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Is the NEI-VFQ-25 a useful tool in identifying visual impairment in an elderly population?



The use of self-report questionnaires to substitute for visual acuity measurement has been limited. We examined the association between visual impairment and self reported visual function in a population sample of older people in the UK.


Cross sectional study of people aged more than 75 years who initially participated in a trial of health screening. The association between 25-item National Eye Institute Visual Function Questionnaire (NEI-VFQ) scores and visual impairment (defined as an acuity of less than 6/18 in the better eye) was examined using logistic regression.


Visual acuity and NEI-VFQ scores were obtained from 1807 participants (aged 77 to 101 years, 36% male), from 20 general practices throughout the UK. After adjustment for age, gender, practice and NEI-VFQ sub-scale scores, those complaining of poor vision in general were 4.77 times (95% CI 3.03 to 7.53) more likely to be visually impaired compared to those who did not report difficulty. Self-reported limitations with social functioning and dependency on others due to poor vision were also associated with visual impairment (odds ratios, 2.52, 95% CI 1.55 to 4.11; 1.73, 95% CI 1.05 to 2.86 respectively). Those reporting difficulties with near vision and colour vision were more likely to be visually impaired (odds ratios, 2.32, 95% CI 1.30 to 4.15; 2.25, 95% CI 1.35 to 3.73 respectively). Other NEI-VFQ sub-scale scores were unrelated to measures of acuity. Similar but weaker odds ratios were found with reduced visual acuity (defined as less than 6/12 in the better eye). Although differences in NEI-VFQ scores were small, scores were strongly associated with visual acuity, binocular status, and difference in acuity between eyes.


NEI-VFQ questions regarding the quality of general vision, social functioning, visual dependency, near vision and colour vision are strongly and independently associated with an objective measure of visual impairment in an elderly population.

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Visual acuity is a clinical measure of an individual's ability to perform specific visual tasks. Previous population-based studies have shown that reduced visual acuity, so called 'visual impairment', is related to an individual's everyday task performance and self-reported difficulty with everyday tasks related to vision [13]. The National Eye Institute Visual Function Questionnaire (NEI-VFQ) was developed to give a self-reported measure of visual function. A 51-item questionnaire was originally devised in the US from focus groups of people with major causes of eye disease [4]. The questionnaire was later shortened to 25 items, based predominantly on the responses from those with eye disease and visual impairment, and also from a minority group without eye disease [5]. The shortened questionnaire has been validated and used to show that those with ocular disease and accompanying visual impairment have lower scores compared to a reference group without ocular disease or visual impairment [68]. The use of self-report questionnaires to substitute for visual acuity measurement has been limited [9], although the NEI-VFQ has been used in adult populations (aged 40 years or more) to show that those with visual impairment have lower scores compared to those without reduced visual acuity [10, 11]. However, concerns about the validity of certain sub-scales used in the NEI-VFQ and its range of measurement have been raised [12]. In addition, use of the NEI VFQ in non-US populations is limited, especially amongst older populations who are likely to experience higher levels of visual difficulties than younger age groups.

We have examined the association between responses to the NEI-VFQ and objective measures of visual impairment (based on established cut-offs in visual acuity). The extent of reported visual difficulties amongst an elderly population (aged over 75 years) in the UK is also described.


The study design is a cross sectional study of those who initially participated in the Medical Research Council's (MRC) trial of assessment and management of older people in the community. Details of the trial have been described in detail elsewhere [13]. In brief, 106 general practices from the UK Medical Research Council General Practice Research Framework were recruited to the trial. The sampling of practices was stratified by tertiles of Standardised Mortality Ratio (mortality experience of local area relative to national mortality) and Jarman score (an area deprivation measure indicator) to ensure a representative sample. Practices were randomised to two groups: targeted versus universal screening. In the universal screening group, all participants were invited to have a detailed health assessment by a research nurse that included visual acuity. All patients aged 75 years or over registered with participating general practices were included in the study, unless they were resident in a long stay hospital or psychogeriatric care facility or were terminally ill. People in sheltered or residential housing for the elderly were included. The examinations took place between 1995 and 1999. Three to five years later, as part of a nested trial evaluating the benefit of vision screening [14], 4340 previously sampled participants from 20 general practices were selected at random. Of the 2875 who were still alive, 2589 (90%) were invited to have an assessment of their vision and complete the 25-item NEI-VFQ. Research nurses measured presenting monocular and binocular visual acuity (defined as using their habitual distance correction) on the logMAR scale using Glasgow acuity charts [15]. The 25 questions in the NEI-VFQ are grouped in 12 sub-scales (including general health, general vision, ocular pain, near activities, distance activities, social functioning, mental health, role difficulties, dependency, driving, colour vision and peripheral vision), as well as a combined total score (Table 1). Each sub-scale was calculated according to the methods described by the NEI-VFQ developers and can range from 0 to 100, where 0 is the worst and 100 represents no disability related to vision (that is, ratings of excellent or no difficulty). Demographic data including age, gender, and socioeconomic status were also collected. Socioeconomic status was measured using the Carstairs deprivation index, where low scores represent those from areas associated with less privileged circumstances [16].

Table 1 Questions used to derive NEI-VFQ sub-scale scores

In all analyses visual impairment was defined as a visual acuity equivalent to a Snellen acuity below 6/18 in the better eye (equivalent to the ICD-10 definition category 1 to 5) [17]; reduced visual acuity below 6/12 in the better eye was also considered. Both better eye and binocular acuity (acuity measured with both eyes open) were considered; using better eye acuity allowed the influence of differences in acuity between the eyes to be examined. Causes of visual impairment were not routinely collected. The relevant local research ethics committees of the participating practices approved the study.

Statistical methods

Statistical analysis was performed using STATA (version 7) taking account of the clustered design of the study (i.e. general practice). All analyses were adjusted for age, gender, and general practice (fitted as a fixed effect to allow for between practice consulting behaviour and for geographical location). Logistic regression was used to examine whether the odds of visual impairment were related to age, gender, socioeconomic status, and NEI-VFQ scores. Age was divided into 3 groups (75 to <80, 80 to 85 and >85), Carstairs deprivation index into quartiles (a missing category of Carstairs deprivation index was also included). With the exception of general health, the majority of respondents reported 'no problems' (that is scores of 100) in the NEI-VFQ subscales (or good to excellent eyesight for general vision) and in the analyses the NEI-VFQ subscales were grouped into those reporting 'problems' versus 'no problems'. Self reported general health and the Total VFQ score were divided into quartiles (using the XTILE command in STATA). For the general health domain, this resulted in the responses 'excellent' and 'very good' being combined (as there were few responses to excellent health), to give a group defined as having no problems. The remaining responses were defined as having poor or moderate health or having few problems with general heath. Odds ratios comparing the baseline group reporting no problems with the remainder being split into 3 approximately equal sized groups were calculated. The independent influence of sub-scale scores on visual impairment was examined after adjustment for other scores (except driving due to the small proportion of drivers).

We also quantified change in NEI-VFQ scores and the proportion of the variability (R2 values) in scores, attributed to age, gender, general practice, logMAR acuity in the better eye (as a categorical variable), binocular status (monocular or binocular) and difference in acuity between the eyes (as a continuous variable) using linear regression models. To normalise heavily skewed VFQ scores, an appropriate transformation was achieved by log transformation after adding a constant (using the LNSKEW command in STATA). This was only possible for general vision, near activities, and the total VFQ score. A similar procedure has been described elsewhere [8].


In total, 4340 older people from the 20 practices had participated in the initial health screen between 1995 and 1999. Three to five years later 1465 participants had died, 252 had moved away and 34 could not be traced. Of the 2875 surviving participants, 2589 (90%) were invited to a vision test, 1807 participated (70%), 670 refused (26%) and 112 (4%) were too ill. The mean age of participants was 83 years (77 to101 years); and the majority were female (64%). Complete data, including a measure of visual acuity and a completed NEI-VFQ, were available for 1785 participants. The prevalence of reduced visual acuity less than 6/12 in the better eye was 33% (n = 585/1785), and 14% (n = 243/1785) for visual impairment (defined as visual acuity less than 6/18 in the better eye). The cause of visual impairment was only available for an unrepresentative minority of participants, and is not considered further.

Table 2 shows the influence of age, gender, social economic status, NEI-VFQ sub-scale and total scores on visual impairment. The likelihood of visual impairment increased sharply with age. Females were more likely than males to be visually impaired even after adjustment for age. There was a weak association with Carstairs Index with those living in less privileged areas being less likely to have visual impairment; the association between Carstairs index and reduced visual acuity was similar but appeared stronger. Of the NEI-VFQ sub-scales, self-reported general health was moderately associated with visual impairment and there was no association with ocular pain. Reporting of problems in the remaining VFQ sub-scales and total scores were strongly related to visual impairment. In a subgroup that responded to questions concerning driving, visual impairment was strongly related to increased difficulties with driving. Associations with worst eye as well as better eye acuity were also examined; in general, associations were similar but weaker (data not presented).

Table 2 Association between age, gender, social status, NEI-VFQ sub-scale scores and visual impairment

As different sub-scales scores may be inter-related (that is, difficulty with general vision may reflect difficulties with near and/or distance vision) the independent influence of these scores on visual impairment was determined (Table 3). After adjustment for demographic and other sub-scale scores, difficulties with general vision, near activities, and social functioning remained associated with visual impairment. Difficulties with dependency and colour vision were of borderline statistical significance.

Table 3 Association between NEI-VFQ sub-scale scores and visual impairment, adjusted for age, gender, practice and other sub-scale scores listed in the table

The independent influence of visual acuity, binocular status, and differences in visual acuity between eyes on log transformed scores for general vision, near activities, and total VFQ scores was examined using linear regression (Table 4). Differences in acuity between eyes were defined as less than or equal to a 0.1 difference in LogMAR acuity (equivalent to a difference in Snellen acuity from 6/9 to 6/12) or greater, and compared to those with equal acuity. Although overall differences in these scores were small (e.g. inter quartile range 83 to 97 for the total score) compared to the possible range of measurement (from 0 to 100), scores were strongly related to differences in visual acuity, binocular or monocular status, and differences in acuity between eyes. To examine the relative contribution of visual acuity, demographic factors, binocularity, and between eye differences in acuity in explaining variation in total VFQ scores, the correlations of determination (R2 values) for different accumulative linear regression models are given in Table 5. The R2 value gives the proportion of the variability in total scores explained by different exposure variables. For instance, visual acuity alone explains 16% of the variability in the total score. The addition of demographic variables, binocular status, and difference in acuity between eyes results in 27% of the variability being explained (an increase of 19%). Hence, although visual acuity alone, only accounts for less than a fifth of the variability, it appears to be the most important determinant of total VFQ score.

Table 4 Mean scores (95% CI) by visual acuity (better eye), binocular status, and by between eye differences in visual acuity
Table 5 Variance in total domain scores explained by visual acuity (better eye), demographic variables, binocular status, and difference in acuity between eyes


In this older population, self-reported difficulties with general vision, near activities, colour vision, vision related social functioning, and dependency on others to perform visual tasks were associated independently with reduced visual acuity and visual impairment. These findings are in agreement with other studies where loss of vision has been found to be associated with increased social isolation, depression [11, 18], and restriction of daily activities [19]. Reported difficulties with colour vision may reflect the increased likelihood of cataract within this elderly population [20]. These important sub-scale scores can be used to give an independent measure of visual difficulty amongst the elderly. Concerns have been raised about the validity of the NEI-VFQ in a general population, since it was developed primarily amongst those with eye disease, and scores tend to be high and with a limited range of measurement in the general population [12]. The general population used in this study was elderly where visual problems are more prevalent, and a substantial proportion of participants reported difficulties, especially with certain sub-scales. For example, over half reported difficulties with either distance or near activities, and around 40% reported difficulties with role difficulties, mental health and driving, and a quarter problems with peripheral vision. The NEI-VFQ is scored by summing the ranks of responses to certain questions for different domain scores (see Table 1), resulting in a Likert scale [21]. A similar approach is used for other visual function questionnaires [2123]. This approach assumes that the response to each question are of similar importance, and that each category of response represents an equal interval along a continuous dimension from 'no problems' to 'problems'. However, the intervals at the 'ceiling' and 'floor' of this scale are unbounded, which some argue invalidates the Likert scale derived [21, 23]. In addition, allowing participants not to answer certain questions as being no longer relevant (such as the questions used for distance activities, see Table 2), may invalidate the measure further. Despite these caveats we have shown strong associations between certain NEI-VFQ scores and cut-offs in visual acuity describing visual impairment and reduced visual acuity, suggesting that the everyday problems experienced in vision related activities are of considerable concern in this age group.

Visual acuity alone, although showing strong associations with NEI-VFQ scores and useful in population vision testing, is a relatively limited measure of vision performance – only explaining up to a fifth of the variation in total VFQ score (comparable to levels reported in other studies of populations with eye disease e.g. age related macular degeneration and glaucoma) [6, 7]. Adding other factors such as demographic variables (age, gender, and the general practice where subjects were examined), binocular status, and difference in acuity between eyes led to just over a quarter of the variation in total VFQ score being explained. Measures of deprivation were not related to self reported vision function. Hence, although visual acuity alone appears to be the most important determinant of the VFQ score, it only gives a limited measure of visual performance. It is possible that inclusion of a broader spectrum of tests, such as contrast sensitivity, colour vision and assessment of the visual field may provide a more comprehensive picture of visual performance. In addition, there will be a range of other social and psychological factors that influence a person's response to reduced vision. Alas, we collected only limited data on other possible influencing variables such as depression, social circumstances or personality at the follow up visit, as this was not the main focus of our study. Other studies support the conjecture that other measures besides visual acuity are associated with an individuals perception of visual performance [1, 24, 25].

Although this study showed that self-reported problems on the NEI-VFQ are associated with visual impairment, problems with some domain scores were more strongly associated with visual impairment (such as near activities, distance activities and general vision) than other domain scores (e.g. ocular pain and colour vision). On the basis of the total VFQ score categories (see Table 2) taking those classified with poor vision (in the lowest quartile of the VFQ score) as screen positive and the rest as screen negative, would result in a detection rate of visual impairment of 69% (168/242) and a false positive rate of 18% (270/1541). Thus approximately 1 in 5 people without visual impairment would be screen positive using this definition. The question referring to driving was more sensitive (93% = 38/41) but had a higher false positive rate (52% = 261/504), and was only answered by 30% of the sample.


We conclude that the NEI-VFQ appears to be a useful instrument for measuring visual difficulties that can be used in studies of elderly people with significant levels of visual impairment. The NEI-VFQ could be usefully employed when it is logistically or financially impossible to examine all subjects [26]. The VFQ measures important difficulties that are strongly related to definitions of visual impairment (based on established cut-offs in visual acuity), which might be used as an additional measure of visual ability.

Sources of support

Royal National Institute for the Blind (RNIB) and the Medical Research Council, UK.



National Eye Institute Visual Function Questionnaire


  1. Rubin GS, Bandeen-Roche K, Huang GH, Munoz B, Schein OD, Fried LP, West SK: The association of multiple visual impairments with self-reported visual disability: SEE project. Invest Ophthalmol Vis Sci. 2001, 42: 64-72.

    CAS  PubMed  Google Scholar 

  2. West SK, Rubin GS, Broman AT, Munoz B, Bandeen-Roche K, Turano K: How does visual impairment affect performance on tasks of everyday life? The SEE Project. Salisbury Eye Evaluation. Arch Ophthalmol. 2002, 120: 774-780.

    Article  PubMed  Google Scholar 

  3. Chia EM, Wang JJ, Rochtchina E, Smith W, Cumming RR, Mitchell P: Impact of bilateral visual impairment on health-related quality of life: the Blue Mountains Eye Study. Invest Ophthalmol Vis Sci. 2004, 45: 71-76. 10.1167/iovs.03-0661.

    Article  PubMed  Google Scholar 

  4. Mangione CM, Berry S, Spritzer K, Janz NK, Klein R, Owsley C, Lee PP: Identifying the content area for the 51-item National Eye Institute Visual Function Questionnaire: results from focus groups with visually impaired persons. Arch Ophthalmol. 1998, 116: 227-233.

    CAS  PubMed  Google Scholar 

  5. Mangione CM, Lee PP, Gutierrez PR, Spritzer K, Berry S, Hays RD: Development of the 25-item National Eye Institute Visual Function Questionnaire. Arch Ophthalmol. 2001, 119: 1050-1058.

    Article  CAS  PubMed  Google Scholar 

  6. Brody BL, Gamst AC, Williams RA, Smith AR, Lau PW, Dolnak D, Rapaport MH, Kaplan RM, Brown SI: Depression, visual acuity, comorbidity, and disability associated with age-related macular degeneration. Ophthalmology. 2001, 108: 1893-1900. 10.1016/S0161-6420(01)00754-0.

    Article  CAS  PubMed  Google Scholar 

  7. Jampel HD, Friedman DS, Quigley H, Miller R: Correlation of the binocular visual field with patient assessment of vision. Invest Ophthalmol Vis Sci. 2002, 43: 1059-1067.

    PubMed  Google Scholar 

  8. Klein R, Moss SE, Klein BE, Gutierrez P, Mangione CM: The NEI-VFQ-25 in people with long-term type 1 diabetes mellitus: the Wisconsin Epidemiologic Study of Diabetic Retinopathy. Arch Ophthalmol. 2001, 119: 733-740.

    Article  CAS  PubMed  Google Scholar 

  9. Coren S, Hakstian AR: Validation of a self-report inventory for the measurement of visual acuity. Int J Epidemiol. 1989, 18: 451-456.

    Article  CAS  PubMed  Google Scholar 

  10. Broman AT, Munoz B, Rodriguez J, Sanchez R, Quigley HA, Klein R, Snyder R, West SK: The impact of visual impairment and eye disease on vision-related quality of life in a Mexican-American population: proyecto VER. Invest Ophthalmol Vis Sci. 2002, 43: 3393-3398.

    PubMed  Google Scholar 

  11. Paz SH, Globe DR, Wu J, Azen SP, Varma R: Relationship between self-reported depression and self-reported visual function in Latinos. Arch Ophthalmol. 2003, 121: 1021-1027. 10.1001/archopht.121.7.1021.

    Article  PubMed  Google Scholar 

  12. Massof RW, Fletcher DC: Evaluation of the NEI visual functioning questionnaire as an interval measure of visual ability in low vision. Vision Res. 2001, 41: 397-413. 10.1016/S0042-6989(00)00249-2.

    Article  CAS  PubMed  Google Scholar 

  13. Evans JR, Fletcher AE, Wormald RP, Ng ES, Stirling S, Smeeth L, Breeze E, Bulpitt CJ, Nunes M, Jones D, Tulloch A: Prevalence of visual impairment in people aged 75 years and older in Britain: results from the MRC trial of assessment and management of older people in the community. Br J Ophthalmol. 2002, 86: 795-800. 10.1136/bjo.86.7.795.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  14. Smeeth L, Fletcher AE, Hanciles S, Evans J, Wormald R: Screening older people for impaired vision in primary care: cluster randomised trial. BMJ. 2003, 327: 1027-10.1136/bmj.327.7422.1027.

    Article  PubMed  PubMed Central  Google Scholar 

  15. McGraw PV, Winn B: Glasgow Acuity Cards: a new test for the measurement of letter acuity in children. Ophthalmic Physiol Opt. 1993, 13: 400-404.

    Article  CAS  PubMed  Google Scholar 

  16. Carstairs V, Morris R: Deprivation: explaining differences in mortality between Scotland and England and Wales. BMJ. 1989, 299: 886-889.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  17. World Health Organization: International Statistical Classification of Diseases and Related Health Problems: Tenth Revision. 1992, The World Health Organization, Geneva, Switzerland, 456-457.

    Google Scholar 

  18. Rovner BW, Zisselman PM, Shmuely-Dulitzki Y: Depression and disability in older people with impaired vision: a follow-up study. J Am Geriatr Soc. 1996, 44: 181-184.

    Article  CAS  PubMed  Google Scholar 

  19. Stuck AE, Walthert JM, Nikolaus T, Bula CJ, Hohmann C, Beck JC: Risk factors for functional status decline in community-living elderly people: a systematic literature review. Soc Sci Med. 1999, 48: 445-469. 10.1016/S0277-9536(98)00370-0.

    Article  CAS  PubMed  Google Scholar 

  20. Minassian DC, Reidy A, Desai P, Farrow S, Vafidis G, Minassian A: The deficit in cataract surgery in England and Wales and the escalating problem of visual impairment: epidemiological modelling of the population dynamics of cataract. Br J Ophthalmol. 2000, 84: 4-8. 10.1136/bjo.84.1.4.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  21. Massof RW: Likert and Guttman scaling of visual function rating scale questionnaires. Ophthalmic Epidemiol. 2004, 11: 381-399. 10.1080/09286580490888771.

    Article  PubMed  Google Scholar 

  22. Massof RW: The measurement of vision disability. Optom Vis Sci. 2002, 79: 516-552. 10.1097/00006324-200208000-00015.

    Article  PubMed  Google Scholar 

  23. Massof RW: Application of stochastic measurement models to visual function rating scale questionnaires. Ophthalmic Epidemiol. 2005, 12: 103-124. 10.1080/09286580590932789.

    Article  PubMed  Google Scholar 

  24. Brabyn J, Schneck M, Haegerstrom-Portnoy G, Lott L: The Smith-Kettlewell Institute (SKI) longitudinal study of vision function and its impact among the elderly: an overview. Optom Vis Sci. 2001, 78: 264-269. 10.1097/00006324-200105000-00008.

    Article  CAS  PubMed  Google Scholar 

  25. Klein BE, Klein R, Lee KE: Incidence of age-related cataract: the Beaver Dam Eye Study. Arch Ophthalmol. 1998, 116: 219-225.

    CAS  PubMed  Google Scholar 

  26. The Submacular Surgery Trials Research Group: Responsiveness of the National Eye Institute Visual Function Questionnaire to changes in visual acuity: findings in patients with subfoveal choroidal neovascularization--SST Report No. 1. Arch Ophthalmol. 2003, 121: 531-539. 10.1001/archopht.121.4.531.

    Article  PubMed Central  Google Scholar 

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This work was funded by a grant from the Royal National Institute for the Blind (RNIB), UK. The UK Medical Research Council funded the trial of assessment and management of older people in the community and the nested trial of vision impairment. The funding bodies did not participate in the study design. LS is supported by a Medical Research Council Clinician Scientist Fellowship.

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Correspondence to Christopher G Owen.

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All authors contributed to the formulation of the hypothesis. CGO and ARR performed the statistical analysis. CGO drafted the manuscript to which all authors contributed, and is guarantor. All authors read and approved the final manuscript.

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Owen, C.G., Rudnicka, A.R., Smeeth, L. et al. Is the NEI-VFQ-25 a useful tool in identifying visual impairment in an elderly population?. BMC Ophthalmol 6, 24 (2006).

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