- Case report
- Open Access
Unilateral visual impairment in a patient undergoing chemotherapy: a case report and clinical findings
BMC Ophthalmology volume 19, Article number: 236 (2019)
Visual impairment occurred as an infrequent form of chemotherapeutic toxicity and was often underestimated despite of several reports. We described a case of acute unilateral visual impairment after one cycle of intravenous chemotherapy of a normal dose, aiming at raising attention to chemotherapy-induced ocular toxicity.
The patient developed a progressive vision loss in the right eye during the chemotherapy. After one cycle of intravenous chemotherapy, her visual acuity decreased by 0.6 in the right eye (VOD = 0.4) compared to the previous value of 1.0 (VOD = 1.0). No evidence of ocular infiltration was observed from the cerebral magnetic resonance imaging (MRI). During her follow-up period, we documented the ophthalmologic examinations including visual acuity, visual field (VF), visual evoked potential (VEP), electroretinogram (ERG), fundus photograph (FP), fundus fluorescein angiography (FFA) and optical coherence tomography (OCT). Ophthalmoscope examination and fundus photograph showed optic disc edema, fuzzy boundary and linear hemorrhages in her right eye. Fundus fluorescein angiography (FFA) revealed capillary underdevelopment at the nasal and superior temporal area of the optic disc in the early phase and capillary fluorescein leakage in the late phase. The result of VEP test suggested the impaired function of the optic nerve. Thus, a diagnosis of nonarteritic anterior ischemic optic neuropathy (NAION) was made by the ophthalmologist according to these results. The patient was prescribed prednisone combined with neuroprotective drugs, which did not work. After the cessation of chemotherapy, her impaired vision gradually recovered.
This is the first reported case of acute visual impairment in a patient who underwent chemotherapy of a normal dose. It is indicated that while receiving benefits from chemotherapy, cancer patients simultaneously suffer from the risk of vision loss.
Patients with malignancies benefit from the advancement in chemotherapeutic treatments, but chemotherapeutic agents also present a wide spectrum of toxic effects in parallel. In recent years, it has been reported that chemotherapy could induce irreversible or reversible visual loss due to an infrequent form of chemotherapeutic toxicity. For instance, a case that a male patient who had lung cancer suffered from acute unilateral blindness after 5 cycles of cisplatin/gemcitabine (cisplatin 80 mg/m2, gemcitabine 1250 mg/m2) was reported in a study . Visual complications including visual loss are very likely to emerge after patients receive chemotherapy, which are imperative to consult at the ophthalmology department.
A 48-year-old woman developed tinnitus and enlarged cervical lymph nodes. Nasopharyngoscopy examination and biopsy confirmed the diagnosis of nasopharyngeal squamous cell carcinoma, thus, she received the anti-tumor therapy of a combination of docetaxel, cisplatin and fluorouracil (TPF: docetaxel used on the first day at 75 mg/m2, cisplatin used on the first and second day at 75 mg/m2 and fluorouracil used from the first day to fifth day at 500 mg/m2) which was repeated every four weeks. The patient complained of visual loss in the right eye two weeks after the first cycle of chemotherapy, and she received the second cycle of chemotherapy as planned.
One week later, she visited an ophthalmologist for the first time because of progressing vision loss, and visual acuity was tested (VOD: visio oculus dexter, for the right eye; VOS: visio oculus sinistra, for the left eye). Her visual acuity had a decrease of 0.6 in the right eye (VOD = 0.4) compared to the original value (VOD = 1.0), and the relative afferent pupillary defect (RAPD) was tested for the right eye. She had a history of high myopia and amblyopia in her left eye evidenced by the low visual acuity (VOS=CF/25 cm, meaning that she could only count fingers at the distance of 25 cm ahead). The current vision impairment in her right eye therefore seriously affected her quality of life. Ophthalmoscope examination and fundus photograph showed optic disc edema, fuzzy boundary and linear hemorrhages in the right eye (Fig. 1a). Typical fundus changes of high myopia were observed in the left eye, such as atrophic arc around optic disc, fuchs spot and tigroid fundus (Fig. 1b). The cerebral magnetic resonance imaging (MRI) provided evidence of no tumor involvement in orbits and central visual pathways (Fig. 1c and d). The long optic axis of the left eye is a typical feature of high myopia eyeball (Fig. 1d). The patient received neurotrophic drug treatments including mecobalamine and citicoline. Three weeks later, the visual acuity in the right eye decreased to 0.3 and the signs of optic disc mentioned above also existed.
About one week after the third cycle of chemotherapy, she visited the ophthalmologist for the third time. The VOD was determined to be 0.3. The optic disc edema subsided, the upper part of the optic disc became gray and residual retinal hemorrhage was located on the inferior rim. Macular pucker, depigmented macules and hard exudate were observed in the macular area (Fig. 2a). The optic disc optical coherence tomography (OCT) of the right eye showed that the thickness from the internal limiting membrane to the retinal pigment epithelium (ILM-RPE) at the superior side and nasal side was thinner than that in normal eyes (Fig. 2b). Visual field (VF) examination of the right eye indicated severe visual field defects (Fig. 2c). Fundus fluorescein angiography (FFA) as the most important assistant examination revealed an early phase capillary underdevelopment at the nasal and superior temporal area of the optic disc and a late phase capillary fluorescein leakage (Fig. 2d-f). Thus, a diagnosis of NAION was made for the right eye, and gradually reduced high-dose oral prednisone along with neuroprotective drugs were used for treatment. Meanwhile, retrobulbar injection of compound betamethasone (1 ml) combined with eye drops of ocular hypotensive agents were given to the right eye.
One month after finishing three cycles of induction chemotherapy, concomitant intravenous antitumor therapy with radiotherapy was started. Due to the suspicious ocular toxicities of cisplatin, Nimotuzumab, a targeted agent, was recommended as an alternative treatment. The patient made the fourth visit to the ophthalmologist, and the VOD of the right eye was determined to be 0.4. The optic disc edema subsided with clear boundary, but the color of the optic disc was still gray (Fig. 3a). OCT showed the secondary macular epiretinal membrane (Fig. 3b). The VF improved obviously compared with the image three weeks ago, which means the function of the optic nerve had been partially repaired (Fig. 3c). The ERG results of the right eye showed that the amplitudes of a-type and b-type wave, as well as P1-type wave were almost normal, suggesting the normal function of the retina (Fig. 3d). The incubation period of P100-type wave in P-VEP test was lengthened, indicating that the function of optic nerve was partially impaired (Fig. 3e).
After finishing radiotherapy, the patient had not been treated with chemotherapy for 3 months. She made her follow-up visit at the ophthalmic clinic and the VOD improved to be 0.5. Moreover, the color of the optic disc was not as gray as before while the macular epiretinal membrane still existed (Fig. 4a and b). The amplitude and incubation periods of P2-type wave from the right eye were almost normal in F-VEP-1HZ test, which signified that the function of the optic nerve had been mostly repaired (Fig. 4c). About 7.5 months after chemotherapy, the patient’s visual acuity remained at VOD 0.5. The VF of her right eye improved dramatically (Fig. 4d). The results of ophthalmologic examinations during her follow-up period are presented in Table 1.
Discussion and conclusions
The neck mass constitutes the most common presenting symptom of nasopharyngeal carcinoma (NPC) . Impaired vision as the initial presentation of NPC caused by the involvement of the optic nerve was rarely reported. As a treatment of NPC, neoadjuvant chemotherapy was currently reported to effectively reduce local-regional recurrences and distant metastases . Fluorouracil and cisplatin are commonly used with major toxicities including myelo-suppression and vomiting. Ocular complications as rare toxicities have not been widely recognized yet and are difficult to be detected. Owing to the improvement in anti-cancer therapies, NPC manifests a favorable prognosis, which helps patients to live a longer life. In addition, healthy eyes and good vision represent an important part of life quality. Therefore, we reported a case aiming at raising the attention to chemotherapy-induced ocular toxicity in the treatment of NPC.
Due to a sharp decrease of visual acuity, the patient was suggested to consult in an ophthalmology clinic for etiological diagnosis and potential therapy. The diagnoses of glaucoma, cataracts, macular degeneration and other eye diseases were excluded; the right optic disk edema was observed by funduscopic examination; and a diagnosis of NAION was made with etiology unknown. NAION is the most common cause of acute visual loss in people aged over 50, resulting from non-inflammatory small vessel ischemic damage to the anterior portion of the optic nerve. However, the cause and pathogenesis of this disorder remain unclear [4, 5]. Neuroprotective drugs or agents acting on the disc edema are often included in the treatment of NAION, but currently none of the therapy has yet been proved to be effective . Given the temporal relationship between chemotherapy and vision loss of the patient, we suspected that the onset of NAION might be attributed to the intravenous chemotherapy. Because of a combination of drugs, it is difficult to identify a specific agent accounting for the followed vision loss. Since the toxic effect on the retinal or optic nerve might cause irreversible vision loss, the early detection of ocular toxicity and the opportune cessation of anti-cancer therapy are necessary. However, sometimes a trade-off between the risk of permanent visual damage and the effectiveness of anti-cancer therapy may emerge.
Vision loss attributed to cisplatin, docetaxel and fluorine has been reported in several previous studies. Cisplatin-associated retinal toxicity including blurred vision, color vision defects, and electroretinographic (ERG) changes was dose-dependent or unique to high doses. There was a case that a patient with lung cancer who received five cycles of cisplatin/gemcitabine treatment for lung cancer was admitted to the emergency room unfortunately and complained of acute blindness in his left eye. His fundus examination was normal in both eyes, and the MRI of the left optic nerve and orbit did not reveal any relevant findings. A diagnosis of left retrobulbar optic neuritis was made eventually . There was another case that a 55-year-old man planned to receive a 4-day continuous infusion of cisplatin at a dose of 25 mg/m2 daily as part of a chemotherapeutic salvage regimen for non-Hodgkin lymphoma, but received actual dose of 100 mg/m2 daily for 4 days inadvertently. Except for anorexia, nausea and tinnitus, he developed bilateral decreased vision immediately after the treatment. The ERG showed diminished a-wave and missed b-wave . A clinical study of 52 patients determined the prevalence rates of 5-FU-associated ocular abnormalities . The results showed that the most common presentation was tearing (26.9%), followed by blurred vision (11.5%). After receiving 12 courses of intravenous 5-FU for metastatic breast cancer, a 72-year-old woman complained of a sudden visual loss, and her vision started to recover after the discontinuation of anti-cancer agent. A deficiency of dihydropyrimidine dehydrogenase (DPD) was detected and 5-FU was considered to be responsible for the visual loss associated with DPD deficiency . Another female who received monthly intravenous infusion of docetaxel for metastastic breast cancer also complained of blurred vision in both eyes two months later after the treatment. Then docetaxel was replaced by Xeloda, and her vision started to recover .
When patients suddenly develop vision loss while receiving chemotherapy, the possibility of chemotherapy-induced NAION should be considered. Most ophthalmic complications are reversible if recognized in an early phase. Besides, dosage reduction or agent cessation could rescue patients from vision loss. However, if the optic nerve or the retinal was involved, patients might develop irreversible vision loss. Induction chemotherapy plays a crucial role in the treatment of local advanced nasopharyngeal carcinoma, and presented here was one case of severe visual impairment induced by chemotherapy. Therefore, it is indicated that cancer patients take the risk of vision loss while benefiting from chemotherapy.
Although it has been reported that intravenous chemotherapy of cisplatin and docetaxel could cause retinal toxicity, this is the first case demonstrating that intravenous administration of chemotherapy (TPF) for NPC could induce NAION and cause irreversible vision loss. This reported case suggests that when patients suddenly develop visual impairment after receiving chemotherapy, the possibility of ophthalmic complications should be considered. In addition, as soon as symptoms are recognized, the patient should be scheduled for further examinations in the ophthalmology clinic, and a cooperation between oncologists and ophthalmologists is necessary for subsequent treatment.
Availability of data and materials
The data supporting the conclusions of this article are included within the article.
Fundus fluorescein angiography
Internal limiting membrane
Magnetic resonance imaging
Nonarteritic anterior ischemic optic neuropathy
Optical coherence tomography
Relative afferent pupillary defect
Visual evoked potential
Visio oculus dexter, for the right eye
Visio oculus sinistra
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Yuan, X., Feng, Y., Li, D. et al. Unilateral visual impairment in a patient undergoing chemotherapy: a case report and clinical findings. BMC Ophthalmol 19, 236 (2019). https://doi.org/10.1186/s12886-019-1246-3
- Vision loss
- Nonarteritic anterior ischemic optic neuropathy