Articles

Compound heterozygous missense mutations in a Chinese mucopolysaccharidosis type VI patient: a case report

Mucopolysaccharidosis type VI (MPS VI) is a rare autosomal recessive inherited disease caused by mutations in the arylsulfatase B (ARSB) gene. MPS VI is a multisystemic disease resulting from a deficiency in aryl...

Authors: Ming-Fang He, Ji Yang, Meng-Jie Dong, Yin-Ting Wang and Hai Liu

The population-based prevalence of trachomatous scarring in a trachoma hyperendemic setting: results from 152 impact surveys in Amhara, Ethiopia

Trachomatous scarring (TS) results from repeated infection with the bacterium Chlamydia trachomatis. Pronounced scarring is an underlying cause of trachomatous trichiasis (TT) that can lead to blindness. Since th...

Authors: Tigist Astale, Caleb D. Ebert, Andrew W. Nute, Mulat Zerihun, Demelash Gessese, Berhanu Melak, Eshetu Sata, Zebene Ayele, Gedefaw Ayenew, E. Kelly Callahan, Mahteme Haile, Taye Zeru, Zerihun Tadesse and Scott D. Nash

Recurrent dislocation of binocular crystal lenses in a patient with cystathionine beta-synthase deficiency

Ectopia lentis is the common ocular manifestation of homocystinuria resulting from cystathionine beta-synthase (CBS) deficiency which has a high risk of thromboembolic complications.

Authors: Ning Hua, Yuxian Ning, Hui Zheng, Ledong Zhao, Xuehan Qian, Charles Wormington and Jingyun Wang

Corneal nerve structure in patients with primary Sjögren’s syndrome in China

The aim of this study was to evaluate the in vivo confocal microscopic morphology of corneal subbasal nerves and its relationship with clinical parameters in patients with primary Sjögren’s syndrome in China.

Authors: Fangting Li, Qin Zhang, Xin Ying, Jing He, Yuebo Jin, Huiwen Xu, Yaobin Cheng and Mingwei Zhao

Ophthalmic emergency-room visits during the Covid-19 pandemic – a comparative study

The goal of this study is to compare ophthalmic emergency room (OER) visits during the Coronavirus disease-19 (Covid-19) pandemic to those during a control period.

Authors: Veronika Yehezkeli, Ygal Rotenstreich, Liron Naftali Ben Haim, Ifat Sher, Asaf Achiron and Avner Belkin

Evaluation of optical coherence tomography angiography parameters in patients treated with Hydroxychloroquine

One of the major side effects of Hydroxychloroquine (HCQ) is retinopathy. The aim of this study was to evaluate the Optical coherence tomography angiography (OCTA) parameters in a group of patients who have Hy...

Authors: Mohammadreza Akhlaghi, Farzan Kianersi, Hamed Radmehr, Alireza Dehghani, Afsaneh Naderi Beni and Pegah Noorshargh

Retro-orbital injection of FITC-dextran combined with isolectin B4 in assessing the retinal neovascularization defect

A reliable and effective method is required to deliver agent that can aid the in vivo imaging of retinal vessels. The aim of the present study was to evaluate retro-orbital (RO) injection of fluorescein-labele...

Authors: Jizhu Li, Yuqing Wu, Bingqian Liu, Ying Huang, Qingxiu Wu, Haichun Li, Sainan Xiao, Ying Lin and Tao Li

Characteristics and recurrence of pterygium in Saudi Arabia: a single center study with a long follow‐up

This study described the clinical features of patients with pterygium and analyzed the recurrence rate of conjunctival autografting alone, conjunctival autografting combined with intraoperative mitomycin C, an...

Authors: Waleed Alsarhani, Saeed Alshahrani, Mahmood Showail, Nawaf Alhabdan, Osama Alsumari, Abdullah Almalki, Abdulaziz Alsarhani, Adel Alluhaidan and Bader Alqahtani

Modeling the impact of COVID-19 on Retina Clinic Performance

COVID-19, a highly contagious respiratory virus, presents unique challenges to ophthalmology practice as a high-volume, office-based specialty. In response to the COVID-19 pandemic, many operational changes we...

Authors: Karan Sethi, Emily S. Levine, Shiyoung Roh, Jeffrey L. Marx and David J. Ramsey

Correction to: Panretinal photocoagulation after or prior to intravitreal conbercept injection for diabetic macular edema: a retrospective study

Authors: Wei Zhang, Guiyang Zhao, Weijie Fan and Taihong Zhao

Multimodal imaging of bilateral ischemic retinal vasculopathy associated with Berger’s IgA nephropathy: case report

Berger’s IgA nephropathy (IgAN) is the most common primary glomerulonephritis. However, some rare cases of retinal manifestations have been described, with only two cases of retinal vasculopathy reported in th...

Authors: Khaled El Matri, Francesca Amoroso, Olivia Zambrowski, Alexandra Miere and Eric H. Souied

Clinical differences between toric intraocular lens (IOL) and monofocal intraocular lens (IOL) implantation when myopia is determined as target refraction

The aim of this study is to analyze and compare the clinical results of toric intraocular lens (IOL) and monofocal IOL implantation when the target refraction value is -3 diopter (D) in cataract patients with ...

Authors: Da Young Shin, Ho Sik Hwang, Hyun Seung Kim, Man Soo Kim and Eun Chul Kim

Prediction of postoperative refractive astigmatism before toric intraocular lens implantation

To determine the preoperative factors influencing refractive astigmatism after cataract surgery for astigmatism correction by toric intraocular lens (IOL) implantation and to evaluate the prediction model usin...

Authors: Atsushi Kawahara

The response of anti-VEGF therapy and tamoxifen withdrawal of tamoxifen-induced cystoid macular edema in the same patient

Numerous cases with ocular toxicity secondary to tamoxifen have been reported, and became more apparent with keratopathy, cataract, optic neuritis, macular holes, crystalline retinopathy with or without cystoi...

Authors: Chuanyu Li, Jun Xiao, He Zou, Bo Yang and Lifu Luo

Impact of photoreceptor density in a 3D simulation of panretinal laser photocoagulation

During panretinal photocoagulation (PRP), the outer retina, especially the photoreceptors, are destroyed. During such procedures, the impact of the retinal photocoagulation, which is performed in the same phot...

Authors: Kentaro Nishida, Shizuka Takahashi, Hirokazu Sakaguchi, Shigeru Sato, Masanori Kanai, Akihiko Shiraki, Taku Wakabayashi, Chikako Hara, Yoko Fukushima, Susumu Sakimoto, Kaori Sayanagi, Ryo Kawasaki and Kohji Nishida

Short‐term changes in and preoperative factors affecting vaulting after posterior chamber phakic Implantable Collamer Lens implantation

To describe the very early vault changes in the first month after Implantable Collamer Lens (ICL) implantation and to evaluate the effect of preoperative biometric factors on vault.

Authors: Qiu-Jian Zhu, Wen-Jing Chen, Wei-Jian Zhu, Hai-Xiang Xiao, Man-Hui Zhu, Lie Ma, You Yuan and E. Song

Intraocular pressure changes after phacoemulsification in pseudoexfoliation versus healthy eyes

Pseudoexfoliation (PXF) syndrome is the most common cause of secondary glaucoma worldwide. This systemic disorder causes further damage to the optic nerve and ultimately increases the need for surgical interve...

Authors: Farshid Ramezani, Mohammad Nazarian and Leila Rezaei

Laboratory analysis and ray visualization of diffractive optics with enhanced intermediate vision

To assess the optical behavior of a new diffractive intraocular lens (IOL) and compare its performance to that of an established extended-depth-of-focus (EDOF) IOL.

Authors: Hyeck-Soo Son, Grzegorz Łabuz, Ramin Khoramnia, Timur M. Yildirim and Gerd U. Auffarth

Parsplana vitrectomy alone versus parsplana vitrectomy combined with phacoemulsification for the treatment of rhegmatogenous retinal detachment: a randomized study

To compare parsplana vitrectomy (PPV) with and without phacoemulsification to treat rhegmatogenous retinal detachment (RRD).

Authors: Paolo Mora, Stefania Favilla, Giacomo Calzetti, Giulia Berselli, Lucia Benatti, Arturo Carta, Stefano Gandolfi and Salvatore A. Tedesco

Sympathetic ophthalmia after 27-G pars plana vitrectomy

Sympathetic ophthalmia (SO) is a bilateral diffuse uveitis that can arise after ocular trauma or ocular surgery in the inciting eye. Pars plana vitrectomy (PPV) is one of the risk factors for SO. Several repor...

Authors: Yasuyuki Takai, Yoshihito Sakanishi, Masahiro Okamoto and Nobuyuki Ebihara

Diagnosis of cytomegalovirus corneal endotheliitis using surgically removed Descemet’s membrane and endothelium despite negative results with aqueous humor PCR: a case report

Cytomegalovirus (CMV) has been known to cause unilateral corneal endotheliitis with keratic precipitates and localized corneal edema, iridocyclitis, and secondary glaucoma. CMV endotheliitis is diagnosed based...

Authors: Suguru Nakagawa, Hitoha Ishii, Mitsuko Takamoto, Toshikatsu Kaburaki, Kiyoshi Ishii and Takashi Miyai

Flow cytometric analysis of T lymphocytes and cytokines in aqueous humor of patients with varicella zoster virus-mediated acute retinal necrosis

The purpose of this study is to investigate the aqueous humor (AH) T lymphocyte subsets and cytokines of acute retinal necrosis (ARN) to elucidate the immunologic inflammatory features of this disorder.

Authors: Hao Kang, Yunbo Wei, Ming Liu, Di Yu and Yong Tao

Ultra-wide field swept-source optical coherence tomography angiography in patients with diabetes without clinically detectable retinopathy

To investigate alterations in retinal microvasculature in eyes with preclinical diabetic retinopathy (DR) using ultra-wide field swept-source optical coherence tomography angiography (UWF SS OCTA).

Authors: Jingyuan Yang, Bilei Zhang, Erqian Wang, Song Xia and Youxin Chen

USH2A gene variants cause Keratoconus and Usher syndrome phenotypes in Pakistani families

Retinitis pigmentosa (RP) is the most common inherited retinal dystrophy, affecting approximately 1 in 4000 individuals worldwide. The most common form of syndromic RP is Usher syndrome (USH) accounting for ap...

Authors: Asif Naveed Ahmed, Raheel Tahir, Niamat Khan, Mushtaq Ahmad, Muhammad Dawood, Abdul Basit, Muhammad Yasin, Maha Nowshid, Muhammad Marwan, Komal Sultan and Shamim Saleha

Epiretinal membrane appearance or progression after intravitreal injection in age-related macular degeneration

The purpose of this study is to evaluate the influence of anti-vascular endothelial growth factor (VEGF) in the appearance or progression of epiretinal membranes (ERMs) in age-related macular degeneration (ARM...

Authors: Hikari Taniguchi, Izumi Yoshida, Masashi Sakamoto and Takatoshi Maeno

Orbital migration of schistosome eggs: a case report

Ocular damage, including damage to the conjunctiva, lacrimal gland, eyelids, and orbit, caused by Schistosoma haematobium is sporadic. We report a clinical case of orbital migration of schistosome eggs.

Authors: Nouhoum Guirou, Serge Resnikoff, Abba Kaka Hadja Yakoura, Michel Gouda, Seydou Bakayoko, Abdoulaye Napo, Rodrigue Romulad Elien, Robert Della Rocca, Fatoumata Sylla and Lamine Traoré

Comparison of 5-year outcomes between trabeculectomy combined with phacoemulsification and trabeculectomy followed by phacoemulsification: a retrospective cohort study

We aimed to compare the outcomes of trabeculectomy combined with phacoemulsification and those of trabeculectomy followed by phacoemulsification.

Authors: Shogo Arimura, Kentaro Iwasaki, Yusuke Orii, Yoshihiro Takamura and Masaru Inatani

Intra- and interobserver concordance of a new classification system for myopic maculopathy

Myopic maculopathy (MM) is one of the major causes of visual impairment and irreversible blindness in eyes with pathologic myopia (PM). However, the classification of each type of lesion associated with MM has...

Authors: Rong-rong Zhang, Yan Yu, Yin-fen Hou and Chang-fan Wu

Incidence and management of retrobulbar hemorrhage after blowout fracture repair

Retrobulbar hemorrhage (RBH) is a rare complication after orbital surgery but associated with ocular complications including blindness. The aim of this study was to identify clinical characteristics of patient...

Authors: Jae Hwi Park, Inhye Kim and Jun Hyuk Son

Profile of central corneal thickness and corneal endothelial cell morpho-density in healthy Congolese eyes

To determine the pachymetric and corneal endothelial cell morphometric features and their relationship to ocular and systemic factors in healthy Congolese subjects.

Authors: Joseph-Theodore K. Kelekele, David L. Kayembe and Jean-Claude Mwanza

Modified superior oblique intrasheath tenectomy in A-pattern with superior oblique overaction

To evaluate the effect of modified superior oblique intrasheath tenectomy (MSOIT) on superior oblique overaction (SOOA) with A-pattern.

Authors: Chunhua Sun, Ze Wang and Bo Xia

Gender differences in refraction prediction error of five formulas for cataract surgery

To evaluate gender differences in optical biometry measurements and lens power calculations.

Authors: Yibing Zhang, Tingyang Li, Aparna Reddy and Nambi Nallasamy

Dacryoendoscopy-assisted incision of Hasner’s valve under nasoendoscopy for membranous congenital nasolacrimal duct obstruction after probing failure: a retrospective study

To introduce a treatment option: dacryoendoscopy-assisted incision of Hasner’s valve under nasoendoscopy and assess its efficacy in treating membranous congenital nasolacrimal duct obstruction (CNLDO) in child...

Authors: Yue Li, Min Wei, Xueru Liu, Leilei Zhang, Xuefei Song and Caiwen Xiao

Early clinical outcomes and comparison between trans-PRK and PRK, regarding refractive outcome, wound healing, pain intensity and visual recovery time in a real‐world setup

To compare early clinical outcomes of single-step transepithelial photorefractive keratectomy (tPRK) and photorefractive keratectomy (PRK) regarding refractive outcome, visual acuity, wound healing, pain inten...

Authors: Harald C. Gaeckle

Intraoperative optical coherence tomography guided corneal sweeping for removal of remnant Interface fluid during ultra-thin Descemet stripping automated endothelial keratoplasty

Remnant interface fluid following Descemet stripping automated endothelial keratoplasty (DSAEK) is associated with postoperative detachments. The aim of this study was to assess outcomes of intraoperative opti...

Authors: Michael Mimouni, Martin Kronschläger, Manuel Ruiss and Oliver Findl

Objective and subjective evaluation of trifocal diffractive intraocular Lens after cataract extraction with phacoemulsification: a prospective clinical study

This study aimed to assess visual outcomes, quality of vision and patients’ satisfaction of a trifocal diffractive intraocular lens after cataract surgery with phacoemulsification.

Authors: Ahmed A. Zein El-Dein, Ahmed Elmassry, Hazem M. El-Hennawi and Ehab F. Mossallam

Distribution of ocular biometric parameters and optimal model of anterior chamber depth regression in 28,709 adult cataract patients in China using swept‐source optical biometry

The purpose of this study was to evaluate the ocular biometric parameters in adult cataract patients from China and create an anterior chamber depth (ACD) regression model.

Authors: Qiong Lei, Haixia Tu, Xi Feng, Julio Ortega-Usobiaga, Danmin Cao and Yong Wang

Traumatic displacement of laser in situ keratomileusis flaps: an integrated clinical case presentation

Traumatic dislocation of laser-assisted in situ keratomileusis (LASIK) corneal flaps is an uncommon postoperative complication that could occur any time after LASIK, and could be visually devastating. We evalu...

Authors: Lu-Yang Shih, Kai-Ling Peng and Jiunn-Liang Chen

A new radiological measurement method used to evaluate the modified transconjunctival orbital fat decompression surgery

A new radiological method was used to evaluate the plastic effect of modified transconjunctival orbital fat decompression surgery in patients with inactive thyroid-associated ophthalmopathy.

Authors: Bei Li, Li Feng, Huamin Tang, Liuzhi Zeng and Wei Lin

Effects of lid debris debridement combined with meibomian gland expression on the ocular surface MMP-9 levels and clinical outcomes in moderate and severe meibomian gland dysfunction

To evaluate the effects of lid debris debridement and meibomian gland expression (MGX) on extracellular matrix metalloproteinase-9 (MMP-9) levels and clinical outcomes of moderate and severe MGD.

Authors: Su Young Moon, Sol Ah Han, Hye Ji Kwon, So Young Park, Jae Hyuck Lee, Ho Seok Chung, Jae Yong Kim, Hungwon Tchah and Hun Lee

Comparative study of combined vitrectomy with phacoemulsification versus vitrectomy alone for primary full-thickness macular hole repair

To assess the effectiveness and safety of 23-gauge pars plana vitrectomy combined with phacoemulsification versus vitrectomy alone in patients over 50 years with primary full-thickness macular holes (FTMH).

Authors: Christophe Valmaggia, Filip Kostadinov, Corina Lang and Josef Guber

Prognostic factors and epidemiology of adult open globe injuries from Western Sydney: a twelve-year review

To identify prognostic factors determining final visual outcome following open globe injuries.

Authors: Haochi Ho, Jane Foo, Yi-Chiao Li, Samantha Bobba, Christopher Go, Jaya Chandra and Adrian T. Fung

Long-term ocular biometric variations after scleral buckling surgery in macula-on rhegmatogenous retinal detachment

Myopic shift and biometric ocular changes have been previously observed after scleral buckling (SB) surgery in rhegmatogenous retinal detachment (RRD), but long term-term outcomes had not yet been explored. Th...

Authors: Giuseppe Maria Albanese, Alberto Cerini, Giacomo Visioli, Marco Marenco and Magda Gharbiya

Artisan versus Artiflex phakic intraocular lens implantation in the treatment of moderate to high myopia: meta-analysis

To compare the postoperative safety, efficacy, predictability, visual quality and biomechanics after implantation of Artisan vs. Artiflex phakic intraocular lenses (PIOLs).

Authors: Chenting Hou, Hui Li, Jiangfeng Li, Jinjian Li, Hui Peng and Qing Wang

Macular vascular changes in pregnant women with gestational diabetes mellitus by optical coherence tomography angiography

Retinal capillary is vulnerable to diabetes, whether gestational diabetes mellitus (GDM) eyes without clinical retinopathy have capillary abnormalities has not been well studied. To observe the microvasculatur...

Authors: Guodong Liu and Fang Wang

A clinical decision model based on machine learning for ptosis

To establish a decision model based on two- (2D) and three-dimensional (3D) eye data of patients with ptosis for developing personalized surgery plans.

Authors: Xuefei Song, Weilin Tong, Chaoyu Lei, Jingxuan Huang, Xianqun Fan, Guangtao Zhai and Huifang Zhou

Targeted next generation sequencing and family survey enable correct genetic diagnosis in CRX associated macular dystrophy – a case report

We present 3 members of a family with macular dystrophy, originally diagnosed as Stargardt disease, with a significantly variable age at onset, caused by a heterozygous mutation in CRX.

Authors: Saoud Al-Khuzaei, Karl A. Z. Hudspith, Suzanne Broadgate, Morag E. Shanks, Penny Clouston, Andrea H. Németh, Stephanie Halford and Susan M. Downes

Restarting cataract surgery during the COVID-19 pandemic; a prospective study analysing 30 day outcomes after elective cataract surgery in the United Kingdom

Cataract is a significant cause of preventable blindness in the United Kingdom and worldwide. Prior to the COVID-19 pandemic, cataract surgery was the most commonly performed operation by the National Health S...

Authors: Francis Carr, Paras Agarwal, Harmehak Narula, Tiran S. Keragala, Samer Elshikh Hassan Awwad, Ahmed Roble and Vinod Gangwani

A data-driven approach for the discovery of biomarkers associated with thyroid eye disease

Thyroid eye disease (TED) is the most common autoimmune disease and usually occurs in patients with hyperthyroidism. In this disease, eye-related tissue, such as eye muscles, eyelids, tear glands, etc., become...

Authors: Huihui Zou, Weiwei Xu, Ying Wang and Zhihong Wang

Association of TGFB -509C>T promoter polymorphism with primary angle closure glaucoma in a North Indian Punjabi cohort

Transforming growth factor beta (TGFB) is an important candidate gene implicated in glaucoma pathogenesis because it affects retinal ganglionic cell survival. The present study assessed the genetic association of...

Authors: Nanamika Thakur, Rajeev Kumar Pandey, Rashim Mannan, Archna Pruthi and Sanjana Mehrotra