- Case report
- Open Access
Sub internal limiting membrane hemorrhage followed by bilateral optic disc hemorrhage in Kikuchi-Fujimoto disease: a case report
BMC Ophthalmology volume 21, Article number: 355 (2021)
Kikuchi-Fujimoto disease (KFD) is a necrotizing lymphadenitis, and presents fever of unknown origin and cervical lymphadenopathy. Ocular complications are unusual in KFD. Here we report a case of sub internal limiting membrane (ILM) hemorrhage followed by bilateral optic disc hemorrhage in KFD.
A 16-year-old Japanese man perceived a sudden decrease of right vision 3 days after onset of fever with unknown origin and left cervical lymphadenopathy. At presentation, visual acuity (VA) of right eye was 0.05 in decimal chart (1.30: converted to logarithm of minimum angle of resolution: logMAR). Fundus photograph showed extensive sub-ILM hemorrhage in right eye, and optic disc hemorrhages in both eyes. Fluorescein angiography presented hypo- and hyperfluorescences in optic disc of right eye, and hyperfluorescence in the disc of left eye. To make a definitive diagnosis, cervical lymph node biopsy was performed, and KFD was diagnosed pathologically. Thereafter, fever, headache and the cervical lymphadenopathy disappeared spontaneously. The sub-ILM hemorrhage was drained into the vitreous cavity by neodymium:yttrium-aluminum-garnet laser (Nd: YAG) hyaloidotomy. VA recovered to 1.5 (− 0.18: logMAR VA) in right eye.
Sub-ILM hemorrhage and optic disc hemorrhage are a KFD-related ocular complication.
Kikuchi-Fujimoto disease (KFD) is a rare disease of necrotizing lymphadenitis with a self-limited clinical course of fever and lymphadenopathy [1, 2]. KFD is more prevalent in Asian populations, especially young Asian women [1, 3,4,5]. The pathogenesis of KFD remain unknown , although autoimmunity and various infectious etiologies are recognized as disease-related factors [2, 6,7,8,9,10,11,12]. Ocular complications in KFD are unusual, but anterior uveitis , panuveitis , occlusive retinal vasculitis  and preretinal hemorrhage  have been reported. Here we present a case of KFD developing an extensive sub internal limiting membrane (ILM) hemorrhage in the right eye, followed by optic disc hemorrhages in both eyes.
Approval by the Ethics Committee of National Defense Medical College was waived because the study was a retrospective review of medical records. The Declaration of Helsinki was followed in this case report. Patient consent was obtained for the publication of the contents in this report.
A 16-year-old Japanese man visited a local clinic for a low-grade fever of over 37 °C, left abdominal pain, left cervical lymphadenopathy and rhinorrhea in autumn 2016. As past history, he had been vaccinated against mumps 5 months ago. Although the cause of his symptoms was unknown, acetaminophen (1200 mg three times daily) and Shoseiryuto (Xiao-Qing-Long-Tang; a Kampo medicine, 9 g three times daily) were prescribed for symptomatic treatment. At 11 days after onset (day of initial consultation), he returned to the clinic because of a high fever of around 39 °C. The physician suspected bacterial infections including acute sinusitis, and prescribed levofloxacin (500 mg once daily for 3 days) in addition to previous prescriptions. The symptoms did not improve after 3 days (total 14 days after onset). Therefore, the antibiotic was changed to azithromycin (500 mg once daily for 3 days). On the same day, computed tomography was performed and detected only left submandibular lymphadenopathy (data not shown). Mumps was firstly suspected, and he was observed under symptomatic treatment. After 13 days (total 27 days), he developed a severe headache, mild stiff neck and sudden decrease of visual acuity in the right eye. Based on these clinical features, meningitis of unknown pathogen was suspected, and he was referred to the National Defense Medical College Hospital on the same day.
On admission, the best-corrected visual acuity (BCVA) was 0.05 in decimal chart (1.30: converted to the logarithm of the minimum angle of resolution; logMAR) in the right and 1.5 (− 0.18: logMAR VA) in the left eye. Ophthalmoscopic examination of the right eye showed no inflammatory cells in the anterior chamber and anterior vitreous cavity. Color fundus photograph and spectral-domain optical coherence tomography (SD-OCT) image demonstrated an extensive sub internal limiting membrane (ILM) hemorrhage covering the macula and a blot hemorrhage at the temporal posterior pole (Fig. 1, A and C). On the other hand, there was no abnormal feature in the left eye (Fig. 1, B and D). At 8 days after hospitalization (total 43 days), color fundus images showed new optic disc hemorrhages with swollen optic discs in both eyes (Fig. 2, A and B). Fluorescein angiography (FA) images revealed no delayed filling in retinal circulation and retinal vasculitis in both eyes (Fig. 2, C), and presented mixed findings of hypo- and hyperfluorescence in the optic disc of right eye (Fig. 2, D), and hyperfluorescence in the optic disc of left eye, implying dye poolings (Fig. 2, E).
In blood test data, the count of red blood cell was 5.50 × 106 /μL, and the levels of hemoglobin and hematocrit were 16.1 g/dL and 44.4%, respectively (Supplementary Table 1). The count of white blood cell was 4.90 × 103 /μL, and the percentages for neutrophil and lymphocyte were severally 59.8 and 29.2%. The elevation of soluble interleukin-2 receptor (826 U/mL) suggested non-specific mild systemic inflammation. Furthermore, systemic thrombophilia was indicated by elevated levels of fibrinogen (569 mg/dL) and D-dimer (1.8 μg/mL) as well as low level of protein S (56%).
In cerebrospinal fluid (CSF) tests, CSF pressure (25 cmH2O) and cell count (77 /mm3) were elevated, although protein (53 mg/dL) and glucose (55 mg/dL) levels were almost within normal ranges, suggesting aseptic meningitis (Supplementary Table 2). In addition, immunological examinations of serum and CSF were negative for active viral infections by herpes simplex virus (HSV), varicella zoster virus (VZV), Epstein-Barr (EB) virus and mumps virus. To identify the cause of lymphadenopathy, cervical lymph node biopsy was performed. In the pathological section of the lymph node, many phagocytic histiocytes, including a few “crescentic histiocytes” (blue arrow in Fig. 3) were confirmed in the area with necrosis. Based on the pathological findings, his disease was diagnosed as KFD. Treatment guidelines have not been established for KFD, and observation is the most common approach in management due to the self-limited, benign course of KFD . Therefore, only oral acetaminophen and Shoseiryuto were prescribed to control the fever and headache during the course of treatment.
For ophthalmic diagnostic tests, aqueous humor (AH) was collected to detect pathogens by a comprehensive polymerase chain reaction (PCR) test . The comprehensive PCR test showed negative results for the following infections: human herpesvirus (HHV)-1 to − 8, bacterial 16S ribosomal ribonucleic acid (rRNA), fungus 28S rRNA, syphilis, tuberculosis, toxoplasma and toxocariasis. The remaining serum, CSF and AH samples were used to examine cytokine levels using a multiplex immunoassay beads system (Bio-Plex Human Cytokine 27-plex panel: Bio-Rad, Hercules, CA, USA) (Table 1). The AH levels of granulocyte colony-stimulating factor (G-CSF) and vascular endothelial growth factor (VEGF) were respectively 213.8 pg/mL and 439.1 pg/mL, which were remarkably high compared to zero (mean value, G-CSF) and 132 pg/mL (VEGF) in senile cataract patients as healthy elderly controls . On the other hand, interferon gamma-induced protein 10 (IP-10) level was 10.0 pg/mL, which was excessively low compared to 273 pg/mL (IP-10) in the controls .
The sub-ILM hemorrhage did not disappear spontaneously, and remained on the macula. At 15 days of hospitalization (total 44 days), BCVA of right eye was 0.09 (1.05: logMAR VA). To resolve the sub-ILM hemorrhage that may cause toxic retinal damage in the macula , neodymium-yttrium-aluminum-garnet (Nd:YAG) laser was applied in single shot at 1.2 mJ to the hyaloid face of the dome-shaped ILM. The sub-ILM hemorrhage was successfully drained into the vitreous cavity (Fig. 4, A). Thereafter, secondary vitreous opacity was absorbed naturally. At 13 days after laser treatment, BCVA of right eye recovered to 0.4 (0.40: logMAR VA). Approximately four and a half months after laser treatment (total 182 days), vitreomacular traction (VMT) syndrome was observed (Fig. 4, B and D), but BCVA of right eye was 1.0 (0: logMAR VA). Around 6 months after the laser treatment (total 224 days), the VMT syndrome was resolved spontaneously (Fig. 4, C and E), but slight ILM folds (Fig. 4, E: orange yellow arrowheads) were presented. BCVA of the right eye recovered to 1.5 (− 0.18: logMAR VA).
The patient had no ophthalmologic complications, and did not develop autoimmune diseases including systemic lupus erythematosus (SLE)  during a follow-up period of 3 years.
Discussion and conclusions
In 1972, KFD was first reported in young Japanese females by Kikuchi  and Fujimoto . KFD is known to be a relatively rare disease characterized by subacute necrotizing lymphadenopathy [1, 2]. The disease is benign and self-limited with mild fever, and occasionally associated with other systemic disorders such as SLE [1, 3,4,5]. KFD affects predominantly Asian populations, especially young Asian women [1, 3,4,5]. The etiology of KFD remains unknown , although numerous viruses are suspected to be possible pathogenic agents of KFD, including HSV, VZV, HHV-6, − 7, − 8, cytomegalovirus, EB virus, parvovirus B19, paramyxovirus, parainfluenza virus, rubella, hepatitis B virus, human immunodeficiency virus, human T-lymphotropic virus type 1 and dengue virus . Previous studies suggested the potential association of KFD with systemic autoimmune disorders including arthritis , adult Still’s disease , polymyositis , interstitial lung disease , scleroderma , thyroiditis  and drug hypersensitivity . Therefore, the diversity of the above-mentioned diseases may complicate the ensuing course. On the other hand, ocular complications in KFD are unusual, and only a few case reports have described anterior uveitis , panuveitis , occlusive retinal vasculitis , preretinal hemorrhage  and papillary edema . Here we report a patient with KFD who developed sub-ILM hemorrhage in the right eye followed by bilateral optic disc hemorrhages.
In this study, bilateral optic neuritis (ON) was simultaneously occurred. ON is typically idiopathic or demyelinating, and is characterized by unilateral, subacute, painful loss of vision that is not associated with any systemic or other neurological symptoms . Demyelinating ON is associated with multiple sclerosis (MS) or neuromyelitis optica (NMO) , although secondary ON induced by infectious and inflammatory etiologies other than MS and NMO is also present . As for typical clinical features in demyelinating ON, acute or subacute unilateral visual loss (in progression over a few days up to 2 weeks) and any type of visual field defect with normal macula and peripheral retina, periocular pain and painful eye movement are supposed . On the other hand, our patients showed sudden visual loss with sub-ILM hemorrhage in the right eye, and the onset of simultaneously bilateral ON with optic disc hemorrhages. Therefore, we assessed this ON as a secondary ON associated with KFD.
The occurrence of sub-ILM hemorrhage in the right eye, and subsequently the development of bilateral optic disc hemorrhages with swollen optic discs could help to understand the potential pathogenic mechanisms in the acute phase of KFD. In this study, serologic investigations indicated temporary thrombophilia supported by elevated fibrinogen and D-dimer levels as well as decreased protein S (Supplementary Table 1). Furthermore, the AH levels of VEGF and G-CSF, which are related to neovascularization via the participation of bone marrow cells [27, 28], were extremely high compared to the levels in senile cataract patients as healthy elderly controls , and were similar to the levels in patients with acute primary angle-closure [29, 30], implying intraocular ischemia . In addition, bilateral optic disc hemorrhages occurred, although blood pressure and headache were properly controlled in the hospital. Zou et al.  reported occlusive retinal vasculitis in KFD patient, and proposed possible pathogenic mechanisms as follows: (1) immune complex depositions in the retinal vessels, and (2) cell-mediated inflammations mediated by activated macrophages infiltrating the walls of retinal vessels . Therefore, we hypothesize that immune complex depositions associated with microthrombus could have caused collapse of the retinal vessels and induce optic neuritis, resulting in the occurrence of sub-ILM hemorrhage and bilateral optic disc hemorrhages.
Premacular subhyaloid hemorrhage is typically characterized by a circumscribed, round or dumb-bell shaped, bright red mound of blood beneath the ILM or between the ILM and hyaloid face, in or near the central macular area [33, 34]. It may occur in retinal vascular disorders such as proliferative diabetic retinopathy , microaneurysm  and arterio-venous communication of the retina ; in hematological disorders such as aplastic anemia and leukemia ; following laser in situ keratomileusis ; after retinal vascular rupture associated with physical exertion (valsalva)  and Purtscher’s retinopathy , which were excluded based on laboratory test data and his clinical course. Although spontaneous resolution of premacular subhyaloid hemorrhage is expected in most cases, the resolution process takes several weeks or months depending on the thickness and total amount of blood present, which often incapacitates the patient . Furthermore, it may cause permanent visual impairment due to pigmentary macular changes or formation of epiretinal membranes and toxic damage to the retina due to prolonged contact with hemoglobin and iron . Thus, the sub-ILM hemorrhage should be resolved as soon as possible.
To resolve premacular subhyaloid hemorrhage, several surgical techniques have been described, including Nd:YAG laser hyaloidotomy [39, 40], pneumatic displacement of hemorrhage by intravitreal injection of gas and tissue plasminogen activator , and pars plana vitrectomy . Nd:YAG laser hyaloidotomy is a minimally invasive therapy that permits rapid drainage of premacular subhyaloid hemorrhage into the vitreous cavity, and improves visual acuity within a few days by clearance of the obstructed macular area [39, 43]. As complications of Nd:YAG laser hyaloidotomy, the formation of epiretinal membrane and contraction of ILM may occur [39, 44]. In the present case, the patient was a teenager, therefore minimally invasive therapy with rare complications including secondary cataract formation was a requisite. Hence, we selected Nd:YAG laser hyaloidotomy as the most appropriate therapy for him.
In conclusion, sub-ILM hemorrhage and optic disc hemorrhage may occur in KFD. Physicians should be aware of KFD-related ocular complications, when KFD patients complain of vision problems.
Availability of data and materials
Best-corrected visual acuity
Cerebrospinal fluid pressure
Granulocyte colony-stimulating factor
Herpes simplex virus
Inner limiting membrane
Inner limiting membrane
Interferon gamma-induced protein 10
The logarithm of the minimum angle of resolution
Polymerase chain reaction
Ribosomal ribonucleic acid
Spectral-domain optical coherence tomography
Systemic lupus erythematosus
Vascular endothelial growth factor
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The authors thank Takayuki Kanda, Noriaki Tachi, Yuji Tanaka, Toshikatsu Kaburaki, for their contribution to the present report.
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Sato, T., Kanda, K., Kawamura, Y. et al. Sub internal limiting membrane hemorrhage followed by bilateral optic disc hemorrhage in Kikuchi-Fujimoto disease: a case report. BMC Ophthalmol 21, 355 (2021). https://doi.org/10.1186/s12886-021-02106-y
- Kikuchi-Fujimoto disease
- Sub internal limiting membrane hemorrhage
- Optic disc hemorrhage
- Neodymium:yttrium-aluminum-garnet laser