular-disease screening on students from primary and secondary schools in Tibet, and compared the prevalence to that in the Central China Plain (referred to here as the “plains area”).
The refractive status of students was evaluated with a Spot™ vision screener. The test was conducted three or fewer times for both eyes of each student and results with best correction were recorded.
A total of 3246 students from primary and secondary schools in the Tibet Naidong district were screened, yielding a refractive error rate of 28.51%, which was significantly lower than that of the plains group (28.51% vs. 56.92%, p < 0.001). In both groups, the prevalence of refractive errors among females was higher than that among males.
We found that Tibetan adolescents had a lower prevalence of refractive errors than did adolescents in the plains area, which may be related to less intensive schooling and greater exposure to sunlight.
- Refractive errors
- Abnormal rate
In recent years, with the increasing educational pressure on adolescents, the incidence of eye disorders such as myopia, hyperopia and astigmatism is increasing. These common conditions can cause many inconveniences for people. Visual impairment at birth or during childhood can affect learning, communication, employment, health and quality of life, and the effects are often life-long . According to a survey by Pi et al. , 20% of individuals with visual impairment, worldwide, are children. With the increasing prevalence of visual impairment among young people, more attention is being paid to it. In fact, it is a priority of the World Health Organization’s VISION 2020 program to control visual impairment and blindness in children .
Tibet is located in the southwest of China’s Qinghai-Tibet plateau. It is characterized by its high elevation (an average of > 3500 m), low air pressure and large climatic differences. There are great differences between Tibet and China’s inland cities in regional environment and eating habits. It is known that living at altitudes above 3000 m has effects on the human body [4, 5]. Accordingly, congenital heart disease, high blood pressure and other diseases in Tibet have high incidence and regional characteristics.
In the Tibetan plateau region, the incidence of eye diseases in adolescents also showed certain geographical characteristics. We found that in China, people in the plains pay more attention to the development of visual impairment than do people in Tibet and other plateau areas. Therefore, we conducted a screening study to understand the ocular health status of school-age children living on the Tibetan plateau.
A total of 3248 students in Tibet were enrolled in the screening. The students were from 7 primary schools and 1 secondary school in Naidong district, which averages about 3500 m above sea level. The participants in the Tibetan region are referred to as the “plateau group”.
We have included ocular screening data from 11,102 students from Tianjin Dagang as a control (“plains”) group. The average elevation of the Tianjin Dagang area is 6 m.
Detection of ocular abnormalities
Diagnostic criteria for various eye disorders
The crude rates of myopia, hypermetropia and anisometropia were determined using direct standardization (both age and sex). Means ± standard deviation (SD), frequencies, and percentages were used to summarize the characteristics of the research subjects. The rate of each type of abnormality was compared between the two groups, using chi-square tests. The Cochran–Armitage test for trend was used to determine whether there was an association between participant age and the prevalence of disorders. All statistical analyses were performed using IBM SPSS Statistics software (version 22.0). P-values less than 0.05 were considered statistically significant.
Age (average ± SD, year)
The screening results were abnormal for 926 students in the plateau group (28.51% of the total). Compared with the anomaly rate of 56.93% in the plains group, the anomaly rate of the plateau group was significantly lower. Analysis of the two groups by sex showed that the anomaly rate for males in the plateau group was significantly lower than that in the plains group; the same was true for females. Finally, both groups had higher rates of anomalies among females than males.
Ocular abnormalities in the two groups
Type of disorder
Plateau group (n,%)
Plains group (n,%)
p < 0.001
p < 0.001
p < 0.001
p < 0.001
P = 0.221
p < 0.001
It is known that living at altitudes above 3000 m has biological effects on humans [4, 5]. The unique plateau environment comprises low air pressure, reduced oxygen, dryness, cold weather, sunshine and exposure time, intense solar infrared light, intense ultra-violet radiation, and long winters, which all have effects on the human body, in general, and on the eyes in particular [6, 7]. Because Tibet is located on the high-altitude Qinghai-Tibet plateau, the environment could be expected to affect the ocular health of people living there, but not much is known about the rates of eye diseases in the plateau region. We therefore conducted this study and used the data from the plains group to study the characteristics of common refractive errors in Tibet by comparing results between the two groups.
We found that myopia was the most prevalent abnormality in the plateau group, as well as in the plains group. In recent years, the incidence of myopia has gradually increased, attracting more attention from researchers and the public. Myopia has a serious impact on society, including on education and the economy, and it also can cause great inconvenience for patients . Previous studies have shown that the prevalence of myopia in various regions of the world varies widely. In Western populations, myopia (nearsightedness) is found in one out of every three individuals [9–11]; in contrast, in selected regions of Asia, its prevalence is as high as 80% [12, 13]. High school is the high time of myopia. During this period, students can have a great deal of schoolwork to do, and previous researchers have shown that the intensity of studying closely relates to the incidence of myopia, so that could account for the high incidence of myopia in adolescents. Studies have also shown that, within a certain range, the longer the exposure to outdoor sunlight, the lower the incidence of myopia . In the plateau region,, there are more hours of sunlight, and, because of the lower pressure on students, time for outdoor activities can be greater. Therefore, the students in the plateau group may be exposed to longer periods of sunshine, which could explain their lower prevalence of myopia.
Despite the high altitude of the plateau region, in the present study, the prevalence of eye disorders in Tibet was significantly lower than that in Tianjin Dagang. We hypothesize that this may be because the Tibetan children have less homework and lower scholastic pressure. The level of education in Tibet is lagging behind that in Tianjin, and students would have fewer hours in school and more time outdoors. Previous studies have shown that advising children to go outdoors at rest (for about 80 min a day) can decrease their myopia by half in 1 year . Although there is no proven connection between refractive errors and educational methods or the environment, a relaxed lifestyle is likely beneficial to ocular health. In both the plateau and plains groups, the prevalence of refractive errors was higher for females than males, which may be due to girls performing fewer outdoor activities than boys do.
There are some limitations to our study. Due to logistical constraints, we could only test for common refractive errors and did not obtain information on other eye disorders or diseases. In additional, when screening for myopia, we did not have specialized inspection shadow diopter examination or clinical diagnoses. Thus we may be overestimating the prevalence of myopia, so that the rate reported here should be referred to as a “suspected myopia” rate. Finally, we did not record the children’s family relationships, so we do not know if there were cases of multiple children from the same family. Children in the same family share many lifestyle factors, which could have biased the results of the present study .
In this high-altitude region in Tibet, the prevalence of refractive errors in adolescents was significantly lower than that in adolescents living in the plains region, which may be related to easier schooling and more exposure to sunlight.
We thank all of the students for participating in the study.
This project was supported by the National Key Research and Development Program of China (No. 2016YFC1000307-6), the Natural Science Foundation of Tibet Autonomous Region (Medical support), National Science and Technology Basic Work(2014FY130100) and the National Infrastructure of Chinese Genetic Resources (YCZYPT01).
Availability of data and materials
The datasets used and/or analysed during the current study available from the corresponding author on reasonable request.
XHQ performed the data analysis and participated in article writing. BL was responsible for the data collection and drafting the manuscript. JW, NW and XLQ revised the manuscript and gave final approval. XL, JL and YZ also collected data. NH, YN and GD processed the data. XM participated in both designing the experiment and analyzing the data. BW guided the experimental design and conducted the study. All authors have read and approved the manuscript.
Ethics approval and consent to participate
The study protocol was performed in accordance with the tenets of the Declaration of Helsinki and was approved by the Tianjin Medical University Eye Hospital’s ethics committee. We obtained informed consent from all participants, including the guardians of children less than 16 years of age.
The authors declare that they have no competing interests.
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- Brown MM, Brown GC, Sharma S, Busbee B. Quality of life associated with visual loss: a time tradeoff utility analysis comparison with medical health states. Ophthalmology. 2003;110(6):1076–81.View ArticlePubMedGoogle Scholar
- Pi LH, Chen L, Liu Q, Ke N, Fang J, Zhang S, Xiao J, Ye WJ, Xiong Y, Shi H, et al. Prevalence of eye diseases and causes of visual impairment in school-aged children in western China. Journal of epidemiology. 2012;22(1):37–44.View ArticlePubMedPubMed CentralGoogle Scholar
- Gilbert C, Foster A. Childhood blindness in the context of VISION 2020--the right to sight. Bull World Health Organ. 2001;79(3):227–32.PubMedPubMed CentralGoogle Scholar
- Wang GQ, Bai ZX, Shi J, Luo S, Chang HF, Sai XY. Prevalence and risk factors for eye diseases, blindness, and low vision in Lhasa, Tibet. International journal of ophthalmology. 2013;6(2):237–41.PubMedPubMed CentralGoogle Scholar
- Gallagher RP, Lee TK. Adverse effects of ultraviolet radiation: a brief review. Prog Biophys Mol Biol. 2006;92(1):119–31.View ArticlePubMedGoogle Scholar
- Guo B, Lu P, Chen X, Zhang W, Chen R. Prevalence of dry eye disease in Mongolians at high altitude in China: the Henan eye study. Ophthalmic Epidemiol. 2010;17(4):234–41.View ArticlePubMedGoogle Scholar
- Bali J, Chaudhary KP, Thakur R. High altitude and the eye: a case controlled study in clinical ocular anthropometry of changes in the eye. High altitude medicine & biology. 2005;6(4):327–38.View ArticleGoogle Scholar
- Saw SM, Katz J, Schein OD, Chew SJ, Chan TK. Epidemiology of myopia. Epidemiol Rev. 1996;18(2):175–87.View ArticlePubMedGoogle Scholar
- Kempen JH, Mitchell P, Lee KE, Tielsch JM, Broman AT, Taylor HR, Ikram MK, Congdon NG, O'Colmain BJ. Eye diseases prevalence research G: the prevalence of refractive errors among adults in the United States, Western Europe, and Australia. Arch Ophthalmol. 2004;122(4):495–505.View ArticlePubMedGoogle Scholar
- Lee KE, Klein BE, Klein R, Wong TY. Changes in refraction over 10 years in an adult population: the beaver dam eye study. Invest Ophthalmol Vis Sci. 2002;43(8):2566–71.PubMedGoogle Scholar
- Chang PY, Yang CM, Yang CH, Huang JS, Ho TC, Lin CP, Chen MS, Chen LJ, Wang JY. Clinical characteristics and surgical outcomes of pediatric rhegmatogenous retinal detachment in Taiwan. Am J Ophthalmol. 2005;139(6):1067–72.View ArticlePubMedGoogle Scholar
- Shimizu N, Nomura H, Ando F, Niino N, Miyake Y, Shimokata H. Refractive errors and factors associated with myopia in an adult Japanese population. Jpn J Ophthalmol. 2003;47(1):6–12.View ArticlePubMedGoogle Scholar
- Wong TY, Foster PJ, Hee J, Ng TP, Tielsch JM, Chew SJ, Johnson GJ, Seah SK. Prevalence and risk factors for refractive errors in adult Chinese in Singapore. Invest Ophthalmol Vis Sci. 2000;41(9):2486–94.PubMedGoogle Scholar
- Wang Y, Ding H, Stell WK, Liu L, Li S, Liu H, Zhong X. Exposure to sunlight reduces the risk of myopia in rhesus monkeys. PLoS One. 2015;10(6):e0127863.View ArticlePubMedPubMed CentralGoogle Scholar
- Wu PC, Tsai CL, Wu HL, Yang YH, Kuo HK. Outdoor activity during class recess reduces myopia onset and progression in school children. Ophthalmology. 2013;120(5):1080–5.View ArticlePubMedGoogle Scholar