Skip to main content

Retinal arterial macroaneurysm rupture by Valsalva maneuver: a case report and literature review



Retinal artery macroaneurysms (RAMs) are focal dilations of the large retinal arteries. Most RAMs are asymptomatic, however, when hemorrhage or exudation caused by a RAM involves the macula, patients can experience marked vision loss. This article reported a rare case of a ruptured RAM due to the Valsalva maneuver in an elderly female with constipation and offered a review of the relevant literature.

Case presentation

A 78-year-old woman with several risk factors presented with multi-level retinal hemorrhages following a Valsalva maneuver during constipation. Due to the poor coagulation and heavy bleeding in this case, the blood broke through the internal limiting membrane and drained "on its own" into the vitreous cavity. First, we observed the patient and controlled for her risk factors. After the blood was completely drained into the vitreous cavity, the root cause of the bleeding was found to be a RAM rupture. After laser photocoagulation, the patient's vision recovered significantly and remained stable for a long time despite the presence of an epiretinal membrane and a lamellar macular hole.


This is the first reported case of a RAM rupture by Valsalva maneuver during constipation. For multi-level hemorrhages caused by RAM, measures should be taken to drain out the sub-internal limiting membrane hemorrhage and simultaneously control for risk factors. After the RAM is exposed, laser photocoagulation can be performed.

Peer Review reports


Retinal arterial macroaneurysms (RAMs) are acquired focal dilatations of the large retinal arteries, usually occurring within the first three bifurcations of the central retinal artery [1]. Typically, RAMs are seen in elderly women and are usually closely related to long-standing hypertension and arteriosclerosis [2]. Most RAMs are located in the temporal retina, and many may regress spontaneously with a favorable prognosis [3, 4]. However, a marked decrease in visual acuity may result when the macula is involved by hemorrhages and exudates. The Valsalva maneuver is a forced expiration against a closed glottis causing transient systemic changes such as increased blood pressure and intraabdominal pressure [5]. It is quite common in daily life and typical activities such as coughing hard, vomiting, straining, constipation, and weightlifting can all lead to it [6]. The Valsalva maneuver can affect retinal arteries due to the sudden and violent fluctuation of blood pressure that occurs [7].

To the best of our knowledge, there have yet to be any reports of RAM rupture by a Valsalva maneuver-related mechanism. Here, we reported a rare case of the rupture of a retinal arterial macroaneurysm by the Valsalva maneuver in an elderly female with hypertension and constipation and provided a review of the relevant literature.

Case presentation

A 78-year-old female was admitted to our department for sudden-onset painless vision loss, central scotoma, and an “earthworm-shaped” floater in her left eye. These symptoms were noticed after she had a hard bowel movement the prior night. Examination demonstrated the best-corrected visual acuity (BCVA) of 20/40 in her right eye and finger counting in her left eye. Intraocular pressures were 16 mmHg and 14 mmHg in her left and right eye, respectively. A history of hypertension for 15 years was reported and she had been on oral antihypertensive medication. Her blood pressure at presentation was 146 over 83 mmHg. She had persistent atrial fibrillation for 5 years, so she was on long-term oral rivaroxaban (10 mg QD; Xarelto, Bayer Pharma AG). Moreover, 2 years ago, the patient had two coronary stents implanted due to coronary heart disease and she was taking oral aspirin (100 mg QD; Bayaspirin, Bayer Pharma AG). The patient also had a history of untreated constipation for more than 10 years. Any history of ocular disease or trauma was denied. Her eye movements, pupillary responses, and anterior segment examination were unremarkable in both eyes. Dilated fundus examination of the right eye showed drusens scattered at the posterior pole and examination of the left fundus showed the presence of asteroid hyalosis, vitreous hemorrhage (VH), as well as subretinal and sub-inner limiting membrane (sub-ILM) hemorrhage. Color fundus photographs (CFP) revealed that the strand-shaped appearance of VH was consistent with the patient's chief complaint of an “earthworm-shaped” floater (Fig. 1a and b). Fundus fluorescein angiography (FFA) and indocyanine green angiography (ICGA) showed the presence of retinal blood vessels in the upper part of the hemorrhage while those in the lower part were covered, representing subretinal and sub-ILM hemorrhage, respectively (Fig. 1 c and d). These two retinal hemorrhages were also clearly identified in Spectral-domain optical coherence tomography (SD-OCT; Spectralis HRA + OCT; Heidelberg Engineering, Heidelberg, Germany) (Fig. 1e and f). In addition, the epiretinal membrane (ERM) and a rupture of the inner limiting membrane (ILM) were noted at the junction of the VH and the sub-ILM hemorrhage in the macula (Fig. 1f). Blood chemistry tests show elevated triglycerides (2.1 mmol/L). Her blood cell count was normal, but the prothrombin time (PT) and activated partial thrombin time (APTT) were delayed (30.1 s and 45.8 s, respectively). The international normalized ratio (INR) was elevated (2.82). Based on her clinical presentation and history, a preliminary diagnosis of epiretinal membrane and Valsalva maneuver-related retinal hemorrhage and VH was made.

Fig. 1
figure 1

CFP, FFA, ICGA, and SD-OCT examinations of the patient on the first visit. CFP showed drusens scattered at the posterior pole of the right eye (a) as well as retinal hemorrhage, vitreous hemorrhage, and asteroid hyalosis in the left eye (b). In FFA (c) and ICGA (d), subretinal hemorrhage in the upper retina (arrowhead), sub-ILM hemorrhage in the macular area (white arrow), and strand-shaped VH (blue arrow) could be distinguished. SD-OCT with infrared image showed a fusiform lesion with a hyporeflective area under a hyperreflective band between the neurosensory retina and retinal pigment epithelium, according with subretinal hemorrhage (e). SD-OCT and infrared images demonstrated the presence of ERM (grey arrowhead), an arched hemorrhage below the ILM, and a rupture of the ILM (green arrowhead) in the macular area (f)

Because part of the retinal hemorrhage had drained into the vitreous cavity through the rupture of ILM, and considering the advanced age and concomitant diseases of the patient, regular follow-up examinations on ocular condition were advised. A careful dilated fundus examination was performed at each visit to observe the absorption of the hemorrhage and to facilitate the timely intervention for any adverse progression (All follow-up examinations were performed by Y.M., L.L., and L.H.). The patient was simultaneously referred to the department of cardiology for regulatory medication to control blood pressure, triglycerides, and the risk of bleeding. After six weeks, most of the retinal hemorrhage had been absorbed, with the exception of a small amount of the sub-ILM hemorrhage which was left in the supranasal macula (Fig. 2a). The infrared (IR) and OCT B-scan images revealed a retinal arterial macroaneurysm on the temporal side of the optic disc at the posterior pole, with a large area of ERM covering the posterior pole and minor sub-ILM hemorrhage (Fig. 2b and c). The BCVA was 20/40 in her right eye and 20/80 in her left eye. The patient and her family required quick and safe recovery of vision. After comparing the potential risks, benefits, and costs of surgery with laser and other treatments, they chose laser treatment. To speed up the regression of the RAM, 577-nm yellow laser photocoagulation (NIDEK MC-500 Vixi, Nidek, Gamagori, Japan) with 180 mW power was carefully performed at the RAM (by Y.X.). The duration was 0.2 s and the spot size was 200 μm using a single pulse. The patients did not report any discomfort after laser treatment.

Fig. 2
figure 2

Examinations of the patient 6 weeks after initial vision loss. The fundus photograph taken with the Optomap® camera and an amplified view of the fundus photograph showed a small fraction of VH (red arrowhead) and retinal hemorrhage (white arrowhead) that had not been absorbed (a). The RAM (white arrow) was discernible on the B-scan and IR images (b). B-scan and IR images showed the residual sub-ILM hemorrhage (blue arrow) covering the retina underneath (c). Both B-scans showed continuous band-shaped hyperreflective signals (pentagram) on the retinal surface, consistent with ERM (b and c)

Nine weeks after her initial visit, all retinal hemorrhages had been absorbed (Fig. 3a), and the patient's BCVA also improved to 20/40 for both eyes. CFP and SD-OCT showed a significant regression of the RAM following the laser photocoagulation (Fig. 3a and c). FFA confirmed the closure of the RAM without affecting the surrounding retinal vessels (Fig. 3b). Although ERM had been found since her first visit, it was observed without recommendation for treatment because it was not the main problem threatening the patient's vision at the current time. Six weeks after her initial visit, the formation of a lamellar macular hole was found just at the junction of the previous VH and sub-ILM hemorrhage. The ERM and lamellar macular hole remained stable during her subsequent follow-up visits (Fig. 4). Thus, the main diagnosis of this patient was RAM rupture induced by the Valsalva maneuver. Her ophthalmological manifestations remained stable for 8 months after the final diagnosis (Fig. 4). No adverse or unanticipated events had been observed till her latest follow-up. The patient was satisfied with the treatment effect.

Fig. 3
figure 3

Examinations of the patient 9 weeks after first visit (3 weeks after laser photocoagulation). CFP indicated that almost all of the hemorrhages at the posterior pole had been absorbed (a). After laser photocoagulation, the RAM (white arrow) was closed on FFA (b). SD-OCT demonstrated RAM shrinkage (c) and complete absorption of the residual sub-ILM hemorrhage (d). The ERM (pentagram) was stable (c and d)

Fig. 4
figure 4

IR and B-scan images of the same position from the patient's first visit to 10 months later. The ERM and lamellar macular hole had remained stable since the 6th week



There is no authoritative data yet on the incidence rate of RAMs, but they are most frequently seen in people over 60 [8, 9]. According to published literature, women account for 70% ~ 78% of RAM cases [8, 10,11,12]. The mostly reported location of RAMs is the superotemporal quadrant of the retina, partly because RAMs at this location are more likely to show visual symptoms [3, 13].

Risk factors

Known risk factors of RAMs include female sex, advanced age, systemic hypertension, hypercholesterolemia, polycythemia, and arteriosclerotic cardiovascular disease, among others [1, 9, 14,15,16]. Previous studies have suggested that hypertension is the most important risk factor, and the proportion of hypertension in patients with RAMs ranges from 51 to 75% [11, 12, 17]. Although there is no ocular risk factor that has been clearly confirmed by previous studies, several ocular diseases have been reported to be associated with RAMs, including retinal venous occlusion (RVO), retinal arterial occlusion (RAO), and macular hole (MH) [14, 18,19,20].


The precise pathophysiology of RAMs has not been well-understood to date. However, it has been recognized that RAMs are characterized by thinned blood vessel walls, decreased elasticity, and fibrosis secondary to the loss of the muscular coat, thus leading to increased susceptibility to dilatation by raised intraluminal pressure [14, 15]. The focal weakness of the arterial walls results in RAMs. And rupture of RAMs occurs when intravascular pressure exceeds the threshold that the fragile vessel walls can withstand. From this perspective, various focal or systemic factors leading to increased vessel wall susceptibility may be responsible for RAMs. For example, hyaline degeneration and arteriosclerosis of the retinal arteries are commonly seen in patients with sustained hypertension, and these conditions can partly explain why hypertension is the most important risk factor for RAMs [17, 21].

Clinical manifestations

The presentation of a patient with RAMs can be variable. RAMs can be classified into three types: hemorrhagic, exudative, and quiescent, between which the management and prognosis may differ [3]. Hemorrhagic RAMs are caused by the acute rupture of the fragile retinal artery walls. Depending on the location of the rupture, hemorrhagic RAMs can cause multi-level retinal hemorrhages and can be observed in the preretinal, sub-ILM, intraretinal, and subretinal spaces [21, 22]. VHs occur when blood breaks through the ILM and is drained into the vitreous. Exudative RAMs are marked by exudates with or without macular edema. If a RAM shows both exudates and hemorrhages, the type is based on the initial predominant complication causing decreased visual ability (VA) [2]. Contrary to the first two types, quiescent RAMs are generally asymptomatic with no obvious hemorrhages or exudates. However, hemorrhages and/or exudates could also be found in quiescent RAMs when the macula is not affected [2, 16]. Quiescent RAMs may develop into the hemorrhagic or exudative type. Typically, RAMs are unilateral, but there are reports of bilateral RAMs or multiple RAMs occurring in the same eye [23, 24]. Neurosensory retinal detachment and macular edema with or without exudations can also be seen in some cases [4]. RAMs might be found upon routine ophthalmic examination in patients without any ocular symptoms. However, most RAMs are found because of the abrupt and severe decrease in VA and loss of visual field that result from hemorrhages and exudates [11, 25, 26].

Diagnosis and differential diagnosis

The diagnosis of RAMs is typically made based on clinical manifestations, demographic characteristics, and examinations such as FFA, ICGA, and OCT [16, 26,27,28].

However, RAMs can be described as a masquerade syndrome and may mimic a range of other ocular diseases [29]. According to previous literature, RAMs are frequently misdiagnosed, especially when the underlying RAMs are obscured by hemorrhages or exudates [3, 14]. Considering that these studies were completed at a time when RAMs were not well understood and the means of inspection were more limited and less advanced, the current misdiagnosis rate should now be lower. Yet, it is still necessary and important to distinguish RAMs from other mimickers in clinical practice. For patients with retinal hemorrhages, mimickers such as RVO, diabetic retinopathy (DR), retinal telangiectasia (Coats’ disease and Leber's miliary aneurysms), Valsalva retinopathy, idiopathic polypoidal choroidal vasculopathy (IPCV), choroidal neovascularization (CNV), retinal capillary hemangiomas, and retinal cavernous hemangioma need to be excluded [15, 30, 31]. In patients with lesions covered with dense VH, mimickers including wet age-related macular degeneration (wAMD), proliferative diabetic retinopathy (PDR), retinal tear, and ischemic RVO should be ruled out before making a diagnosis [15, 32].


A wide range of treatment options for RAMs is available and has been reported in previous literature, including observation, laser photocoagulation, Nd: YAG laser membranotomy, anti-vascular endothelial growth factor (anti-VEGF) therapy, surgery, and tissue plasminogen activator (tPA) [32,33,34,35,36]. However, there is not yet a widely recognized treatment protocol. Moreover, treatment options should be tailored to the patients' specific conditions. Despite this, controllable risk factors including systemic hypertension, hypercholesterolemia, polycythemia, and arteriosclerotic cardiovascular disease must be controlled regardless of which management option is chosen.


It should be noted that a large part of RAMs are of no severe threat to vision and may regress spontaneously with a favorable prognosis [14, 32]. For asymptomatic patients without hemorrhages or exudations related to RAMs, a visit every six months until regression would suffice [4]. It is suggested that patients without macular involvement should be observed, and those with vision loss secondary to vitreous, intraretinal, or preretinal hemorrhages (macula not involved) may also be observed for spontaneous regression for a few months before the treatment [32, 37].

Laser photocoagulation

Laser photocoagulation has been used in the treatment of RAMs since the 1970s and has obtained satisfactory results [33, 38]. Both direct and indirect laser photocoagulation treatment can be used, especially when exudation or edema is vision-threatening. Direct laser photocoagulation is performed directly at the RAM, aiming to speed the regression of the RAM and fundamentally reduce the leakage [4]. As another option, indirect laser photocoagulation is applied to the surrounding retina of the RMA to order to keep the leakage away from the macula [33]. The main complications of laser photocoagulation are arteriolar occlusion, retinal traction, increased exudation, capillary dropout, and subretinal scarring [4, 39]. In recent years, subthreshold laser treatment (STLT) has been proposed to reduce the side effects of conventional laser photocoagulation [40, 41]. By reducing the duration of laser exposure and using sub-visible clinical endpoints, STLT can achieve similar treatment outcomes while reducing the complication rate when compared with conventional laser photocoagulation [40, 41].

Nd: YAG laser membranotomy

For sub-ILM hemorrhage secondary to RAM rupture, Nd: YAG laser membranotomy should be considered as a method for draining the sub-ILM hemorrhages into the vitreous for quicker absorption and has been proven to be both safe and effective [22]. It has been suggested that, once it is considered, Nd: YAG laser should be performed as early as possible because complete drainage is hard to achieve if the blood has become clotted [42]. Major complications of Nd: YAG laser include non-clearing VH, retinal detachment, macular hole, and ERM formation [43, 44].

Anti-VEGF therapy

Intravitreal anti-VEGF therapy for RAM treatment was first introduced in 2009 [36]. Since then, anti-VEGF therapy has been frequently studied as a promising treatment for RAMs with hemorrhage or macular edema. Anti-VEGF agents may close the involved pathologically permeabilized retinal arteries by normalizing the vessel walls and inducing thrombosis within the RAMs [11, 45]. Several previous studies indicate that anti-VEGF agents are an effective therapy for complicated hemorrhagic and/or exudative RAMs, resulting in quick and safe improvement of vision with fewer complications [11, 45, 46]. It has also been noted that combined laser and anti-VEGF therapy can rapidly reduce macular exudation by RAM [22]. However, the spontaneous nature of RAM regression may affect the reliability of the conclusions made in previous studies. A recently published study with a relatively large sample size compared the long-term treatment outcomes of hemorrhagic RAMs treated with anti-VEGF therapy or observation alone [12]. The findings were that there was no significant difference in the BCVA between the observation group and the anti-VEGF group [12]. Further studies are needed to fully reveal the influence of anti-VEGF therapy on VA. Although anti-VEGF agents were proven to be safe, the complications of intravitreal injections should be noted, including but not limited to endophthalmitis, VH, subconjunctival hemorrhage, retinal detachment, and retinal tear [47].

Pars plana vitrectomy

Although laser photocoagulation is a widely chosen treatment choice for RAMs, pars plana vitrectomy (PPV) should be considered in the following cases: (1) submacular hemorrhages that cannot be treated by laser photocoagulation; (2) non-clearing VHs after observation for over three months, as the natural resorption process usually lasts less than three months; (3) VHs that obscure the macula, making the diagnosis difficult, especially when other lesions are suspected; (4) VHs that interfere with necessary treatment needed for vision recovery; and (5) removal of pre-retinal hemorrhages if quicker vision recovery is needed [4, 32, 35, 37, 48]. In appropriate circumstances, PPV can help to remove the pre-retinal hemorrhages in a timely manner, reducing the toxic effects on the retina and reducing the probability of ERM formation [43, 48, 49]. Still, a substantial number of reported cases achieve satisfactory results with observation or laser, and the pros and cons must be fully weighed before performing PPV [30, 38, 50]. Complications associated with PPV include retinal tear, progression of cataracts, retinal detachment, and recurrent VH [35, 51].

tPA combined submacular surgery/pneumatic replacement

The combination of tPA with submacular surgery or pneumatic replacement has been effective in the treatment of submacular hemorrhage (SMH) [52,53,54]. Submacular surgery includes surgical drainage of the submacular hemorrhage through retinotomy, fluid-gas exchange, and insufflation with intravitreal gas [4, 53]. Pneumatic displacement is less invasive and includes perfluorocarbon gas injection and downward gaze positioning in order to remove the hemorrhage from the macula [54]. These two approaches both require patients to adopt a face-down position for several days after the operation. The prompt displacement of the SMH can reduce the macular damage caused by the hemorrhage and contribute to the effective recovery of VA [52]. Potential complications of pneumatic replacement include failure of displacement, VH, endophthalmitis, etc. Complications of submacular surgery are similar to those of PPV.

Case summary

This case is special, as the patient with RAM rupture suffered from multi-level hemorrhages likely due to a Valsalva effect related to constipation. She was under antiplatelet therapy and had nearly all of the aforementioned risk factors: female gender, old age, long-standing systemic hypertension, hypercholesterolemia, and arteriosclerotic cardiovascular disease. The combined effect of these risk factors had increased the susceptibility of her arterial walls. Usually, the blood pressure is supposed to be the lowest at night, when the patient was straining on the toilet, this caused her to experience greater blood pressure fluctuations during the Valsalva maneuver [55]. The rupture of the RAM occurred when the huge fluctuations in blood pressure hit her already fragile vessel walls. In this case, we initially opted for regular observation on her ocular condition because the blood had broken the ILM and flowed into the vitreous, equaling to an Nd: YAG laser membranotomy. At the same time, the relevant risk factors had also been strictly controlled by adjusting her oral drugs. After six weeks of observation, the majority of retinal hemorrhages had been absorbed, with marked improvement in her visual ability. Once the diagnosis of RAM rupture was established, direct laser photocoagulation was carefully performed at the RAM, which successfully accelerated the regression process (Figs. 2b and 3c). Three weeks after the laser photocoagulation, closure of the ruptured RAM was achieved, which was confirmed by FFA (Fig. 3b). The ERM and lamellar macular hole were noticed at her first visit and six weeks later, respectively. In addition, the lamellar macular hole was located exactly at the ILM breach in her previous visit, that is, at the junction of the VH and sub-ILM hemorrhage. We speculate that the local ILM at the edge of the lamellar macular hole was stretched and deformed due to the formation of the ERM. Coupled with the abnormal coagulation function of the patient, blood could easily pass through the deformed internal limiting membrane and thus drain into the vitreous cavity. This would be equivalent to the effect of an Nd: YAG laser membranotomy, which is also a special and interesting part of this case. Given that the patient's vision ability remained 20/40 for more than 8 months, surgery has not been considered for the time being. Furthermore, we will continue to observe this patient for a long time.


Overall, we have reported a rare case of a ruptured RAM and multi-level hemorrhages caused by the Valsalva maneuver in a patient with several risk factors. We have also offered a review of relevant literature on RAMs. This patient received observation and laser photocoagulation successively and obtained satisfactory results. However, it should be noted that the patient's ILM was broken at the time of presentation, protecting her from an Nd: YAG laser membranotomy. Furthermore, if the hemorrhage is trapped under the ILM, we recommend early Nd: YAG laser membranotomy in order to drain the hemorrhage into the vitreous cavity. Once the primary lesion is exposed, further treatment should be carried out according to the patient's condition. Moreover, we stress the need for treatment guidelines for RAMs and further research to assess the long-term safety and efficacy of different treatments for RAMs.

Availability of data and materials

All data and materials supporting our findings are contained within this manuscript.



Retinal artery macroaneurysms


Best-corrected visual acuity


Vitreous hemorrhage


Sub-inner limiting membrane


Color fundus photograph


Fundus fluorescein angiography


Indocyanine green angiography


Optical coherence tomography


Epiretinal membrane


Inner limiting membrane


Prothrombin time


Activated partial thrombin time


International normalized ratio




Retinal venous occlusion


Retinal arterial occlusion


Macular hole


Visual ability


Diabetic retinopathy


Idiopathic polypoidal choroidal vasculopathy


Choroidal neovascularization


Wet age-related macular degeneration


Proliferative diabetic retinopathy


Anti-vascular endothelial growth factor


Plasminogen activator


Subthreshold laser treatment


Pars plana vitrectomy


Submacular hemorrhage


  1. Pitkanen L, Tommila P, Kaarniranta K, Jaaskelainen JE, Kinnunen K. Retinal arterial macroaneurysms. Acta Ophthalmol. 2014;92(2):101–4.

    Article  PubMed  Google Scholar 

  2. Cahuzac A, Scemama C, Mauget-Faysse M, Sahel JA, Wolff B. Retinal arterial macroaneurysms: clinical, angiographic, and tomographic description and therapeutic management of a series of 14 cases. Eur J Ophthalmol. 2016;26(1):36–43.

    Article  PubMed  Google Scholar 

  3. Lavin MJ, Marsh RJ, Peart S, Rehman A. Retinal arterial macroaneurysms: a retrospective study of 40 patients. Br J Ophthalmol. 1987;71(11):817–25.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Speilburg AM, Klemencic SA. Ruptured retinal arterial macroaneurysm: diagnosis and management. J Optom. 2014;7(3):131–7.

    Article  PubMed  Google Scholar 

  5. Pstras L, Thomaseth K, Waniewski J, Balzani I, Bellavere F. The Valsalva manoeuvre: physiology and clinical examples. Acta Physiol (Oxf). 2016;217(2):103–19.

    Article  CAS  PubMed  Google Scholar 

  6. Ozcan SC, Kurtul BE, Ozarslan OD. Evaluation of microvascular changes in optic disc and retina by optical coherence tomography angiography during Valsalva maneuver. Int Ophthalmol. 2020;40(10):2743–9.

    Article  PubMed  Google Scholar 

  7. Chen T, Zheng H, Wang Y, Hu J, Chen C. Bilateral and multiple sub-internal limiting membrane hemorrhages in a familial retinal arteriolar tortuosity patient by Valsalva-like mechanism: an observational case report. BMC Ophthalmol. 2020;20(1):151.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Moosavi RA, Fong KC, Chopdar A. Retinal artery macroaneurysms: clinical and fluorescein angiographic features in 34 patients. Eye (Lond). 2006;20(9):1011–20.

    Article  CAS  PubMed  Google Scholar 

  9. Panton RW, Goldberg MF, Farber MD. Retinal arterial macroaneurysms: risk factors and natural history. Br J Ophthalmol. 1990;74(10):595–600.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Sakaguchi S, Muraoka Y, Kadomoto S, Ooto S, Murakami T, Nishigori N, et al. Three-dimensional locations of ruptured retinal arterial macroaneurysms and their associations with the visual prognosis. Sci Rep. 2022;12(1):503.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. Pichi F, Morara M, Torrazza C, Manzi G, Alkabes M, Balducci N, et al. Intravitreal bevacizumab for macular complications from retinal arterial macroaneurysms. Am J Ophthalmol. 2013;155(2):287-94 e1.

    Article  CAS  PubMed  Google Scholar 

  12. Kim JH, Kim JW, Kim CG, Lew YJ, Cho HJ. Influence of bevacizumab therapy and intraretinal hemorrhage in long-term outcomes of hemorrhagic retinal arterial macroaneurysm. Sci Rep. 2021;11(1):14246.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  13. Sonmez K, Ozturk F, Ozcan PY. Treatment of multilevel macular hemorrhage secondary to retinal arterial macroaneurysm with submacular tissue plasminogen activator. Eur J Ophthalmol. 2012;22(6):1026–31.

    Article  PubMed  Google Scholar 

  14. Rabb MF, Gagliano DA, Teske MP. Retinal arterial macroaneurysms. Surv Ophthalmol. 1988;33(2):73–96.

    Article  CAS  PubMed  Google Scholar 

  15. Aumiller MS, Rinehart J. Multi-layered haemorrhage secondary to retinal arterial macroaneurysm: a case report and review. Clin Exp Optom. 2015;98(2):117–21.

    Article  PubMed  Google Scholar 

  16. Goldenberg D, Soiberman U, Loewenstein A, Goldstein M. Heidelberg spectral-domain optical coherence tomographic findings in retinal artery macroaneurysm. Retina. 2012;32(5):990–5.

    Article  PubMed  Google Scholar 

  17. Wong T, Mitchell P. The eye in hypertension. The Lancet. 2007;369(9559):425–35.

    Article  Google Scholar 

  18. Cousins SW, Flynn HW Jr, Clarkson JG. Macroaneurysms associated with retinal branch vein occlusion. Am J Ophthalmol. 1990;109(5):567–70.

    Article  CAS  PubMed  Google Scholar 

  19. Sato R, Yasukawa T, Hirano Y, Ogura Y. Early-onset macular holes following ruptured retinal arterial macroaneurysms. Graefes Arch Clin Exp Ophthalmol. 2008;246(12):1779–82.

    Article  PubMed  Google Scholar 

  20. Pierre M, Mainguy A, Chatziralli I, Pakzad-Vaezi K, Ruiz-Medrano J, Bodaghi B, et al. Macular Hemorrhage Due to Age-Related Macular Degeneration or Retinal Arterial Macroaneurysm: Predictive Factors of Surgical Outcome. J Clin Med. 2021;10(24).

  21. Fraser-Bell S, Symes R, Vaze A. Hypertensive eye disease: a review. Clin Exp Ophthalmol. 2017;45(1):45–53.

    Article  PubMed  Google Scholar 

  22. Dedina L, Hassall MM, Anderson P. Ruptured Retinal Arterial Macroaneurysm. Asia Pac J Ophthalmol (Phila). 2021;10(1):129.

    Article  PubMed  Google Scholar 

  23. Cho WH, Chiang WY, Chen CH, Kuo HK. To treat or not to treat: a clinical series of retinal arterial macroaneurysms: a single-center retrospective study. Medicine (Baltimore). 2020;99(5):e19077.

    Article  CAS  PubMed  Google Scholar 

  24. Palestine AG, Robertson DM, Goldstein BG. Macroaneurysms of the Retinal Arteries. Am J Ophthalmol. 1982;93(2):164–71.

    Article  CAS  PubMed  Google Scholar 

  25. Chen KJ. Natural Course of Ruptured Retinal Arterial Macroaneurysm. Ophthalmol Retina. 2020;4(6):629.

    Article  PubMed  Google Scholar 

  26. Breazzano MP, Fernández-Avellaneda P, Freund KB. Swept-Source Optical Coherence Tomography Angiography of Retinal Arterial Macroaneurysm With Overlying Hemorrhage. JAMA Ophthalmol. 2019;137(4):e190247.

    Article  PubMed  Google Scholar 

  27. Territo JG, Rose SJ, Lindahl KJ. Spontaneous rupture of a macroaneurysm documented in real time during fluorescein angiography. Arch Ophthalmol. 2000;118(1):144–5.

    Article  CAS  PubMed  Google Scholar 

  28. Miura M, Muramatsu D, Hong YJ, Yasuno Y, Itami A, Iwasaki T, et al. Noninvasive vascular imaging of ruptured retinal arterial macroaneurysms by Doppler optical coherence tomography. BMC Ophthalmol. 2015;15:79.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  29. Spalter HF. Retinal macroaneurysms: a new masquerade syndrome. Trans Am Ophthalmol Soc. 1982;80:113–30.

    CAS  PubMed  PubMed Central  Google Scholar 

  30. Adamczyk DT, Olivares GE, Petito GT. Retinal arterial macroaneurysm: a longitudinal case study. J Am Optom Assoc. 1989;60(11):840–5.

    CAS  PubMed  Google Scholar 

  31. Lindgren GUN, SjÖDell L, Lindblom B. A Prospective Study of Dense Spontaneous Vitreous Hemorrhage. Am J Ophthalmol. 1995;119(4):458–65.

    Article  CAS  PubMed  Google Scholar 

  32. Kester E, Walker E. Retinal arterial macroaneurysm causing multilevel retinal hemorrhage. Optometry. 2009;80(8):425–30.

    Article  PubMed  Google Scholar 

  33. Hudomel J, Imre G. Photocoagulation treatment of solitary aneurysm near the macula lutea. Report of a case. Acta Ophthalmol (Copenh). 1973;51(5):633–8.

    Article  CAS  PubMed  Google Scholar 

  34. Chen YY, Lin LY, Chang PY, Chen FT, Mai ELC, Wang JK. Laser and Anti-Vascular Endothelial Growth Factor Agent Treatments for Retinal Arterial Macroaneurysm. Asia Pac J Ophthalmol (Phila). 2017;6(5):444–9.

    Article  CAS  PubMed  Google Scholar 

  35. Oie Y, Emi K. Surgical excision of retinal macroaneurysms with submacular hemorrhage. Jpn J Ophthalmol. 2006;50(6):550–3.

    Article  PubMed  Google Scholar 

  36. Gore DM, Thyagarajan S, Liasis A, Nischal KK. Functioning avascular retinae-a report of two siblings. Eye (Lond). 2009;23(2):491–3.

    Article  CAS  PubMed  Google Scholar 

  37. Evan Goldhagen B, Goldhardt R. Retinal Arterial Macroaneurysms: Updating your Memory on RAM Management. Curr Ophthalmol Rep. 2019;7(2):73–9.

    Article  PubMed  PubMed Central  Google Scholar 

  38. Godel V, Blumenthal M, Regenbogen L. Arterial macroaneurysm of the retina. Ophthalmologica. 1977;175(3):125–9.

    Article  CAS  PubMed  Google Scholar 

  39. Brown DM, Sobol WM, Folk JC, Weingeist TA. Retinal arteriolar macroaneurysms: long-term visual outcome. Br J Ophthalmol. 1994;78(7):534–8.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  40. Parodi MB, Iacono P, Ravalico G, Bandello F. Subthreshold laser treatment for retinal arterial macroaneurysm. Br J Ophthalmol. 2011;95(4):534–8.

    Article  PubMed  Google Scholar 

  41. Battaglia Parodi M, Iacono P, Pierro L, Papayannis A, Kontadakis S, Bandello FM. Subthreshold laser treatment versus threshold laser treatment for symptomatic retinal arterial macroaneurysm. Invest Ophthalmol Vis Sci. 2012;53(4):1783–6.

    Article  PubMed  Google Scholar 

  42. Chang PY, Wang JK, Yang CH. Spectral-domain optical coherence tomography findings of subinternal limiting membrane hemorrhage in the macula before and after Nd:YAG laser treatment. Taiwan J Ophthalmol. 2015;5(1):33–5.

    Article  PubMed  Google Scholar 

  43. Mennel S. Subhyaloidal and macular haemorrhage: localisation and treatment strategies. Br J Ophthalmol. 2007;91(7):850–2. Epub 2007/06/20.

    Article  PubMed  PubMed Central  Google Scholar 

  44. Ulbig MW, Mangouritsas G, Rothbacher HH, Hamilton AM, McHugh JD. Long-term results after drainage of premacular subhyaloid hemorrhage into the vitreous with a pulsed Nd:YAG laser. Arch Ophthalmol. 1998;116(11):1465–9.

    Article  CAS  PubMed  Google Scholar 

  45. Kadomoto S, Muraoka Y, Uji A, Ooto S, Murakami T, Tsujikawa A. Hemodynamic and structural changes in retinal arterial macroaneurysm after intravitreal anti-vascular endothelial growth factor injection. Am J Ophthalmol Case Rep. 2021;23:101182.

    Article  PubMed  PubMed Central  Google Scholar 

  46. Mansour AM, Foster RE, Gallego-Pinazo R, Moschos MM, Sisk RA, Chhablani J, Rojanaporn D, Sujirakul T, Arevalo JF, Lima LH, Wu L, Charbaji A, Saatci AO, Mansour HA, Martinez-Rubio C, Patel Y, Gangakhedkar S. Intravitreal anti-vascular endothelial growth factor injections for exudative retinal arterial macroaneurysms. Retina. 2019;39(6):1133–41.

    Article  CAS  PubMed  Google Scholar 

  47. Miller A, Wilneff MA, Yazji A, Petrinec E, Carbone M, Miller C, et al. Analysis of urgent follow up visits and complications after intravitreal injections: a retrospective cohort study. Int J Retina Vitreous. 2022;8(1):8.

    Article  PubMed  PubMed Central  Google Scholar 

  48. Wu TT, Chuang CT, Sheu SJ, Chiou YH. Non-vitrectomizing vitreous surgery for premacular haemorrhage. Acta Ophthalmol. 2011;89(2):194–7.

    Article  PubMed  Google Scholar 

  49. Gedik S, Gür S, Yilmaz G, Akova YA. Retinal arterial macroaneurysm rupture following fundus fluorescein angiography and treatment with Nd:YAG laser membranectomy. Ophthalmic Surg Lasers Imaging. 2007;38(2):154–6.

    Article  PubMed  Google Scholar 

  50. Maltsev DS, Kulikov AN, Uplanchiwar B, Lima LH, Chhablani J. Direct navigated laser photocoagulation as primary treatment for retinal arterial macroaneurysms. Int J Retina Vitreous. 2018;4:28.

    Article  PubMed  PubMed Central  Google Scholar 

  51. Recchia FM, Scott IU, Brown GC, Brown MM, Ho AC, Ip MS. Small-gauge pars plana vitrectomy: a report by the American Academy of Ophthalmology. Ophthalmology. 2010;117(9):1851–7.

    Article  PubMed  Google Scholar 

  52. Chew GWM, Ivanova T, Patton N, Dhawahir-Scala F, Jasani KM, Turner G, Charles S, Jalil A. STEP-WISE APPROACH TO THE MANAGEMENT OF SUBMACULAR HEMORRHAGE USING PNEUMATIC DISPLACEMENT AND VITRECTOMY: The Manchester Protocol. Retina. 2022;42(1):11–8.

    Article  PubMed  Google Scholar 

  53. Tan CS, Au Eong KG. Surgical drainage of submacular haemorrhage from ruptured retinal arterial macroaneurysm. Acta Ophthalmol Scand. 2005;83(2):240–1.

    Article  PubMed  Google Scholar 

  54. Abdelkader E, Yip KP, Cornish KS. Pneumatic displacement of submacular haemorrhage. Saudi J Ophthalmol. 2016;30(4):221–6.

    Article  PubMed  PubMed Central  Google Scholar 

  55. Cortes-Rios J, Rodriguez-Fernandez M. Circadian Rhythm of Blood Pressure of Dipper and Non-dipper Patients With Essential Hypertension: A Mathematical Modeling Approach. Front Physiol. 2020;11:536146.

    Article  PubMed  Google Scholar 

Download references


We would like to thank the subject in this study for advancing our understanding of retinal arterial macroaneurysms.


This research was funded by Fundamental Research Funds for the Central Universities, grant number 2042021kf0123. The funders had no role in the design of the study, data collection and analysis, interpretation of data, or in writing the manuscript.

Author information

Authors and Affiliations



Y.M., Z.Y., and C.C. collected the clinical information of the patient, and analyzed and interpreted the clinical data. Y.M. was a major contributor in writing the manuscript. Y.X. performed the laser photocoagulation. Y.M., L.L., and L.H. performed the fundus examinations. C.C. and Z.Y. reviewed and edited the manuscript. All authors read and approved the final manuscript.

Corresponding authors

Correspondence to Zuohuizi Yi or Changzheng Chen.

Ethics declarations

Ethics approval and consent to participate

The ethics approval was obtained from the Renmin Hospital of Wuhan University and all research was conducted according to the tenets of the Declaration of Helsinki. Written informed consent to participate was obtained from the patient’s daughter.

Consent for publication

Since the patient is illiterate, she provided verbal consent and her daughter signed a consent for publication of this case report and all the accompanying images.

Competing interests

The authors declare that they have no competing interests.

Additional information

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit The Creative Commons Public Domain Dedication waiver ( applies to the data made available in this article, unless otherwise stated in a credit line to the data.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Meng, Y., Xu, Y., Li, L. et al. Retinal arterial macroaneurysm rupture by Valsalva maneuver: a case report and literature review. BMC Ophthalmol 22, 461 (2022).

Download citation

  • Received:

  • Accepted:

  • Published:

  • DOI: