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  1. Macular holes (MHs) are one of the complications of posterior uveitis that can significantly disturb vision. Conventional MH surgery (vitrectomy, internal limiting membrane (ILM) peeling, and gas tamponade) ha...

    Authors: Masayuki Hirano, Yuki Morizane, Tetsuhiro Kawata, Shuhei Kimura, Mio Hosokawa, Yusuke Shiode, Shinichiro Doi, Mika Hosogi, Atsushi Fujiwara and Fumio Shiraga
    Citation: BMC Ophthalmology 2015 15:83
    Content type: Case report Published on:

  3. Patient-centered care recognizes the obligation to understand and meet patient’s expectations. An individual’s satisfaction has been found to affect health-related decisions and treatment-related behaviours, w...

    Authors: Cheryl Pui-Yan Au, Nicole Fardell, Maria Williams, Samantha Fraser-Bell, Anna Campain and Mark Gillies
    Citation: BMC Ophthalmology 2015 15:80
    Content type: Research article Published on:

  5. Corneal cross-linking is widely used to treat keratoconus. However, to date, only limited data from randomized trials support its efficacy.

    Authors: Stefan J. Lang, Elisabeth M. Messmer, Gerd Geerling, Marc J. Mackert, Tobias Brunner, Sylvia Dollak, Borislav Kutchoukov, Daniel Böhringer, Thomas Reinhard and Philip Maier
    Citation: BMC Ophthalmology 2015 15:78
    Content type: Research article Published on:

  6. Conjunctival amyloidosis is a very rare condition, generally unilateral, and presents mostly as an isolated condition without systemic compromise. Our purpose is to present a new case of systemic amyloidosis w...

    Authors: Leandro J. Correa, J. Pablo Maccio, Evangelina Esposito, Rodolfo Monti, M. Eugenia Gonzalez-Castellanos, Martin Paradelo, Horacio M. Serra and Julio A. Urrets-Zavalia
    Citation: BMC Ophthalmology 2015 15:77
    Content type: Case report Published on:

  7. Hsf4 is closely related to the development of cataract. However, the molecular mechanisms remain unknown. This study aimed to explore the molecular mechanisms that how Hsf4 mutations influence development of l...

    Authors: Wenjuan Zhao, Wenqing Zhao, Jun Zhao, Dong Wang and Jinghai Li
    Citation: BMC Ophthalmology 2015 15:76
    Content type: Research article Published on:

  9. Aberrant dark adaptation is common to many ocular diseases and pathophysiological conditions, including vitamin A deficiency, cardiopulmonary diseases, and hypoxia. Scotopic vision and pupillary responsiveness...

    Authors: Alain B. Labrique, Amanda C. Palmer, Katherine Healy, Sucheta Mehra, Theodor C. Sauer, Keith P. West Jr and Alfred Sommer
    Citation: BMC Ophthalmology 2015 15:74
    Content type: Technical advance Published on:

  10. Due to its high prevalence and associated sight-threatening pathologies, myopia has emerged as a major health issue in East Asia. The purpose was to test the impact on myopia development of a school-based inte...

    Authors: Ju-Xiang Jin, Wen-Juan Hua, Xuan Jiang, Xiao-Yan Wu, Ji-Wen Yang, Guo-Peng Gao, Yun Fang, Chen-Lu Pei, Song Wang, Jie-Zheng Zhang, Li-Ming Tao and Fang-Biao Tao
    Citation: BMC Ophthalmology 2015 15:73
    Content type: Research article Published on:

  11. Intracameral cefuroxime is recommended as prophylaxis against postoperative endophthalmitis (POE) following cataract surgery. Aprokam is the only licensed product for prophylaxis of POE, although unlicensed in...

    Authors: Christine Purslow, Keith Davey, Mildred Johnson, Guilhem Pietri and Gaurav Suri
    Citation: BMC Ophthalmology 2015 15:72
    Content type: Research article Published on:

  12. The effectiveness of ranibizumab in the treatment of diabetic macular edema has been proven with large clinical trials. For bevacizumab only two clinical trials have been published and a head-to-head compariso...

    Authors: A.M.E. Schauwvlieghe, G. Dijkman, J.M. Hooymans, F.D. Verbraak, C.B. Hoyng, M.G.W. Dijkgraaf, R. Van Leeuwen, J.R. Vingerling, A.C. Moll and Reinier O. Schlingemann
    Citation: BMC Ophthalmology 2015 15:71
    Content type: Study protocol Published on:

  14. There seems a preponderance of hospital-based studies on the prevalence of Allergic Conjunctivitis (AC) compared to community-based ones, particularly among children in Ghana and Africa as a whole. Meanwhile, ...

    Authors: David Ben Kumah, Seth Yaw Lartey, Felix Yemanyi, Evans Gyimah Boateng and Emmanuel Awuah
    Citation: BMC Ophthalmology 2015 15:69
    Content type: Research article Published on:

  15. The aim of this retrospective study was to evaluate the course of dry eye syndrome after phacoemulsification surgery.

    Authors: Servet Cetinkaya, Emine Mestan, Nursen Oncel Acir, Yasemin Fatma Cetinkaya, Zeynep Dadaci and Halil Ibrahim Yener
    Citation: BMC Ophthalmology 2015 15:68
    Content type: Research article Published on:

  16. Recently there has been a great deal of new population based evidence on visual impairment generated in sub-Saharan Africa (SSA), thanks to the Rapid Assessment of Avoidable Blindness (RAAB) survey methodology...

    Authors: Susan Lewallen, Elena Schmidt, Emma Jolley, Robert Lindfield, William H. Dean, Colin Cook, Wanjiku Mathenge and Paul Courtright
    Citation: BMC Ophthalmology 2015 15:67
    Content type: Research article Published on:

  17. To evaluate the efficacy and safety of half-dose photodynamic therapy (PDT combined with ranibizumab for polypoidal choroidal vasculopathy (PCV). PCV is commonly treated with a combination of anti-vascular end...

    Authors: Ian Y. Wong, Xuan Shi, Rita Gangwani, Paul Zhao, Lawrence P. Iu, Qing Li, Alex Ng and Xiaoxin Li
    Citation: BMC Ophthalmology 2015 15:66
    Content type: Research article Published on:

  19. Previous studies demonstrate changes of autoantibody concentrations against retinal and optic nerve head antigens in the serum of glaucoma patients in comparison to healthy persons. These antibodies belong to ...

    Authors: Katharina Bell, Corina Wilding, Sebastian Funke, Norbert Pfeiffer and Franz H. Grus
    Citation: BMC Ophthalmology 2015 15:64
    Content type: Research article Published on:

  21. we conducted our meta-analysis of published studies to assess existing evidence about the efficacy and safety of vitrectomy with ILM peeling vs. that of vitrectomy with no ILM peeling for Macular hole-induced ...

    Authors: Jing Su, Xinquan Liu, Lijun Zheng and Hongping Cui
    Citation: BMC Ophthalmology 2015 15:62
    Content type: Research article Published on:

  23. Iris vascular tufts are rare iris stromal vascular hamartomas. Patients with iris vascular tufts generally remain asymptomatic until presenting with a spontaneous hyphaema or with mild intraoperative pupil mar...

    Authors: Kenneth G. J. Ooi, Rohan Gupta, Sarah B. Wang, Samuel Dance, Armand Borovik and Ian C. Francis
    Citation: BMC Ophthalmology 2015 15:60
    Content type: Case report Published on:

  25. Rebamipide with mucin secretagogue activity was recently approved for the treatment of dry eye. The efficacy and safety in the treatment of rebamipide were shown in two pivotal clinical trials. It was the aim ...

    Authors: Kaori Ueda, Wataru Matsumiya, Keiko Otsuka, Yoshifumi Maeda, Takayuki Nagai and Makoto Nakamura
    Citation: BMC Ophthalmology 2015 15:58
    Content type: Research article Published on:

  26. Tumor necrosis factor-alpha inhibitors are widely used agents in the treatment of immune disorders such as rheumatoid arthritis and inflammatory bowel disease. Despite their anti-inflammatory action, paradoxic...

    Authors: Alexandre Matet, Alejandra Daruich, Talal Beydoun, Jacques Cosnes and Jean-Louis Bourges
    Citation: BMC Ophthalmology 2015 15:57
    Content type: Case report Published on:

  28. Fungal keratitis is a kind of intractable and sight-threatening diseases. Spleen-tyrosine kinase (Syk) is a non-receptor tyrosine kinase, which plays an important role in the signaling pathway of the receptors...

    Authors: Ying Liu, Guiqiu Zhao, Jing Lin, Cui Li, Qing Li, Chengye Che, Qian Wang and Liting Hu
    Citation: BMC Ophthalmology 2015 15:55
    Content type: Research article Published on:

  29. Brimonidine is a highly selective α2 adrenergic agonist that has been widely used in anti-glaucoma eyedrops. The aim of this study was to investigate its putative anti-fibrotic role in the fibrosis caused by acti...

    Authors: Samin Hong, Sueng-Han Han, Chan Yun Kim, Kang Yoon Kim, Yoo Kyung Song and Gong Je Seong
    Citation: BMC Ophthalmology 2015 15:54
    Content type: Research article Published on:

  30. Tear lipid morphology is important for normal tear function. Recently, there have been clinical studies using interferometry to assess lipid layer thickness (LLT). The aim of the study is to examine the repeat...

    Authors: Yang Zhao, Carin Lay San Tan and Louis Tong
    Citation: BMC Ophthalmology 2015 15:53
    Content type: Research article Published on:

  31. This was an indirect comparison of the effectiveness of intravitreal aflibercept (IVT-AFL) 2 mg every 8 weeks after 5 initial monthly doses (or if different periods, after an initial monthly dosing period) (2q...

    Authors: Jean-Francois Korobelnik, Jos Kleijnen, Shona H Lang, Richard Birnie, Regina M Leadley, Kate Misso, Gill Worthy, Dominic Muston and Diana V Do
    Citation: BMC Ophthalmology 2015 15:52
    Content type: Research article Published on:

  32. Tolosa-Hunt syndrome is a rare clinical syndrome characterized by painful ophthalmoplegia and ipsilateral cranial neuropathies. It is caused by an inflammatory process of unknown etiology.

    Authors: Tarek A Shazly, Ellen B Mitchell, Gabrielle R Bonhomme and Joel S Schuman
    Citation: BMC Ophthalmology 2015 15:51
    Content type: Case report Published on:

  35. Primary extranodal marginal zone lymphoma (EMZL) of the uvea is a rare condition and diagnosis may be challenging. We aim to report the clinical, histopathologic and immunohistochemical findings in a case of p...

    Authors: Xinxiao Gao, Bin Li, Qisheng You and Xiaoyan Peng
    Citation: BMC Ophthalmology 2015 15:48
    Content type: Case report Published on:

  36. Intraorbital haematoma is a rare clinical entity which can be caused by orbital traumas, neoplasms, surgeries nearby sinuses and orbit, vascular malformations, acute sinusitis, systemic abnormalities, barotrau...

    Authors: Alper Mete, Can Pamukcu, Ahmet Mete, Sabit Kimyon, Duçem Mete, İbrahim Gözen and Oğuzhan Saygılı
    Citation: BMC Ophthalmology 2015 15:47
    Content type: Case report Published on:

  37. Diabetic retinopathy (DR) is one of the leading causes of blindness in adults in industrialized countries and the emerging cause of blindness in developing countries. The objective of this study was to describ...

    Authors: Aida Giloyan, Tsovinar Harutyunyan and Varduhi Petrosyan
    Citation: BMC Ophthalmology 2015 15:46
    Content type: Research article Published on:

  38. Results of ocular biometric measurements in retinal vein occlusion (RVO) eyes are still inconclusive and controversial. The aim of this study was to evaluate the association between ocular axial length (AL), v...

    Authors: Andrea Szigeti, Miklós Schneider, Mónika Ecsedy, Zoltán Zsolt Nagy and Zsuzsanna Récsán
    Citation: BMC Ophthalmology 2015 15:45
    Content type: Research article Published on:

  39. Cystoid macular edema (CME) in retinitis pigmentosa (RP) has been managed in several ways as documented in the literature, with little success, though. The aim of our study was to report for the first time in ...

    Authors: Giannis-Aimant Moustafa and Marilita M Moschos
    Citation: BMC Ophthalmology 2015 15:44
    Content type: Case report Published on:

  40. Drusen are important risk factor for neovascular age-related macular degeneration (AMD) and have a dynamic nature as they can enlarge, newly form, or disappear over time. There have been few reports on drusen ...

    Authors: Ji Hwan Lee, Taekjune Lee, Sung Chul Lee and Christopher Seungkyu Lee
    Citation: BMC Ophthalmology 2015 15:43
    Content type: Case report Published on:

  41. This objective of the review and analysis is to demonstrate that acyclovir (ACV) 3% ophthalmic ointment is superior to idoxuridine (IDU) in treating herpetic keratitis (HK) presenting as dendritic and geograph...

    Authors: Diane E Balderson, Gengqian Cai, Michael A Fries, David M Kleinman, Megan M McLaughlin, Trupti M Trivedi, John I Wurzelmann and Sheila B Young
    Citation: BMC Ophthalmology 2015 15:42
    Content type: Research article Published on:

  42. Previous studies suggest there are large variations in adherence of ophthalmologists with the American Academy of Ophthalmology’s Preferred Practice Patterns (PPPs). The purpose of this study was to compare ra...

    Authors: Nazlee Zebardast, Jason F Solus, Harry A Quigley, Divya Srikumaran and Pradeep Y Ramulu
    Citation: BMC Ophthalmology 2015 15:41
    Content type: Research article Published on:

  45. Sjogren’s syndrome (SS) is a chronic autoimmune disease mainly affecting salivary and lacrimal glands. Current diagnostic criteria for SS utilize anti-Ro and anti-La as serological markers. Animal models for S...

    Authors: Lakshmanan Suresh, Kishore Malyavantham, Long Shen and Julian L Ambrus Jr
    Citation: BMC Ophthalmology 2015 15:38
    Content type: Research article Published on:

  47. To assess repeatability (intra-observer variability) and reproducibility (inter-operator variability) of intraocular pressure (IOP) measurements with servo-controlled Bioresonator Applanation Resonance Tonomet...

    Authors: Laura Ottobelli, Paolo Fogagnolo, Paolo Frezzotti, Stefano De Cillà, Elena Vallenzasca, Maurizio Digiuni, Ruggiero Paderni, Ilaria Motolese, Simone Alex Bagaglia, Eduardo Motolese and Luca Rossetti
    Citation: BMC Ophthalmology 2015 15:36
    Content type: Research article Published on:

  48. The recurrence rate of periocular nodular basal cell carcinoma (PNBCC) following treatment with imiquimod (IMQ) has not yet been established. Previous studies did not include histological follow-up. The aim of...

    Authors: Erick Marcet Santiago de Macedo, Rachel Camargo Carneiro, Patricia Picciarelli de Lima, Breno Gonçalves Silva and Suzana Matayoshi
    Citation: BMC Ophthalmology 2015 15:35
    Content type: Research article Published on:

  49. Bacterial pathogens isolated from dacryocystitis patients are diverse and complex in terms of their distribution, prevalence, and antimicrobial susceptibility pattern. The clinical importance of microbial caus...

    Authors: Yared Assefa, Feleke Moges, Mengistu Endris, Banchamlak Zereay, Bemnet Amare, Damtew Bekele, Solomon Tesfaye, Andargachew Mulu and Yeshambel Belyhun
    Citation: BMC Ophthalmology 2015 15:34
    Content type: Research article Published on:

  50. Dexamethasone intravitreal implant (DEX implant) is a sustained-release biodegradable implant approved for treatment of macular edema associated with retinal vein occlusion (RVO). The safety and efficacy of tr...

    Authors: Michael A Singer, Antonio Capone Jr, Pravin U Dugel, Richard F Dreyer, David G Dodwell, Daniel B Roth, Rui Shi, John G Walt, Lanita C Scott and David A Hollander
    Citation: BMC Ophthalmology 2015 15:33
    Content type: Research article Published on:
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