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  1. Retinal angiomatous proliferation (RAP) has been known as a variant of exudative age-related macular degeneration (AMD) with a unfavorable prognosis. To evaluate the effect of ranibizumab administered initiall...

    Authors: Young Gun Park and Young-Jung Roh
    Citation: BMC Ophthalmology 2015 15:182
    Content type: Research article Published on:

  2. Which of the choroidal layers suffers the most extensive morphological changes during the course of Vogt–Koyanagi–Harada (VKH) disease is still unknown. The aim of this study was to investigate the relationshi...

    Authors: Kiriko Hirooka, Wataru Saito, Kenichi Namba, Kazuomi Mizuuchi, Daiju Iwata, Yuki Hashimoto and Susumu Ishida
    Citation: BMC Ophthalmology 2015 15:181
    Content type: Research article Published on:

  3. The purpose of this study was to determine the clinical parameters related to metamorphopsia outcome in patients with resolved central serous chorioretinopathy (CSCR).

    Authors: Seokhyun Bae, Kiwon Jin, Hakyoung Kim and So Hyun Bae
    Citation: BMC Ophthalmology 2015 15:180
    Content type: Research article Published on:

  5. Although the mechanism of dry eye disease is not clearly understood, it is certain that inflammation and the immune response play a major role in determining the health of the ocular surface in dry eye patient...

    Authors: Kyung-Sun Na, Kyu-Yeon Hwang, Hyun-Soo Lee, So-Hyang Chung, Jee Won Mok and Choun-Ki Joo
    Citation: BMC Ophthalmology 2015 15(Suppl 1):159
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 15 Supplement 1

  6. Conjunctival and subconjunctival fibrogenesis and inflammation are sight compromising side effects that can occur subsequent to glaucoma filtration surgery. Despite initial declines in intraocular pressure res...

    Authors: Osamu Yamanaka, Ai Kitano-Izutani, Katsuo Tomoyose and Peter S. Reinach
    Citation: BMC Ophthalmology 2015 15(Suppl 1):157
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 15 Supplement 1

  7. Meibomian gland dysfunction (MGD) is the major cause of evaporative dry eye disease (EDED) and dysfunction is widely thought to mechanistically involve ductal hyperkeratinization, plugging and obstruction. Thi...

    Authors: James V. Jester, Geraint J. Parfitt and Donald J. Brown
    Citation: BMC Ophthalmology 2015 15(Suppl 1):156
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 15 Supplement 1

  8. Mesenchymal stem cells (MSC) have become a promising tool for cell therapy in regenerative medicine. They are readily available, demonstrate powerful differentiation capabilities and present immunosuppressive ...

    Authors: Liyun Zhang, Vivien Jane Coulson-Thomas, Tarsis Gesteira Ferreira and Winston W. Y. Kao
    Citation: BMC Ophthalmology 2015 15(Suppl 1):155
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 15 Supplement 1

  9. Mucins locate to the apical surfaces of all wet-surfaced epithelia including ocular surface. The functions of the mucins include anti-adhesive, lubrication, water retention, allergens and pathogen barrier func...

    Authors: Kumi Shirai and Shizuya Saika
    Citation: BMC Ophthalmology 2015 15(Suppl 1):154
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 15 Supplement 1

  10. Transient receptor potential (TRP) channels sense and transduce environmental stimuli into Ca2+ transients that in turn induce responses essential for cell function and adaptation. These non-selective channels wi...

    Authors: Peter S. Reinach, Stefan Mergler, Yuka Okada and Shizuya Saika
    Citation: BMC Ophthalmology 2015 15(Suppl 1):153
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 15 Supplement 1

  11. This review summarizes a recent finding regarding the intrinsic canonical Notch signaling pathway in regulating normal ocular surface morphogenesis and its role in the pathogenesis of goblet cell deficiency-as...

    Authors: Chia-Yang Liu
    Citation: BMC Ophthalmology 2015 15(Suppl 1):152
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 15 Supplement 1

  12. The primary goal of glaucoma treatment is to lower and control intraocular pressure (IOP) and thereby prevent functional deterioration. For glaucomas that are refractory to medical and incisional surgical ther...

    Authors: Dominik Bleisch, Sandra Furrer and Jens Funk
    Citation: BMC Ophthalmology 2015 15:179
    Content type: Research article Published on:

  13. The aim of this study was to evaluate the association between optic nerve head (ONH) parameters and branch retinal vein occlusion (BRVO) using spectral domain optical coherence tomography (SD-OCT).

    Authors: Andrea Szigeti, Miklós Schneider, Mónika Ecsedy, Zoltán Zs Nagy and Zsuzsanna Récsán
    Citation: BMC Ophthalmology 2015 15:178
    Content type: Research article Published on:

  14. Behçet’s disease (BD)-associated uveitis causes retinal damage leading to severe visual disturbance. The early morphological changes in the retina are revealed by disappearance or disruption of the external li...

    Authors: Masaru Takeuchi, Kozo Harimoto, Manzo Taguchi and Yutaka Sakurai
    Citation: BMC Ophthalmology 2015 15:177
    Content type: Case report Published on:

  15. Glaucoma is the leading cause of irreversible blindness worldwide. There tends to be a lower reporting of glaucoma in Africa compared to other blinding conditions in global burden data. Research findings of gl...

    Authors: Fatima Kyari, Gabriel Entekume, Mansur Rabiu, Paul Spry, Richard Wormald, Winifred Nolan, Gudlavalleti V. S. Murthy and Clare E. Gilbert
    Citation: BMC Ophthalmology 2015 15:176
    Content type: Research article Published on:

  16. Spectral-domain optical coherence tomography (SD-OCT) provides fast scan speed and high scan resolution improving its diagnostic accuracy. The purpose of this study was to evaluate if SD-OCT measurements and t...

    Authors: Lucia Tanga, Gloria Roberti, Francesco Oddone, Luciano Quaranta, Manuela Ferrazza, Francesca Berardo, Gianluca Manni and Marco Centofanti
    Citation: BMC Ophthalmology 2015 15:175
    Content type: Research article Published on:

  17. The effect of excess glucose on retinal cellular health remains controversial, and cellular reducing equivalents, as indicators of cellular energy production, are widely used as substitute indicators of retina...

    Authors: Christopher J. Layton
    Citation: BMC Ophthalmology 2015 15:174
    Content type: Research article Published on:

  18. One of the most challenging problems in vitro-retinal surgery is the recurrence of retinal detachment in the context of high-grade proliferative vitreoretinopathy (PVR). The aim of our retrospective study was ...

    Authors: Raffaele Mancino, Francesco Aiello, Elena Ciuffoletti, Emiliano Di Carlo, Angelica Cerulli and Carlo Nucci
    Citation: BMC Ophthalmology 2015 15:173
    Content type: Research article Published on:

  19. Glaucoma is a progressive disease responsible for the second commonest cause of blindness in the UK. Identifying appropriate patients for hospital care remains an ongoing challenge for all UK hospital glaucoma...

    Authors: Karim El-Assal, Jonathan Foulds, Stuart Dobson and Roshini Sanders
    Citation: BMC Ophthalmology 2015 15:172
    Content type: Research article Published on:

  20. Characteristic complications have been reported for transconjunctival sutureless vitrectomy, such as postoperative sclerotomy leakage and postoperative hypotony. Particular attention to sclerotomy closure is r...

    Authors: Hirotsugu Takashina, Akira Watanabe and Hiroshi Tsuneoka
    Citation: BMC Ophthalmology 2015 15:171
    Content type: Research article Published on:

  21. The opacification of hydrophilic intraocular lenses (IOLs) is a very rare complication in terms of absolute numbers. We report on the analyses of opacified Euromaxx ALI313Y and ALI313 IOLs (Argonoptics, German...

    Authors: Tamer Tandogan, Ramin Khoramnia, Chul Young Choi, Alexander Scheuerle, Martin Wenzel, Philipp Hugger and Gerd U. Auffarth
    Citation: BMC Ophthalmology 2015 15:170
    Content type: Research article Published on:

  22. Natural killer cell tumors can be broadly divided by origin into mature-cell and progenitor-cell types. The invasion of nasal-origin natural killer cells into the ophthalmologic field is sometimes observed in ...

    Authors: Kazuichi Maruyama, Hiroshi Kunikata, Sunao Sugita, Manabu Mochizuki, Ryo Ichinohasama and Toru Nakazawa
    Citation: BMC Ophthalmology 2015 15:169
    Content type: Case report Published on:

  25. Prostaglandin analogs reduce intraocular pressure (IOP) in patients with open-angle glaucoma or ocular hypertension; however, these medications may affect the ocular surface and elicit ocular discomfort when p...

    Authors: Joao F. Lopes, Douglas A. Hubatsch and Patricia Amaris
    Citation: BMC Ophthalmology 2015 15:166
    Content type: Research article Published on:

  26. Retinal detachment (RD) secondary to macular hole (MH) is a common complication in highly myopic eyes, usually leading to a poor visual prognosis. The purpose of this study was to evaluate the surgical outcome...

    Authors: Nan Hong, Bai-shuang Huang and Jian-ping Tong
    Citation: BMC Ophthalmology 2015 15:165
    Content type: Research article Published on:

  27. Vascular endothelial growth factor (VEGF) is thought to play an important role in the pathogenesis of diabetic retinopathy (DR). Previous studies have associated the VEGF rs2146323 polymorphism with the risk of D...

    Authors: Ying Zeng, Fangjie Dai, Ke Yang, Yongqing Tang, Meng Xu and Yiwu Zhou
    Citation: BMC Ophthalmology 2015 15:163
    Content type: Research article Published on:

  28. The latency and amplitude of visual evoked cortical responses are known to be affected by refractive states, suggesting that they may be used as an objective index of refractive errors. In order to establish a...

    Authors: Masaya Suzuki, Mizuki Nagae, Yuko Nagata, Naoya Kumagai, Koji Inui and Ryusuke Kakigi
    Citation: BMC Ophthalmology 2015 15:162
    Content type: Research article Published on:

  30. To evaluate vision-related quality of life in preoperative age-related cataract patients in China, using the Chinese version of the National Eye Institute Visual Function Questionnaire-25 (CHI-NEI-VFQ-25), tog...

    Authors: Min Zhu, Jiaming Yu, Jinsong Zhang, Qichang Yan and Yang Liu
    Citation: BMC Ophthalmology 2015 15:160
    Content type: Research article Published on:

  31. Posterior keratoconus is a rare cause of a corneal opacity in an infant. It is characterized by thinning of the posterior cornea without ectasia of the anterior cornea. Imaging of this condition with anterior ...

    Authors: Nisha Garg, Ta C. Chang, Bibiana Jin Reiser and Kara M. Cavuoto
    Citation: BMC Ophthalmology 2015 15:158
    Content type: Case report Published on:

  32. Intraocular foreign bodies (IOFBs) are an important cause of visual loss within the group of working age population. We aim to present the clinical features and the algorithm according to which we manage the f...

    Authors: Simona Delia Nicoară, Iulian Irimescu, Tudor Călinici and Cristina Cristian
    Citation: BMC Ophthalmology 2015 15:151
    Content type: Research article Published on:

  33. Dexamethasone intravitreal implant 0.7 mg (DEX 0.7) was approved for treatment of diabetic macular edema (DME) after demonstration of its efficacy and safety in the MEAD registration trials. We performed subgr...

    Authors: Albert J. Augustin, Baruch D. Kuppermann, Paolo Lanzetta, Anat Loewenstein, Xiao-Yan Li, Harry Cui, Yehia Hashad and Scott M. Whitcup
    Citation: BMC Ophthalmology 2015 15:150
    Content type: Research article Published on:

  35. We present a rare case of secondary angle closure glaucoma due to systemic lupus erythematosus choroidopathy as initial presentation of systemic lupus erythematosus, accompanied by central nervous system vascu...

    Authors: Young Soo Han, Chan min Yang, Sang-Hoon Lee, Jae Ho Shin, Sang Woong Moon and Ja Heon Kang
    Citation: BMC Ophthalmology 2015 15:148
    Content type: Case report Published on:

  36. Dry Eye Syndrome (DES) is a broad spectrum of uncomfortable ocular conditions that are caused by reduced production of tears or an increased tear evaporation rate. This study evaluated the relationship between...

    Authors: June-Hee Lee, Wanhyung Lee, Jin-Ha Yoon, Hongdeok Seok, Jaehoon Roh and Jong-Uk Won
    Citation: BMC Ophthalmology 2015 15:147
    Content type: Research article Published on:

  37. Previous studies described cases of Ocriplasmin injections in patients with vitreo-macular traction and reduced central visual acuity. We describe the first case of a patient with 20/20 visual acuity and vitre...

    Authors: Settimio Rossi, Ada Orrico, Paolo Melillo, Francesco Testa, Francesca Simonelli and Michele Della Corte
    Citation: BMC Ophthalmology 2015 15:146
    Content type: Case report Published on:

  38. Disc haemorrhage (DH) is considered a characteristic sign of glaucoma, but its causative mechanism remains to be determined. We present a case of DH that occurred in association with an enlarged peripapillary ...

    Authors: Kyoung Min Lee, Eun Ji Lee, Seung Hyen Lee and Tae-Woo Kim
    Citation: BMC Ophthalmology 2015 15:145
    Content type: Case report Published on:

  39. To compare outcomes of femtosecond laser-assisted deep anterior lamellar keratoplasty (FSL-DALK) and penetrating keratoplasty (FSL-PK) for the treatment of keratoconus.

    Authors: Yueqin Chen, Dan-Ning Hu, Yuan Xia, Liping Yang, Chunyan Xue and Zhenping Huang
    Citation: BMC Ophthalmology 2015 15:144
    Content type: Research article Published on:

  40. The ideal intraocular lens in cases of aphakia without capsular support is debated. Choices include anterior chamber lenses, iris- or scleral-sutured lenses, and iris-claw lenses. Our aim was to report our lon...

    Authors: Matteo Forlini, Wael Soliman, Adriana Bratu, Paolo Rossini, Gian Maria Cavallini and Cesare Forlini
    Citation: BMC Ophthalmology 2015 15:143
    Content type: Research article Published on:

  41. Sebaceous cell carcinoma of the eyelid is a malignant tumor. However, the pathoetiology of sebaceous cell carcinoma is not clear. Retinoic acid (RA) signaling is essential for skin epidermal differentiation in...

    Authors: Yueh-Ju Tsai, Shu-Ya Wu, Hsuan-Ying Huang, David Hui-Kang Ma, Nan-Kai Wang, Ching-Hsi Hsiao, Ching-Yi Cheng and Lung-Kun Yeh
    Citation: BMC Ophthalmology 2015 15:142
    Content type: Research article Published on:

  42. The aim of this study was to evaluate central corneal sensitivity after small incision lenticule extraction (SMILE) versus femtosecond laser-assisted laser in situ keratomileusis (FS-LASIK) for myopia.

    Authors: Miao He, Wenyong Huang and Xingwu Zhong
    Citation: BMC Ophthalmology 2015 15:141
    Content type: Research article Published on:

  43. Scleromalacia, in the form of scleral thinning, melting, and necrosis, is a potentially serious complication of pterygium excision. This study introduces a new biodegradable material, Ologenâ„¢ collagen matrix (...

    Authors: Chan-Ho Cho and Sang-Bumm Lee
    Citation: BMC Ophthalmology 2015 15:140
    Content type: Case report Published on:

  44. Peters anomaly is a rare developmental abnormality of the anterior segment of the eye and is one of the main causes of congenital corneal opacities. Typically, histopathology of Peters anomaly shows immature o...

    Authors: Wei Ni, Wei Wang, Jing Hong, Pei Zhang and Cong Liu
    Citation: BMC Ophthalmology 2015 15:139
    Content type: Case report Published on:

  46. Central retinal artery occlusion (CRAO) is an ocular emergency and most of the cases present with painless sudden persistent loss of vision in the range of counting fingers to perception of light. The presenta...

    Authors: Cheng-wei Lu, Jun Wang, Dan-dan Zhou, Ji-long Hao, Ling-ling Liang, Xiao-hong Li and Peng Hui
    Citation: BMC Ophthalmology 2015 15:137
    Content type: Case report Published on:

  47. We report changes of choroidal structure determined by binarization of enhanced depth imaging optical coherence tomographic (EDI-OCT) images after treatment for primary intraocular lymphoma (PIOL).

    Authors: Mariko Egawa, Yoshinori Mitamura, Hiroki Sano, Kei Akaiwa, Masanori Niki, Kentaro Semba, Shozo Sonoda and Taiji Sakamoto
    Citation: BMC Ophthalmology 2015 15:136
    Content type: Research article Published on:

  49. Dry eye disease (DED) affects millions of people worldwide. There are a variety of new treatments beyond traditional therapies such as preservative free artificial tears. Here, we conduct a survey to identify ...

    Authors: Aileen Sy, Kieran S. O’Brien, Margaret P. Liu, Puja A. Cuddapah, Nisha R. Acharya, Thomas M. Lietman and Jennifer Rose-Nussbaumer
    Citation: BMC Ophthalmology 2015 15:133
    Content type: Research article Published on:

  50. To investigate the molecular defects in a four-generation Chinese pedigree affected with Thiel-Behnke corneal dystrophy (TBCD). And to further study the relationship between genetic mutation and clinical manif...

    Authors: Yinhui Yu, Peijin Qiu, Yanan Zhu, Jinyu Li, Menghan Wu, Buyi Zhang and Ke Yao
    Citation: BMC Ophthalmology 2015 15:131
    Content type: Research article Published on:
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