Skip to main content
  • Research article
  • Open access
  • Published:

Microvascular comparison in younger and older patients with retinal vein occlusion analyzed by OCT angiography



To compare changes in retinal microvasculature of young and elderly patients with retinal vein occlusion (RVO) after anti-VEGF treatment.


RVO patients who underwent anti-VEGF treatment were retrospectively reviewed and categorized into two groups based on age. The OCT angiography images were obtained during each visit. Best corrected visual acuity (BCVA), vessel density (VD) and foveal avascular zone (FAZ) were measured and compared between the two groups. Vision improvements and retinal microvasculature changes were also correlated.


Twenty patients with 20 eyes were enrolled in the younger group and 46 patients with 46 eyes were enrolled in the older group. Younger patients demonstrated better BCVA, higher VD and smaller FAZ than older patients at 12 months after the first anti-VEGF treatment. The improvement of VD was observed only in the younger group. A positive correlation between vision improvement and VD increase was noted.


Young patients with RVO can achieve rapid rehabilitation of deep retinal vasculature which lead to a better visual outcome.

Peer Review reports


Retinal vein occlusion is one of the most common retinal vascular diseases influencing approximately 16 million patients worldwide [1]. It usually occurs in elder people, and the predisposing factors include hypertension, hyperglycemia, hyperlipidemia, smoking, and alcohol consumption. Patients often present with venous tortuosity, venous distention, and retinal hemorrhage. Recurrent macular edema, retinal ischemia, and neovascularization are the major reasons for vision loss. The pathological changes of RVO can persist for several months or even years. As the pace of daily life and workplace expectations have accelerated, more young people are suffering from RVO than previous decades. Compared with elderly patients, the risk factors of RVO in young patients is untraditional, though it may be correlated with inflammation [2].

Optical coherence tomography angiography (OCTA), a new technology for detecting retinal microvascular architecture, displays high-resolution images of retina and choroid in separated layers. Recently, an upgraded OCTA software program with a projection artifact removal (PAR) function has been applied in clinical settings [3]. With this advanced technique, the deep capillary structure can be clearly captured and accurately measured, including foveal avascular zone (FAZ) area, vessel density (VD), vessel length density, and size of non-perfusion area [4]. In RVO patients, OCTA can be used to track the change of retinal microvasculature and assess the rehabilitation of blood flow. In this study, we aimed to evaluate the impact of aging on the retinal capillaries reconstruction using OCTA, as well as the correlation of these changes with visual outcomes in patients with RVO.


Patients diagnosed with RVO from September 2017 to October 2019 were enrolled in a retrospective study at Eye Center, Second Affiliated Hospital of Zhejiang University. The Institutional Review Board of the Second Affiliated Hospital of Zhejiang University (No.2019 − 406) approved the study. The study was performed in accordance with the tenets of the Declaration of Helsinki and compliant with the Health Insurance Portability and Accountability Act of 1996. The need for written informed consent was waived by the Institutional Review Board of the Second Affiliated Hospital of Zhejiang University (No.2019 − 406) because of the retrospective design and the use of de-identified patient data.

Patients of macular involved RVO, either central RVO (CRVO), or branch RVO (BRVO), with at least 12-month follow-up and OCTA obtained in each visit were selected. The OCTA images were acquired by AngioVue OCTA system (version 2018.0.01.14, OptovueRTVue XR 100; AVANTI, Inc). Macular angiogram was detected by a 3 × 3 mm scan centered on the fovea. This instrument uses a split-spectrum amplitude decorrelation angiography (SSADA) software algorithm, acquiring 70,000 A-scans/s to compose OCT-A volumes consisting of 304 × 304 A-scans with two consecutive B-scans captured at each fixed position. Retinal layer segmentation was set as reported previously [5]. Manual correction of B-scans were performed if any layer segmentation errors were identified. The projection artifact in the deep capillary plexus (DCP) was automatically eliminated by the AngioVue software (version 2018.0.01.14). Parameters including whole 3 × 3 mm image and parafovea VD of the superficial capillary plexus (SCP) and DCP, size and perimeter of FAZ, as well as central retinal thickness (CRT) were recorded for all subjects.

The exclusion criteria include previous retinal surgery, ocular trauma, coexistence of other retina disorders such as diabetic retinopathy, pathologic myopia or age-related macular degeneration. Eyes that could not be assessed by OCTA due to media opacity, significant eye movements, or segmentation failure arising from severe macular edema were also excluded. Patients were categorized into younger group (50 years or younger at RVO onset) and older group (more than 50 years at RVO onset). All patients underwent a comprehensive routine ophthalmic examination including best-corrected visual acuity (BCVA), intraocular pressure (IOP), fundus photography, spectral domain OCT (Spectralis Heidelberg Engineering, Heidelberg, Germany), and/or fundus fluorescein angiography (FFA). Patients were examined for traditional risk factors. Younger patients without traditional risk factors underwent additional laboratory testing for possible etiology, including coagulation function, protein C and protein S, rheumatoid factor, anticardiolipin antibody, lupus anticoagulant, factor V Leiden, lupus anticoagulant, homocysteine, and cryoglobulins.

Intravitreal injections of the anti-VEGF agents (either ranibizumab or conbercept) were used to treat macular edema for RVO. The patients received an initial intravitreal anti-VEGF injection followed by a pro re nata (PRN) regimen with monthly monitoring. Retreatment with anti-VEGF injection was considered if the recurrence of macular edema detected by SD-OCT exceeding 300 μm CRT. Scatter laser photocoagulation was applied for retinal neovascularization and/or nonperfused areas (NPAs) more than 5 disk area (DA) for eyes with BRVO and NPAs more than 10 DA for eyes with CRVO.

SPSS for Windows version 17.0 (SPSS Inc., Chicago, IL) was used for statistical analysis. A P < 0.05 was considered statistically significant. Quantitative variables were presented as mean ± SD or median (interquartile range). Categorical variables were expressed as values and percentages. Vision improvement rate was used to evaluate the degree of vision recovery. Student’s t test, Mann-Whitney test, and Chi-square test were used to compare variables. Pearson’s r was used to summarize the strength of the correlations.


Sixty-six RVO patients with 66 eyes who were followed for at least 12 months were enrolled. Of these patients, 20 were 50 years old and younger (38.3 ± 7.7, range:22–50), and 46 were older than 50 years old (63.0 ± 6.7, range:52–85). There was no significant difference in the distribution of sex or eye laterality. There was a trend toward better BCVA at the initial visit in younger patients than older patients (logMAR 0.63 ± 0.44 vs. 0.81 ± 0.36, P = 0.078). Of these younger patients, one used oral contraceptives, one was diagnosed with ankylosing spondylitis, two had increased homocysteine levels, and one had severe anemia. One young patient had recurrent retinal and brain vascular occlusion, and the coagulation panel sequence result showed coagulation factor XII deficiency. All patients received one intravitreal injection of anti-VEGF as the initial treatment. The mean number of injections in 12 months was 3.2 ± 2.1 (range:1–7) in the younger group and 3.8 ± 2.2 (range:1–9) in the older group (P = 0.320). Scatter laser coagulation was performed in 8 out of 20 eyes in the younger group and in 18 out of 46 eyes in the older group, which was not significantly different (P = 0.947). All general information of patients is summarized in Table 1.

Table 1 Patient characteristics

There were no significant differences in VD of SCP and DCP or size and perimeter of FAZ at the first visit between the two groups (Table 2). Younger patients showed increased macular VD in both superficial and deep retina circulation and smaller FAZ after anti-VEGF treatment (Table 2). Microvascular improvement by anti-VEGF treatment was achieved only in the younger group, with significant difference in the increase of VD in DCP between two groups (Fig. 1; Table 3). By contrast, the FAZ size increased in the older group after treatment (Fig. 1), which can also be observed in the example shown in Fig. 2. A significant improvement of BCVA after treatment was noted in both younger and older group (both P < 0.001). Compared with the older group, the younger group showed more increase of BCVA (P = 0.007) and significantly better vision (P = 0.003) after treatment vision (Table 4). Significant positive correlation between VD increase and vision improvement rate after anti-VEGF treatment was found only in DCP (Table 5).

Table 2 Microvascular parameters measurements before and after VEGF treatment
Fig. 1
figure 1

The comparison of vessel density and fovea avascular zone change after anti-VEGF treatment. VD: vessel density; SCP: superficial capillary plexus; DCP: deep capillary plexus; FAZ: foveal avascular zone. *P < 0.05

Table 3 Comparison of the change of microvascular parameters measurements in younger and older groups
Fig. 2
figure 2

OCTA images of the superficial and deep capillary plexus in a 64-year-old patient (a and b) and a 25-year-old patient (c and d). (A1, A2, A3, A4) The OCTA images of superficial capillary plexus of the 64-year-old patient at baseline, 1 month, 3 months and 12 months after the first anti-VEGF injection showing the enlargement of FAZ and disappearance of a branch retina capillary (yellow asterisk). (B1, B2, B3, B4) The OCTA images of deep capillary plexus of the 64-year-old patient at baseline, 1 month, 3 months and 12 months after the first anti-VEGF injection presenting the reconstruction of some retinal vasculature (red arrows) and diving of the superficial retina vessels into the deep layer due to retina atrophy (blue arrow). (C1, C2, C3, C4) The OCTA images of superficial capillary plexus of the 25-year-old patient at baseline, 1 month, 3 months and 12 months after the first anti-VEGF injection showing decrease of vascular tortuosity around fovea. (D1, D2, D3, D4) The OCTA images of deep capillary plexus of the 25-year-old patient at baseline, 1 month, 3 months and 12 months after the first anti-VEGF injection presenting the reconstruction of retinal vasculature (red arrows)

Table 4 Vision changes after treatment
Table 5 The correlation between microvasculature parameters change and vision improvement rate all patients


RVO prevalence increases with age, probably due to increased atherosclerosis in elderly patients [6]. The Virchow triad of hypercoagulability, endothelial injury, and stasis of blood flow plays a key role in the process of thrombogenesis in RVO [6]. Atherosclerotic diseases such as hypertension, dyslipidemia, and diabetes are important contributors to thrombogenesis and occur more frequently with aging [6]. However, the pathogenesis and clinical progress of RVO in young patients may be different from in elderly patients [2]. RVO in young patients is closely linked to ocular or systemic diseases such as glaucoma, thrombophilia, autoimmune disease, and oral contraceptive use [2, 6]. It is thought that increased IOP leads to stasis of the retinal vein blood flow at the level of the lamina cribosa, damaging the venous endothelium and predisposing it to thrombosis [7]. In our study, 20 % of young patients had glaucoma, 30 % had traditional risk factors, and 30 % had other systemic disease. No contributing factor was identified in the remaining young patients.

The main vision-threatening complications of RVO include macular edema, retina neovascularization, neovascular glaucoma, and vitreous hemorrhage. Ischemic RVO usually has a poor visual prognosis than non-ischemic one [8]. Previous studies reported better baseline and final visual acuity in younger patients than in older patients with CRVO [2, 6]. Although the initial vision was better in the younger group than the older group in our study, the difference was not statistically significant (P = 0.078). However, younger patients had significantly better final vision at 12 months after the first anti-VEGF treatment than older patients. The ocular condition, such as lens opacity, might contribute to this difference. Therefore, we used vision improvement rate as an index in order to avoid the influence caused by age. Even so, younger patients showed better visual improvements compared with older patients.

OCTA enables noninvasive visualization of retinal vasculature and precise assessment of vascular changes at the capillary level [3]. Unlike FFA showing leaking and staining of the lesions, OCTA can capture subtle changes of microvasculature, including neovascular fronds, microaneurysms, non-perfusion area, and other microvascular abnormalities [3, 9]. Additionally, OCTA shows the microvascular changes in both the SCP and DCP and can be used to conduct depth-resolved studies of microcirculation [3, 9]. Shahlaee et al. have reported a negative correlation between age and retinal vascular density in a healthy population [10]. Wakabayashi et al. have reported that eyes with CRVO and BRVO had lower VD in the superficial and deep vascular layers compared to the fellow eye and normal eyes [11].

High intraocular levels of VEGF are thought to contribute to the development of macular edema and progression of ischemia in RVO [12, 13]. Long-term therapy of anti-VEGF injection has been reported to improve, or at least preserve, retinal perfusion in eyes with RVO [14,15,16]. However, Sellam et al. reported a slight decrease in VD in SCP after anti-VEGF injection in patients with RVO [17]. Spaide showed that anti-VEGF treatment did not change the VD in either superficial or deep capillary plexus in eyes with RVO [18]. In this study, the older group had lower VD than the younger group at baseline, but the difference did not reach the level of significance. The anti-VEGF injections had no significant effect on the VD in the older group at the 12-month follow-up compared with the initial visit. The FAZ size was significantly increased in the older group during the 12-month follow-up. However, there was significantly increased VD in both SCP and DCP in the younger group during the course of follow-up. Younger patients had higher VD in both SCP and DCP, as well as smaller FAZ than the older ones at the 12th month after the first anti-VEGF treatment. The results of studies reporting the effects of anti-VEGF therapy on FAZ area are conflicting in retina vascular disease. Ghasemi Falavarjani et al. reported no statistical difference in FAZ size in the short-term after a single intravitreal anti-VEGF injection in patients with RVO and diabetic macular edema (DME) [19]. Others found no change in FAZ area at 12-month after anti-VEGF treatment in DME patients [20] and RVO patinets [14]. Gill et al. observed a significant FAZ reduction over time after anti-VEGF in DME patients [21]. However, no study above analyzed the impact of anti-VEGF agents on FAZ based on the age of patients. In contrast, we observed enlargement of FAZ during follow-up after treatment in older patients, which is thought to be caused by failure of regeneration of retina microvasculature in this group of patients.

Visual prognosis of RVO usually depends on the initial visual acuity, the extent and the localization of the occlusion, and the retinal perfusion, especially in the macular area [6, 22, 23]. Several studies have shown that final vision was correlated with VD in both the SCP and DCP, and the most significant predictor was vascular perfusion in the DCP [11, 19, 24, 25]. Consistent with previous studies, our study showed a significant correlation between vision improvement and changes in the VD of DCP. Rapid rehabilitation of blood vessels indicated better visual improvements. As previously reported, the DCP is comprised of capillaries with a vortex configuration and drains into large superficial veins [26, 27]. The DCP contains capillaries with higher perfusion pressure and oxygenation, which may be more prominent in protecting the retina from increased venous pressure under RVO. We also compared younger and older patients with regard to changes in retinal perfusion and found that the younger group had more rapid improvement in the VD of DCP. These results indicated that the younger patients with RVO had more rapid rehabilitation of retinal microvasculature after treatment, especially in the DCP, which may lead to better VA improvements. Thus, age is an important factor that may contribute to the retinal blood flow and final vision outcome.

The limitations of this study include its retrospective design, the small number of young patients, and the limited OCTA field of view for analyzing. Loss of follow-up several months after the first anti-VEGF injection due to fast vision recovery of some young patients also generated bias in this study. Some BRVO patients were not enrolled in the study due to lack of macular involvement or loss of follow-up after achieving a satisfied vision, leading to the unnatural rate of BRVO to CRVO patients in this study.


Age might be an important factor in the prognosis of patients with RVO. Younger patients have more rapid and better reconstruction of retinal perfusion than older patients which can contribute to better final vision.

Availability of data and materials

The datasets used and analyzed during the current study are available from the corresponding authors on reasonable request.



Retinal vein occlusion


Best corrected visual acuity


Vessel density


Foveal avascular zone


Optical coherence tomography angiography


projection artifact removal


Central RVO


Branch RVO


Split-spectrum amplitude decorrelation angiography


Deep capillary plexus


Superficial capillary plexus


Central retinal thickness


Intraocular pressure


Fundus fluorescein angiography


Nonperfused areas


Disk area


  1. Rogers S, McIntosh RL, Cheung N, Lim L, Wang JJ, Mitchell P, et al. The prevalence of retinal vein occlusion: pooled data from population studies from the United States, Europe, Asia, and Australia. Ophthalmology. 2010;117(2):313–9 e1.

  2. Rothman AL, Thomas AS, Khan K, Fekrat S. CENTRAL RETINAL VEIN OCCLUSION IN YOUNG INDIVIDUALS: A Comparison of Risk Factors and Clinical Outcomes. Retina. 2019;39(10):1917–24.

    Article  Google Scholar 

  3. Tsai G, Banaee T, Conti FF, Singh RP. Optical Coherence Tomography Angiography in Eyes with Retinal Vein Occlusion. Journal of ophthalmic & vision research. 2018;13(3):315–32.

    Article  Google Scholar 

  4. Zhu T, Ma J, Li J, Dai X, Ye P, Su Z, et al. Multifractal and lacunarity analyses of microvascular morphology in eyes with diabetic retinopathy: A projection artifact resolved optical coherence tomography angiography study. Microcirculation. 2019;26(3):e12519.

    Article  Google Scholar 

  5. Zhu TP, Li EH, Li JY, Dai XZ, Zhang HN, Chen BB, et al. Comparison of Projection-Resolved Optical Coherence Tomography Angiography-Based Metrics for the Early Detection of Retinal Microvascular Impairments in Diabetes Mellitus. Retina. 2020;40(9):1783–92.

    Article  Google Scholar 

  6. Garcia-Horton A, Al-Ani F, Lazo-Langner A. Retinal vein thrombosis: The Internist’s role in the etiologic and therapeutic management. Thromb Res. 2016;148:118–24.

    Article  CAS  Google Scholar 

  7. Marcucci R, Sofi F, Grifoni E, Sodi A, Prisco D. Retinal vein occlusions: a review for the internist. Intern Emerg Med. 2011;6(4):307–14.

    Article  Google Scholar 

  8. Rogers SL, McIntosh RL, Lim L, Mitchell P, Cheung N, Kowalski JW, et al. Natural history of branch retinal vein occlusion: an evidence-based systematic review. Ophthalmology. 2010;117(6):1094–101 e5.

    Article  Google Scholar 

  9. Chung CY, Tang HHY, Li SH, Li KKW. Differential microvascular assessment of retinal vein occlusion with coherence tomography angiography and fluorescein angiography: a blinded comparative study. International ophthalmology. 2018;38(3):1119–28.

    Article  Google Scholar 

  10. Shahlaee A, Samara WA, Hsu J, Say EA, Khan MA, Sridhar J, et al. In Vivo Assessment of Macular Vascular Density in Healthy Human Eyes Using Optical Coherence Tomography Angiography. American journal of ophthalmology. 2016;165:39–46.

    Article  Google Scholar 

  11. Wakabayashi T, Sato T, Hara-Ueno C, Fukushima Y, Sayanagi K, Shiraki N, et al. Retinal Microvasculature and Visual Acuity in Eyes With Branch Retinal Vein Occlusion: Imaging Analysis by Optical Coherence Tomography Angiography. Investigative ophthalmology & visual science. 2017;58(4):2087–94.

    Article  Google Scholar 

  12. Campochiaro PA, Bhisitkul RB, Shapiro H, Rubio RG. Vascular endothelial growth factor promotes progressive retinal nonperfusion in patients with retinal vein occlusion. Ophthalmology. 2013;120(4):795–802.

    Article  Google Scholar 

  13. Sophie R, Hafiz G, Scott AW, Zimmer-Galler I, Nguyen QD, Ying H, et al. Long-term outcomes in ranibizumab-treated patients with retinal vein occlusion; the role of progression of retinal nonperfusion. American journal of ophthalmology. 2013;156(4):693–705.

    Article  CAS  Google Scholar 

  14. Winegarner A, Wakabayashi T, Fukushima Y, Sato T, Hara-Ueno C, Busch C, et al. Changes in Retinal Microvasculature and Visual Acuity After Antivascular Endothelial Growth Factor Therapy in Retinal Vein Occlusion. Investigative ophthalmology & visual science. 2018;59(7):2708–16.

    Article  Google Scholar 

  15. Mir TA, Kherani S, Hafiz G, Scott AW, Zimmer-Galler I, Wenick AS, et al. Changes in Retinal Nonperfusion Associated with Suppression of Vascular Endothelial Growth Factor in Retinal Vein Occlusion. Ophthalmology. 2016;123(3):625–34 e1.

    Article  Google Scholar 

  16. Suzuki N, Hirano Y, Tomiyasu T, Esaki Y, Uemura A, Yasukawa T, et al. Retinal Hemodynamics Seen on Optical Coherence Tomography Angiography Before and After Treatment of Retinal Vein Occlusion. Investigative ophthalmology & visual science. 2016;57(13):5681–7.

    Article  Google Scholar 

  17. Sellam A, Glacet-Bernard A, Coscas F, Miere A, Coscas G, Souied EH. QUALITATIVE AND QUANTITATIVE FOLLOW-UP USING OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY OF RETINAL VEIN OCCLUSION TREATED WITH ANTI-VEGF: Optical Coherence Tomography Angiography Follow-up of Retinal Vein Occlusion. Retina. 2017;37(6):1176–84.

    Article  CAS  Google Scholar 

  18. Spaide RF. Volume-Rendered Optical Coherence Tomography of Retinal Vein Occlusion Pilot Study. American journal of ophthalmology. 2016;165:133–44.

    Article  Google Scholar 

  19. Casselholmde Salles M, Kvanta A, Amren U, Epstein D. Optical Coherence Tomography Angiography in Central Retinal Vein Occlusion: Correlation Between the Foveal Avascular Zone and Visual Acuity. Investigative ophthalmology & visual science. 2016;57(9):OCT242-6.

    Google Scholar 

  20. Conti FF, Song W, Rodrigues EB, Singh RP. Changes in retinal and choriocapillaris density in diabetic patients receiving anti-vascular endothelial growth factor treatment using optical coherence tomography angiography. International journal of retina and vitreous. 2019;5:41.

    Article  Google Scholar 

  21. Gill A, Cole ED, Novais EA, Louzada RN, de Carlo T, Duker JS, et al. Visualization of changes in the foveal avascular zone in both observed and treated diabetic macular edema using optical coherence tomography angiography. International journal of retina and vitreous. 2017;3:19.

    Article  Google Scholar 

  22. Lang GE, Lang SJ. [Retinal Vein Occlusions]. Klinische Monatsblatter fur Augenheilkunde. 2018;235(11):1297–315.

    Article  Google Scholar 

  23. Hayreh SS, Podhajsky PA, Zimmerman MB. Natural history of visual outcome in central retinal vein occlusion. Ophthalmology. 2011;118(1):119–33 e1-2.

    Article  Google Scholar 

  24. Seknazi D, Coscas F, Sellam A, Rouimi F, Coscas G, Souied EH, et al. OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY IN RETINAL VEIN OCCLUSION: Correlations Between Macular Vascular Density, Visual Acuity, and Peripheral Nonperfusion Area on Fluorescein Angiography. Retina. 2018;38(8):1562–70.

    Article  Google Scholar 

  25. Samara WA, Say EA, Khoo CT, Higgins TP, Magrath G, Ferenczy S, et al. Correlation of Foveal Avascular Zone Size with Foveal Morphology in Normal Eyes Using Optical Coherence Tomography Angiography. Retina. 2015;35(11):2188–95.

    Article  Google Scholar 

  26. Bonnin S, Mane V, Couturier A, Julien M, Paques M, Tadayoni R, et al. New Insight into the Macular Deep Vascular Plexus Imaged by Optical Coherence Tomography Angiography. Retina. 2015;35(11):2347–52.

    Article  Google Scholar 

  27. Paques M, Tadayoni R, Sercombe R, Laurent P, Genevois O, Gaudric A, et al. Structural and hemodynamic analysis of the mouse retinal microcirculation. Investigative ophthalmology & visual science. 2003;44(11):4960–7.

    Article  Google Scholar 

Download references


Not applicable.


Research was supported by Zhejiang Natural Science Foundation Project of China (No. LY18H120001), National Natural Youth Science Foundation Project of China (No. 31500795) and Zhejiang University Foundation Project (No. 2020-518052-0054).

Author information

Authors and Affiliations



PPY obtained funding, collected and interpreted the data, drafted the initial manuscript, and revised the manuscript. TPZ collected and interpreted the data, and critical reviewed the manuscript. FZ and MZ interpreted the data, and critical revised the manuscript. XYF and KY conceptualized and designed the study, coordinated and supervised data collection, analyzed the data, critically reviewed and revised the manuscript. All authors read and approved the final manuscript.

Corresponding authors

Correspondence to Xiaoyun Fang or Ke Yao.

Ethics declarations

Ethics approval and consent to participate

The study was approved by the Institutional Review Board of the Second Affiliated Hospital of Zhejiang University (No.2019 − 406) and was conducted in accordance with the Declaration of Helsinki.The need for written informed consent was waived the Institutional Review Board of the Second Affiliated Hospital of Zhejiang University (No.2019 − 406) because of the retrospective design and the use of de-identified patient data.

Consent for publication

Not applicable.

Competing interests

The authors declare they have no competing interest.

Additional information

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit The Creative Commons Public Domain Dedication waiver ( applies to the data made available in this article, unless otherwise stated in a credit line to the data.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Ye, P., Zhu, T., Zheng, F. et al. Microvascular comparison in younger and older patients with retinal vein occlusion analyzed by OCT angiography. BMC Ophthalmol 21, 161 (2021).

Download citation

  • Received:

  • Accepted:

  • Published:

  • DOI: