Table 1 Clinical stages and severity in different single gene mutations
From: Long-term clinical prognosis of 335 infant single-gene positive FEVR cases
Gene | Stage zero | Stage one | Stage two | Stage three | Stage four | Stage five | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Eyes | Percentage | Eyes | Percentage | Eyes | Percentage | Eyes | Percentage | Eyes | Percentage | Eyes | Percentage | |
LRP5 | 12 | 6.3% | 40 | 21.1% | 23 | 12.1% | 16 | 8.4% | 61 | 32.1% | 38 | 20.0% |
FZD4 | 9 | 6.0% | 28 | 18.7% | 17 | 11.3% | 8 | 5.3% | 57 | 38.0% | 31 | 20.7% |
KIF11 | 3 | 2.5% | 9 | 7.6% | 27 | 22.9% | 4 | 3.4% | 50 | 42.4% | 25 | 21.2% |
NDP | 1 | 1.0% | 3 | 3.1% | 9 | 9.4% | 1 | 1.0% | 17 | 17.8% | 65 | 67.7% |
TSPAN12 | 3 | 3.3% | 7 | 7.6% | 23 | 25.0% | 2 | 2.2% | 51 | 55.4% | 6 | 6.5% |
ZNF408 | 4 | 16.7% | 1 | 4.2% | 9 | 37.5% | 2 | 8.3% | 5 | 20.8% | 3 | 12.5% |