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Table 3 Analyses of Risk Factors for depression among Patients with glaucoma

From: The association between glaucoma and risk of depression: a nationwide population-based cohort study

Predictive variables

Univariate analysis

Multivariable analysis

Unadjusted HR

p-value

Adjusted HR

p-value

(95% CI)

(95% CI)

Age

 30–50

Reference

 

Reference

 

 50–60

1.56(1.23–1.99)

< 0.001

1.39(1.09–1.77)

< 0.001

 60–70

1.31(1.03–1.68)

< 0.05

1.27(1.03–1.58)

< 0.05

  ≥ 70

1.56(1.22–1.99)

< 0.001

1.35(1.06–1.78)

< 0.05

Gender (Male vs. Female)

0.64(0.54–0.76)

< 0.0001

0.71(0.60–0.84)

< 0.0001

Charlson comorbidity index

  < 3

Reference

 

Reference

 

  ≥ 3

1.18(0.94–1.49)

0.15

1.16(0.92–1.47)

0.23

Insurance cost

  < 40,000 NTD

Reference

 

Reference

 

  ≥ 40,000 NTD

0.44(0.32–0.61)

< 0.0001

0.53(0.38–0.75)

< 0.001

Urbanization level

 Urban

Reference

 

Reference

 

 Rural

1.07(0.88–1.30)

0.49

0.97(0.80–1.18)

0.77

Living alone

 No

Reference

 

Reference

 

 Yes

1.36(1.06–1.73)

< 0.05

1.34(1.03–1.73)

< 0.05

Substance abuse

 No

Reference

 

Reference

 

 Yes

1.62(1.08–2.87)

< 0.05

1.51(1.02–2.57)

< 0.05

Number of glaucoma medications

  < 3

Reference

 

Reference

 

  ≥ 3

0.88(0.70–1.11)

0.28

0.83(0.60–1.16)

0.28

Types of glaucoma medications

 Sympathomimetics (Yes vs. No)

0.91(0.76–1.08)

0.28

0.68(0.36–1.28)

0.23

 Pilocarpine (Yes vs. No)

1.52(0.92–2.30)

0.11

1.57(0.93–2.10)

0.10

 Carbonic anhydrase inhibitors (Yes vs. No)

0.82(0.67–1.01)

0.07

0.89(0.69–1.14)

0.35

 β-blocker (Yes vs. No)

1.00(0.85–1.19)

0.97

1.07(0.88–1.29)

0.51

 Prostaglandin analogs (Yes vs. No)

0.94(0.79–1.14)

0.54

1.40(0.74–2.68)

0.31

  1. NTD indicates New Taiwan Dollar, HR indicates hazard ratio, CI indicates confidence interval, In the multivariable analysis, all the other variables in the Table are included for adjustment