Table 1 Clinical trials investigating the associations between homocysteine and folate and RAO and RVO
Source | Study type | NO. of pts | Mean age (yrs) | Mean folate (ng/dl) | P value | Mean homocysteine (µmol/l) | P value |
|---|---|---|---|---|---|---|---|
RAO Pianka et al. (2000) [37] | Case-control | 13 | 69.38 | Â N/A | N/A | 12.5 | 0.0034 |
Weger et al. (2002) [36] | Case-control | 105 | 69.1 | 5.6 | 0.040 | 12.2 | 0.003 |
Narin et al. (2004) [35] | Case-control | 20 | 55.8 |  N/A | N/A | 21.23 | < 0.08 |
RVO Weger et al. (2002) [44] | Case-control | 84 | 68.1 | 4.5 | 0.007 | 11.4 | 0.002 |
Yildirim et al. (2004) [33] | Case-control | 23 | 61 | 6.3 | 0.82 | 11.7 | 0.005 |
Gao et al. (2006) [14] | Case-control | 64 | 59.5 | 5.62 | 0.032 | 13.83 | 0.003 |
Sofi et al. (2008) [39] | Case-control | 262 | 66 | 5.5 | < 0.0001 | 12.4 | < 0.0001 |
Napal et al. (2021) [38] | Case-control | 368 | 67.9 | 7 | < 0.001 | 13.4 | < 0.0001 |