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  1. Adult-onset Still’s disease is a systemic inflammatory disease which presents with uveitis and scleritis in the eye. Intravitreal dexamethasone implants are used for the treatment of refractory uveitis.

    Authors: Seong Joon Ahn, Sun Jin Hwang and Byung Ro Lee
    Citation: BMC Ophthalmology 2016 16:196
    Content type: Case report Published on:

  2. Mutations of Crb1 gene cause irreversible and incurable visual impairment in humans. This study aims to use an LCA8-like mouse model to identify host-mediated responses that might interfere with survival, reti...

    Authors: Seo-Hee Cho, Ji Yun Song, Jinyeon Shin and Seonhee Kim
    Citation: BMC Ophthalmology 2016 16:193
    Content type: Research article Published on:

  3. Congenital cataracts are often complicated by anterior segment dysgenesis. This study aims to compare bilateral anterior segment parameters, macular thickness, and best-corrected visual acuity (BCVA) in pediat...

    Authors: Erping Long, Jingjing Chen, Zhenzhen Liu, Zhuoling Lin, Qianzhong Cao, Xiayin Zhang, Xiaoyan Li, Lixia Luo, Haotian Lin, Weirong Chen and Yizhi Liu
    Citation: BMC Ophthalmology 2016 16:192
    Content type: Research article Published on:

  4. The repertoire of free-living protozoa in contact lens solutions is poorly known despite the fact that such protozoa may act as direct pathogens and may harbor intra-cellular pathogens.

    Authors: Ibtissem Bouchoucha, Aurore Aziz, Louis Hoffart and Michel Drancourt
    Citation: BMC Ophthalmology 2016 16:191
    Content type: Research article Published on:

  5. Ocular allergy is a growing public health problem that greatly impacts the day-to-day life of sufferers and their families. Other aspects of their activities of daily living such as schooling, professional, an...

    Authors: Samuel Kyei, Bernard Tettey, Kofi Asiedu and Agnes Awuah
    Citation: BMC Ophthalmology 2016 16:190
    Content type: Research article Published on:

  6. To study the value and safety of aqueous humor polymerase chain reaction (PCR) analysis for Herpes simplex, varicella zoster, cytomegalovirus, Epstein-Barr virus and Toxoplasma gondii in patients with uveitis.

    Authors: Argyrios Chronopoulos, Daniel Roquelaure, Georges Souteyrand, Jörg Dieter Seebach, James Scott Schutz and Gabriele Thumann
    Citation: BMC Ophthalmology 2016 16:189
    Content type: Research article Published on:

  7. In 2014, the overall rate of smartphone use in Korea was 83 and 89.8 % in children and adolescents. The rate of smartphone use differs according to region (urban vs. rural) and age (younger grade vs. older gra...

    Authors: Jun Hyung Moon, Kyoung Woo Kim and Nam Ju Moon
    Citation: BMC Ophthalmology 2016 16:188
    Content type: Research article Published on:

  8. Patients with initially low visual acuity were excluded from the therapy approval studies for retinal vein occlusion. But up to 28 % of patients presenting with central retinal vein occlusion have a baseline B...

    Authors: Sibylle Winterhalter, Gerrit Alexander vom Brocke, Daniel Pilger, Annabelle Eckert, Juliane Schlomberg, Anne Rübsam, Matthias Karl Klamann, Enken Gundlach, Tina Dietrich-Ntoukas and Antonia Maria Joussen
    Citation: BMC Ophthalmology 2016 16:187
    Content type: Research article Published on:

  9. Intrachoroidal cavitation (ICC) in the temporal peripapillary area is a relatively frequent finding in high myopia. However, ICC associated with a full thickness retinal defect rarely observed. We report an un...

    Authors: Yoshiyuki Kita, Makoto Inoue, Gábor Hollό, Ritsuko Kita, Masahiko Sano and Akito Hirakata
    Citation: BMC Ophthalmology 2016 16:186
    Content type: Case report Published on:

  11. Refractive error is the main cause of visual impairment in the world. Spectacles are the most frequently used options for correcting refractive errors. In addition, they can be used for protection and fashion....

    Authors: Alemayehu Desalegn, Asamer Tsegaw, Destaye Shiferaw and Haile Woretaw
    Citation: BMC Ophthalmology 2016 16:184
    Content type: Research article Published on:

  13. The aim of this study was to determine the interocular differences in the peripapillary retinal nerve fibre layer (RNFL), peripapillary choroidal thickness (PCT) and subfoveal choroidal thickness (SFCT) in hea...

    Authors: Mo Yang, Wei Wang, Quangang Xu, Shaoying Tan and Shihui Wei
    Citation: BMC Ophthalmology 2016 16:182
    Content type: Research article Published on:

  15. To introduce a modified surgical technique, the “parafoveal multiple curvelinear internal limiting membrane (ILM) peeling”, to preserve epi-foveal ILM in myopic foveoschisis surgery.

    Authors: Haiying Jin, Qi Zhang and Peiquan Zhao
    Citation: BMC Ophthalmology 2016 16:180
    Content type: Technical advance Published on:

  16. To compare refractive outcomes after cataract surgery between patients with closed-angle and open-angle glaucoma and evaluate the influence of preoperative factors on refractive outcomes in patients with glauc...

    Authors: Young Cheong Kim, Mi Sun Sung, Hwan Heo and Sang Woo Park
    Citation: BMC Ophthalmology 2016 16:179
    Content type: Research article Published on:

  17. Phlyctenular keratitis is a hypersensitivity reaction of the cornea, and a complication of eyelid margin disease in children and young adults. In this study, we compared the morphology of the meibomian glands ...

    Authors: Takashi Suzuki, Naoyuki Morishige, Reiko Arita, Shizuka Koh, Tohru Sakimoto, Rika Shirakawa, Kazunori Miyata and Yuichi Ohashi
    Citation: BMC Ophthalmology 2016 16:178
    Content type: Research article Published on:

  19. Though the development and fitting of scleral contact lenses are expanding steadily, there is no simple method to provide scleral metrics for scleral contact lens fitting yet. The aim of this study was to est...

    Authors: Sang-Mok Lee, Hyuk Jin Choi, Heejin Choi, Mee Kum Kim and Won Ryang Wee
    Citation: BMC Ophthalmology 2016 16:176
    Content type: Research article Published on:

  21. To assess the efficacy of bandage contact lens (BCL) application to promote epithelialization and alleviate pain following corneal transplantation.

    Authors: Jun Shimazaki, Chika Shigeyasu, Yumiko Saijo-Ban, Murat Dogru and Seika Den
    Citation: BMC Ophthalmology 2016 16:174
    Content type: Research article Published on:

  23. VKH is a rare autoimmune disease. Decreased level of vitamin D has recently been found to be involved in the pathogenesis of Vogt-Koyanagi-Harada (VKH) disease. This study was designed to screen the vitamin D ...

    Authors: Ma’an Abdullah Al-Barry, Alia M Albalawi, Mohammed Abu Sayf, Abdulrahman Badawi, Sibtain Afzal, Muhammad Latif, Mohammed I. Samman and Sulman Basit
    Citation: BMC Ophthalmology 2016 16:172
    Content type: Research article Published on:

  24. In 2014, Pang et al. reported three cases with vitelliform submaculopathy as a preceding lesion of primary intraocular lymphoma (PIOL). Here, we report a case with an atypical presentation of PIOL who initiall...

    Authors: Koji Komatsu, Tsutomu Sakai, Toshikatsu Kaburaki, Hideki Tsuji and Hiroshi Tsuneoka
    Citation: BMC Ophthalmology 2016 16:171
    Content type: Case report Published on:

  25. Maple syrup urine disease (MSUD) is a rare metabolic disorder, affecting the metabolism of branched chain amino-acids (Valine, Leukine, Isoleukine). We present a rare case of rhegmatogenous retinal detachment ...

    Authors: Menelaos G. Kanakis, Helen Michelakakis, Petros Petrou, Chrysanthi Koutsandrea and Ilias Georgalas
    Citation: BMC Ophthalmology 2016 16:170
    Content type: Case report Published on:

  26. Intravitreal injections (IVI) of anti-vascular endothelial growth factor (anti-VEGF) now improve or stabilize visual acuity in a number of previously untreatable eye diseases, of which the main are age-related...

    Authors: Dordi Austeng, Tora Sund Morken, Stine Bolme, Turid Follestad and Vidar Halsteinli
    Citation: BMC Ophthalmology 2016 16:169
    Content type: Study protocol Published on:

  27. Evidences have identified the correlation of 8-oxoguanine DNA glycosylase-1 (OGG1) and eph-receptor tyrosine kinase-type A2 (EPHA2) polymorphisms in age-related cataract (ARC) risk. However, the results were n...

    Authors: Hongxu Zhang, Jianguang Zhong, Zhenyu Bian, Xiang Fang, You Peng and Yongping Hu
    Citation: BMC Ophthalmology 2016 16:168
    Content type: Research article Published on:

  28. Vernal keratoconjunctivitis (VKC) is a common cause of ocular morbidity in children in warm dry climates such as Sub–Saharan Africa and accounts for about 3 % of serious ophthalmic cases in tropical countries....

    Authors: Dereje Hayilu, Kbrom Legesse, Natinael Lakachew and Mulusew Asferaw
    Citation: BMC Ophthalmology 2016 16:167
    Content type: Research article Published on:

  29. Postoperative adhesion is one of the major complications of strabismus surgery and result in motility dysfunction that brings unpredictable surgical outcomes. However, there was no definitely accepted treatmen...

    Authors: Sang Uk Choi, Kyoung Woo Kim and Nam Ju Moon
    Citation: BMC Ophthalmology 2016 16:166
    Content type: Research article Published on:

  30. Discovery of sessile mode of microbial existence (Biofilm state) focussed much interest, during the recent years, on the study of biofilms in many recurring and chronic infections. However, the exact role of m...

    Authors: Niranjan Nayak, Gita Satpathy, Sujata Prasad, Alok Thakar, Mahesh Chandra and TC Nag
    Citation: BMC Ophthalmology 2016 16:165
    Content type: Research article Published on:

  31. Dry eye disease (DED) is multifactorial, affecting 5–34 % of the global adult population and reducing quality of life. The artificial tears or lubricants are the therapy most used for the treatment of DED, due...

    Authors: Ana L. Pérez-Balbuena, Juan C. Ochoa-Tabares, Sandra Belalcazar-Rey, Cristian Urzúa-Salinas, Laura R. Saucedo-Rodríguez, Regina Velasco-Ramos, Raúl G. Suárez-Sánchez, Adolfo D. Rodríguez-Carrizalez and Aldo A. Oregón-Miranda
    Citation: BMC Ophthalmology 2016 16:164
    Content type: Research article Published on:

  32. To compare corneal epithelial thickness (CET) and limbal epithelial thickness (LET) measured by anterior segment optical coherence tomography (AS-OCT) and in vivo confocal microscope (IVCM) in normal subjects,...

    Authors: Qihua Le, Yan Chen, Yujing Yang and Jianjiang Xu
    Citation: BMC Ophthalmology 2016 16:163
    Content type: Research article Published on:

  33. In randomized, controlled trials of open-angle glaucoma (OAG) or ocular hypertension (OHT), bimatoprost 0.01 % improved tolerability while retaining the intraocular pressure (IOP)-lowering efficacy of bimatopr...

    Authors: Ying Ying Chen, Tsing-Hong Wang, Catherine Liu, Kwou-Yeung Wu, Shin-Lin Chiu, Susan Simonyi and Da-Wen Lu
    Citation: BMC Ophthalmology 2016 16:162
    Content type: Research article Published on:

  34. To objectively compare the early changes in vault over time following implantation of an Implantable Collamer Lens without (ICL V4) and with (ICL V4c) a central hole and the respective factors affecting vault ...

    Authors: Xun Chen, Huamao Miao, Rajeev Krishnan Naidu, Xiaoying Wang and Xingtao Zhou
    Citation: BMC Ophthalmology 2016 16:161
    Content type: Research article Published on:

  35. To determine the most effective route of administration of corticosteroids in the treatment of ocular surface disease, by characterizing the difference between oral prednisolone and topical dexamethasone admin...

    Authors: Kaoru Araki-Sasaki, Osamu Katsuta, Hidetoshi Mano, Takashi Nagano and Masatsugu Nakamura
    Citation: BMC Ophthalmology 2016 16:160
    Content type: Research article Published on:

  36. Omega-3 polyunsaturated fatty acids (PUFAs) have a highly anti-angiogenic effect in animal models. However, the clinical relevance of omega-3PUFAs in human retinal pathologies remains unclear. The ARED 2 study...

    Authors: Anima D. Bühler, Felicitas Bucher, Michael Augustynik, Jan Wöhrl, Gottfried Martin, Günther Schlunck, Hansjürgen Agostini, Daniel Böhringer, Gerhard Pütz and Andreas Stahl
    Citation: BMC Ophthalmology 2016 16:159
    Content type: Research article Published on:

  37. Reis-Bücklers corneal dystrophy (RBCD) was consistently reported as a corneal dystrophy only affected Bowman’s layer and superficial corneal stroma, and superficial keratectomy was a recommendation surgery for...

    Authors: Wen-Ya Qiu, Li-Bin Zheng, Fei Pan, Bei-Bei Wang and Yu-Feng Yao
    Citation: BMC Ophthalmology 2016 16:158
    Content type: Research article Published on:

  38. Literature reports on ophthalmological manifestations related to tularemia, a zoonose caused by the bacterium Francisella tularensis, largely refer to Parinaud’s oculoglandular syndrome, which consists of the ass...

    Authors: Céline Terrada, Said Azza, Bahram Bodaghi, Phuc Le Hoang and Michel Drancourt
    Citation: BMC Ophthalmology 2016 16:157
    Content type: Case report Published on:

  39. Methylenetetrahydrofolate reductase (MTHFR), a critical enzyme in folate metabolism is involved in DNA synthesis, DNA repair and DNA methylation. The functional polymorphism of MTHFR gene, C677T has been shown to...

    Authors: Hamoud Al-Shahrani, Najwa Al-Dabbagh, Nourah Al-Dohayan, Misbahul Arfin, Mohammad Al-Asmari, Sadaf Rizvi and Abdulrahman Al-Asmari
    Citation: BMC Ophthalmology 2016 16:156
    Content type: Research article Published on:

  40. Iridocorneal endothelial (ICE) syndrome occurs mainly in young and middle-aged women and typically presents as a unilateral disease characterized by abnormalities of the iris and corneal endothelium. While the...

    Authors: Keita Suzuki, Tadashi Mizuguchi, Yui Seno, Atsuhiro Tanikawa and Masayuki Horiguchi
    Citation: BMC Ophthalmology 2016 16:155
    Content type: Case report Published on:

  42. Non-arteritic anterior ischemic optic neuropathy (NA-AION) is one of the most common types of ischemic optic neuropathy. Several recent studies suggested that abnormalities of choroidal thickness might be asso...

    Authors: Libin Jiang, Lanlan Chen, Xiujuan Qiu, Ran Jiang, Yaxing Wang, Liang Xu and Timothy Y. Y. Lai
    Citation: BMC Ophthalmology 2016 16:153
    Content type: Research article Published on:

  44. Myopia has become a significant global public health concern, and is highly prevalent worldwide especially in Asian countries. It is associated with genetic factors as well as socioeconomic status; however, th...

    Authors: Xiaoyan Wu, Guopeng Gao, Juxiang Jin, Wenjuan Hua, Liming Tao, Shaojun Xu and Fangbiao Tao
    Citation: BMC Ophthalmology 2016 16:151
    Content type: Research article Published on:

  45. To present a comprehensive approach for the management of patients with neovascular glaucoma (NVG) aiming to preserve visual function and complement pan-retinal photocoagulation (PRP) by anti-vascular endothel...

    Authors: Yaoyao Sun, Yong Liang, Peng Zhou, Huijuan Wu, Xianru Hou, Zeqin Ren, Xiaoxin Li and Mingwei Zhao
    Citation: BMC Ophthalmology 2016 16:150
    Content type: Research article Published on:

  48. Exercise reduces intraocular pressure (IOP) in the short term. However, it is not known whether exercise contributes to slower glaucomatous visual field defect progression.

    Authors: Satoshi Yokota, Yuji Takihara, Kanako Kimura, Yoshihiro Takamura and Masaru Inatani
    Citation: BMC Ophthalmology 2016 16:147
    Content type: Research article Published on:

  50. To evaluate the short-term reproducibility of diurnal intraocular pressure (IOP) and ocular perfusion pressure (OPP) measurements in normal volunteers, untreated normal-tension glaucoma (NTG) and primary open-...

    Authors: Yanlin Gao, Bing Wan, Peiyu Li, Yan Zhang and Xin Tang
    Citation: BMC Ophthalmology 2016 16:145
    Content type: Research article Published on:
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