Table 1 Basic characteristics of enrolled subjects

Number of subjects or patients

106

49

57

Number of eyes

212

98

114

Age (years)

52.8 ± 13.5

51.9 ± 13.2

53.6 ± 13.7

0.200^*

Sex (M:F)

40:66

21:28

19:38

0.159†

Ocular Surface Disease Index (OSDI)

43.6 ± 23.6

38.5 ± 24.9

47.8 ± 21.8

0.029^*

Schirmer (mm)

10.1 ± 6.2

11.6 ± 6.5

8.8 ± 4.4

0.002^*

Cornea stain (Oxford)

0.8 ± 0.8

0.3 ± 0.6

1.2 ± 0.8

0.000^*

tBUT_BE (sec)

12.2 ± 9.2

14.5 ± 9.9

10.3 ± 8.2

0.000^*

tBUTs (sec)

8.8 ± 5.3

10.2 ± 5.7

7.5 ± 4.7

0.003^*

BTT (sec)

13.5 ± 17.1

18.1 ± 22.8

9.6 ± 8.1

0.024^*

BTT-tBUT_BE (sec)

1.3 ± 17.0

3.6 ± 22.9

−0.7 ± 9.1

0.534^*

BTT- tBUTs (sec)

4.8 ± 16.8

7.9 ± 23.3

2.1 ± 6.8

0.626^*